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      • KCI등재

        포르말린 고정 파라핀 포매된 유육종증 환자의 조직을 이용한 안지오텐신 전환 효소 유전자 다형성 검색

        김태숙,홍희연,이인철 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.4

        Background : Sarcoidosis is a systemic disease characterized by nonnecrotizing granulomas involving the lung and hilar lymph nodes. Serum angiotensin converting enzyme (sACE) levels in patients with sarcoidosis have been implicated as an indicator of granuloma burden. Recently, it has been found that ACE gene insertion/deletion (ID) polymorphism affects sACE levels in healthy individuals. Moreover, reported sACE levels were highest in the deletion/deletion (DD) genotype. Previous studies to investigate the distribution of ACE genotypes according to ethnic groups have revealed various results and have caused controversy. Methods : Polymerase chain reactions were performed to determine the ACE genotypes in fifteen formalinfixed, paraffin-embedded tissues from patients with sarcoidosis. Results : The distribution of ACE gene (I/D) polymorphism in patients with sarcoidosis was significantly different from that in normal controls. The DD genotype was more frequent in patients with sarcoidosis than in the normal controls. The D allele frequency was also higher in patients with sarcoidosis than in the normal controls. The relative risk of sarcoidosis was higher in DD homozygotes. Conclusions : These results suggested the ACE gene I/D polymorphism may play an important role in the pathogenesis and progression of sarcoidosis.

      • 靑少年의 悲觀性에 關한 硏究 : 正常兒, 孤兒 및 肢體不自由兒의 比較 硏究 A Comparative Study of normal, Orphan and Physically Handicapped Children

        金泰淑 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

        For the purpose of quantitative measuring of the pessimism of the Korean adolescent by using Beck's Hopelessness Scale, the author selected 140 normal, orphan and physically handicapped children during the period of September 1. 1978 to November 31, 1978, and analysed them statistically getting the folowing results: 1. The scores on the hopelessness-scale were significantly higher in physically handicapped and orphan groups than in the normal group. and they were significantly in the physically handicapped group than in the orphan group. (P<0.01) 2. The scores on the hopelessness factors for feeling about the future, loss of motivation and future expectations were significantly higher in the physically handicapped group than in the normal group. (P<0.01) 3. The scores on the hopelessness factors for feeling about the future(P<0.05) and loss of motivation (P<0.01) were big significantly higher in the orphan group than in the normal group and the future expectations factor was not significantly different in the orphan group and normal. 4. The scores of males and females on the Hopelessness scale and Hopelessness factors were not significantly different.

      • 임상검체에서의 Haemophilus aphrophilus 분리 5예

        김태숙,정윤섭,이삼열,설준희,양성익,이의웅 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1

        Haemophilus aphrophilus is a fastidious gram-negative bacillus found in mouth of normal individuals. Though H. aphrophilus infection is quite rate, it includes such serious ones as endocarditis and brain abscess. The authom isolated H. aphrophilus from five patients with the diagnosis of lung abscess, conjunctivitis, brain abscess and facial masticator space abscaa Two of the patients died. Three of the patients also yielded other species of bacteria from the same specimens. One of the isolate was intermediately susceptible to amikacin and resistant to tobramycin, indicating the necessity of a routine susceptibility test in order to select the proper antimicrobial agents. Since FS. Aphrophilus can be diffetentiated from other similar organisms by morphological and biochemical chamcteristics, one should determie the possibility of this organisrn when faptidious gram-negative bacilli are isolated from blood or from sites adjacent to upper respiratory tract.

      • 재가암환자 요구도 조사

        김태숙,양병국,정은경,박노례,이영숙,이영성,이석구,김영택,윤영호,허길자,Kim, Tae-Sook,Yang, Byung-Guk,Jeong, Eun-Kyeong,Park, No-Rai,Lee, Young-Sook,Lee, Young-Sung,Lee, Sok-Goo,Kim, Young-Taek,Yun, Young-Ho,Huh, Gil-Ja 한국호스피스완화의료학회 1999 한국호스피스.완화의료학회지 Vol.2 No.1

