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청목향 Aristolochiae radix에 있어 F344 랫드의 독성
김충용,김용범,양병철,이종화,정문구,양기화,장동덕,한상섭,강부현,Kim, Choong-Yong,Kim, Yong-Bum,Yang, Byung-Chul,Lee, Jong-Hwa,Chung, Moon-Koo,Yang, Ki-Hwa,Jang, Dong-Deuk,Han, Sang-Seop,Kang, Boo-Hyon 대한수의학회 2005 大韓獸醫學會誌 Vol.45 No.1
13-week orally repeated dose toxicity was investigated to ascertain the toxic effects of Aristolochiae radix in F344 rats at dose levels of 0, 1 (0.003 AA, aristolochic acid, mg/kg), 5 (0.014 AA mg/kg), 25 (0.068 AA mg/kg), 125 (0.34 AA mg/kg), and 500mg/kg (AA 1.36 mg/kg). No mortalities were found in any of the dose groups including vehicle control groups of both sexes during the study period. Hematologic and serum biochemical examinations revealed no changes related to the test item in any of the dose groups of both sexes. However, gross findings at necropsy implicated thickening of the stomach wall. In histopathological examinations, prominent findings related to the test item treatment were observed in the stomach and urinary bladder. There were squamous cell papilloma, squamous cell hyperplasia, ulceration and erosion observed in the non-glandular stomach. Squamouse cell hyperplasia was observed at dose levels of more than 125 mg/kg in both sexes and squamous cell papilloma was observed at dose level of 500 mg/kg in both sexes. The incidence and severity of these proliferating lesions including squamous cell hyperplasia and squamous cell papilloma increased with dose dependency. Transitional cell hyperplasia was also observed in the urinary bladder at dose levels of more than 25 mg/kg in both sexes and the incidence and severity of the lesion increased with dose dependency. In conclusion, the toxic changes related to the test item treatment were observed in the stomach and urinary bladder, and the no-observed-adverse-effect level (NOAEL) was estimated to be 5 mg/kg/day for both males and females in F344 rats.
Cynomolgus Monkey에 있어 혈액학 및 혈액생화학적 지표
김충용(Choong-Yong Kim),이현숙(Hyun-Sook Lee),한수철(Su-Cheol Han),허정두(Jeong-Doo Heo),하창수(Chang-Su Ha),권명상(Myung-Sang Kwon),정문구(Moon-Koo Chung) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
To provide basic information on blood for safety assessment, physiological levels of hematology and serum chemistry were ascertained in nineteen male (average body weight, 2.86 ㎏) and sixteen female (average body weight, 2.73 ㎏) cynomolgus monkeys. Hematologic parameters included fourteen items including red blood cells (RBC) hemoglobin (Hb), hematocrit (HCT), white blood cells (WBC) and differential leukocyte counts (%WBC). Serum biochemical parameters included twenty items including alkaline phosphatase (ALP), creatinine (CREA), creatine phosphokinase (CPK), triglyceride (TG), inorganic phosphorous (IP), etc. Hematological levels showed great variation in platelet, reticulocyte and WBC, whereas showed less variation in RBC, Hb, and HCT. Serum biochemical levels showed great variation in aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, Blood urea nitrogen (BUN), glucose (GLU), total cholesterol (TCHO), CPK, TG, total bilirubin (TBIL), phospholipid (PL) and inorganic phosphate (IP), whereas showed less variation in albumin/globulin ratio (A/G ratio), total protein (TP), albumin (ALB), sodium (Na), potassium (K), chloride (Cl). Hematological determined showed greater values of Hb, and HCT in males than in females, while serum biochemical assay showed greater values of ALP, CPK and IP in males than in females. The present study will be valuable in the proper interpretation and validation of general toxicology studies using cynomolgus monkeys.
임신 중 환경오염물질 2-Bromopropane에 노출된 마우스의 모독성 평가
허정두(Jeong-Doo Heo),김충용(Chung-Yong Kim),강성철(Chen-Zhe Ziang),서정은(Jeong-Eun Suh),정문구(Moon-Koo Chung),김무강(Moo-Kang Kim),신동호(Dong-Ho Shin),김종춘(Jong-Choon Kim) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for chlorofluorocarbones (CFCs). The present study was carried out to investigate the potential adverse effects of 2-BP on pregnant dams after maternal exposure during the gestational days (GD) 6 through 17 in ICR mice. The test chemical was administered subcutaneously to pregnant mice at dose levels of 0, 500, 1000, and 1500 ㎎/㎏/day. All pregnant females were subjected to autopsy on GD 18. Treatment-related clinical signs, as evidenced by dose-dependent increases in the incidence and severity of rough fur, swelling, induration, crust formation, and ulceration at the injection sites, were observed at dose levels of above 1000 ㎎/㎏/day. Maternal body weight on GD 18 and maternal body weight gain for the intervals GD 6-17 (treatment period) were suppressed at a dose level of 1500 ㎎/㎏ in a dose-dependent manner, but not statistically significant. Hematological investigations revealed a dose-dependent decrease in the number of platelet at a dose level of 1500 ㎎/㎏. Fetal body weights of both sexes in the 1500 ㎎/㎏ group were also decreased in a dose-dependent manner. There were no adverse effects on mortality, food consumption, organ weights, and reproductive findings except for decreased fetal body weight in any treatment group. Based on these results, it was concluded that the 12-day repeated subcutaneous dose of 2-BP resulted in an increased incidence of clinical signs, suppressed maternal body weight, reduced platelet count and decreased fetal body weight at a dose level of 1500 ㎎/㎏/day in pregnant mice. In the present experimental conditions, the no-observed-adverse-effect level of 2-BP was considered to be 500 ㎎/㎏ for dams.