        목적 : 우리나라의 주된 사망원인인 암은 최근 들어 진단기술의 발전과 치료방법의 개선으로 전점 만성화되고 있어 결과적으로 집에서 치료받고 있는 재가암환자의 수가 증가추세에 있다. 그러나 지속적이고 체계적인 암환자 관리체계의 미비로 많은 환자들이 적정한 보건의료서비스를 받지 못하고 방치되고 있는 실정이다. 본 연구는 재가암환자의 삶의 질을 높이고 가족의 부담을 줄여주기 위한 지역사회 재가암환자 관리체계를 개발하기 위한 전단계로서 재가암환자의 서비스 요구를 파악하고자 한다. 방법 : 본 연구는 재가 암환자와 환자를 주로 돌보고 있는 가족을 대상으로 그들이 겪고 있는 어려움과 보건의료 분야의 도움을 필요로 하는 요구를 직접 면접 조사를 실시하여 조사하였다(연구대상, 중앙암등록본부 등록 환자, 455명). 결과 : 1) 암환자의 가장 중요한 증상인 통증조절에 대한 만족도는 경증 환자에서는 25.5%, 중증환자의 경우에는 46.5%가 불만이라고 응답하여 만족스러운 통증조절이 안되고 있었다. 2) 재가 암환자 및 보호자에 대한 요구도 조사결과를 보면 가장 필요한 도움으로는 경제적인 도움, 통증 및 증상조절 의료에 대한 정보제공 및 상담이었다. 3) 기본간호에 대해서는 간호필요율에 대한 충족율이 대부분 $20{\sim}30%$ 대로 낮았다. 특수간호의 경우에는 요구도가 있는 재가암환자가 많지 않았으며(5% 이내), 기본간호에 비해 간호충족율이 높았으나, 여전히 50% 정도로 낮아, 충분한 서비스가 충족되고 있지 않았다. 결론 : 재가암환자들의 서비스 요구도를 분석한 결과 암환자들이 충분한 통증 및 증상조절이 이루어지지 않고 있으며, 기본 및 특수간호의 충족률이 매우 낮은 실정이다. 향후에 재가암환자의 삶의 질을 높이고 가족의 부담을 줄여주기 위한 재가암환자 관리체계를 개발이 필요하다. Purpose : Cancer, one of the major causes of death in Korea, tends to become chronic due to the rapid development of diagnostic and therapeutic methods. As a result, the number of home-based cancer patients is in the increasing trend. However, on account of the insufficiency of continuous and comprehensive cancer patient management system, a number of cancer patients are left in a defenseless state. This study was designed for need assessment of home-based cancer patient to establish the community-based health care system for the comprehensive and continuous health care service to improve the quality of life of cancer patients and reduce rare burdens of their families. Methods : Through making a survey for needs assessment toward the health care service, the 455 respondents among home-based cancer patients answered the given enquetes to analyze the management status and problems of home-based cancer patients Results : 1) Unsatisfaction rates of pain control is 25.5 percent for mild cases, 46.5 percent for severe cases. 2) According to the needs assessment of home-based cancer patients, most of the respondents want to receive economical support, alleviation for the pain and symptoms, and the information of health care and consultation. So these needs account for the main contents of the home-based cancer patient management plan. 3) In the aspect of the satisfaction rate for basic care need, most items account for $20{\sim}30%$ of satisfaction. And the proportion of need for special case is under 5%, satisfaction rate for special care need is about 50% of satisfaction. So the home-based cancer patients are not being cared sufficiently. Conclusion : According to the result of need assessment, many home-based cancer patients received inadequate pain and symptom management. And Satisfaction rate for basic and special care need is low. So development of comprehensive and continuous health care service to improve the quality of life of cancer patients and reduce care burdens of their families is very necessary.

      • SCOPUSKCI등재
      • 충청지역 산업보건 관리실태와 건강관리 보건담당자의 사기에 관한 조사연구

        김태숙,김종임 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

        This study was carried out for 63 establishments in Chung Cheong area to evaluate the industrial health manager's morale and industrial health management state by using the scoring method of Webb's model during August, 1987. The results are as the follows: 1. The mean rate of affirmative answers for the establishments is 46%. Especially the mean rate of philosophy and of organization is 62% and 63% respectively. 2. 21% of the health managers are industrial health nurses. Many of the health managers are aged between 20 to 34. 3. The level of industrial health manager's morale shows 67%. 4. There is no statistically significant interrelationship between industrial health program and health manager's morale.

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