Polyesters Syntheses via Palladium Catalyzed Carbonylative Polycondensation Reaction

김영조 ( Young Cho Kim ),유동성 ( Dong Seong Ryu ),김진일 ( Jin Il Kim ) 한국공업화학회 1991 한국공업화학회 연구논문 초록집 Vol.1991 No.0

Novel Polyesters were succesfully synthesized by palladium catalyzed carbonylative polycondensation of xylene dibromides and various diols with carbon monoxide. The effects of reaction variables, such as catalysts, bases, solvents, carbon monoxide pressure, and reaction temperature, were discussed in detail for the reaction of p-dibromoxylene and 2, 2-bis(4-hydroxyphenyl)propane with carbon monoxide. The polyesters were characterized by IR, elemental analysis, GPC, DSC, TGA, and polarizing microscope.

위장관 ; 헬리코박터 파일로리에 감염된 위 상피세포에서 DNA 이중나선절단 관찰

장영준 ( Young Jun Chang ),변상원 ( Sang Won Byun ),김형근 ( Hyung Keun Kim ),조영석 ( Young Seok Cho ),김성수 ( Sung Soo Kim ),김진일 ( Jin Il Kim ),김재광 ( Jae Kwang Kim ),정은선 ( Eun Sun Jung ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2

Background/Aims: DNA double strand breaks (DSB) is one of the critical types of DNA damage. If unrepaired, DSB is accumulated in the nucleus of cells, the cells become apoptotic or transform to tumor by way of genomic instability. Some of malignant cancers and its premalignant lesions were proven to have DSB in their nuclei. There was no report that Helicobacter pylori (H. pylori), the gastric carcinogen, induce DNA DSB in gastric epithelium in vivo. The aim of this study was to investigate whether H. pylori induce DSB in the gastric epithelial cells of chronic gastritis. Methods: Immunohistochemical stains were performed for the DSB markers, phospho-53BP1 and γH2AX, in the gastric epithelium derived from 44 peptic ulcer disease patients before and after H. pylori eradication. DNA fragmentation assay was performed in the cell line to investigate the DNA damage by H. pylori infection. Results: The mean expression score of γH2AX was significantly higher in the H. pylori infected gastric epithelium as compared to the H. pylori eradicated gastric epithelium (8.8±5.5 vs. 6.2±5.3 respectively; p=0.008). The expression score of phospho-53BP1 between before and after eradication of H. pylori was not statistically different, but tended to be higher in H. pylori infection. DNA fragmentation was developed significantly more in the cell lines after infection with H. pylori. Conclusions: DSB of DNA damage was typical feature of H. pylori infection in the gastric epithelium. (Korean J Gastroenterol 2012;60:79-85)

우리나라 농촌지역사회 주민의 위장관 증상의 유병률

추교영(Kyo Young Choo),최명규(Myung Gyu Choi),최황(Hwang Choi),이동수(Dong Soo Lee),김진일(Jin Il Kim),김성수(Sung Soo Kim),방춘상(Choon Sang Bhang),박수헌(Soo Heon Park),김재광(Jae Kwang Kim),한석원(Sok Won Han),최규용(Kyu Yong Cho 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.1

N/A Background/Aims: Chronic gastrointestinal (GI) symptoms are believed to be common in the general population, but there is a lack of data from Korea. The aim of this study was to es1imate the prevalence of chronic gastrointestinal symptoms in a rural community in Korea by using the Bowel Symptom Questionnaire (BSQ), which was based on the multinational diagnotic Rome criteria for functional bowel disorders, as a measure of GI symptoms. Methods: A cross-sectional survey, using a reliable and valid questionnaire based on the fulfillment of the Rome criteria, was performed in a densely populated district in a Korean rural community on the residents aged l8-69 yr (mean 48±14 yr). 95,5% responded (n=420). All respondents were interviewed at their home or offices by a team of interviewers. Results: Two thirds of Korean rural residents experience gastrointestinal symptoms and one fifth of them visit a clinic or hospital at least once a year. Prevalences of weekly heartburn, gastroesophageal reflux disease, dyspepsia, irritable bowel syndrome (IBS), and chronic constipation were 5.2% (95% confidence interval [CI], 3.l-7.4, 2.6% (95% Cl, 1.1-4.2), 15.5% (95% CI, 11.9-19.0), 8.6% (95% CI, 3.8-11,3), and 24.3% (95% CI, 20.1-28.5) respectively. The prevalence of dyspepsia was 25%, taking medication usage into consideration. Ulcer-like dyspepsia (11.2%) was the most common subtype and 40% of the subjects with dyspepsia were classified into more than one subtype of dyspesia. There was an overlap between subjects with IBS and dypepsia with 6.1% of dypeptics having IBS and ll,l% of IBS patients having dypepsia. Conclusions: The prevalence of GERD was low in Korea compared with that of the Western countries. The prevalences of dyspepsia and IBS were similar to those of the Western countries. The most common gastrointestinal symptom in a rural community in Korea is dyspepsia, (Korean Journal of Castrointestinal Motility 2000;6:31-43)

Polyesters Syntheses via Palladium Catalyzed Carbonylative Polycondensation Reaction

김영조,유동성,김진일 ( Young Cho Kim,Dong Seong Ryu,Jin Il Kim ) 한국공업화학회 1991 한국공업화학회 연구논문 초록집 Vol.1990 No.3

인터페론 용량에 따른 만성 B형 간염 치료에 대한 유효성 평가

김태호 ( Tae Ho Kim ),김창환 ( Chang Whan Kim ),조근종 ( Keun Jong Cho ),한석원 ( Sok Won Han ),정대영 ( Dae Young Cheong ),김진일 ( Jin Il Kim ),최규용 ( Kyu Yong Choi ) 대한내과학회 2007 대한내과학회지 Vol.73 No.5

Background: Infection with hepatitis B virus has been a major health problem. Chronic viral hepatitis B is the principal cause of chronic liver disease, cirrhosis, and hepatoma. A number of studies have showed that a course of interferon (INF) treatment induces a long-term remission in 20~40% of patients. Compared with the use of lamivudine, INF therapy is followed by delayed clearance of HBsAg and the treatment improves the natural history of chronic hepatitis B. The aim of this study is to evaluate the efficacy of the use of different dosages of alpha-interferon treatment in patients with chronic hepatitis B. Methods: We conducted a one-and-a-half year, randomized clinical trial of interferon in 24 Korean chronic hepatitis B patients with a positive HBeAg, and excluded other liver problems with biopsies. The patients were randomly assigned to receive 5 million units (n=10) of interferon-α2b and 10 million units (n=14) of interferon-α2b three times weekly for 16/24 weeks. Patients were followed for 12 months after the cessation of the therapy, and the patients received a second biopsy. Results: After treatment with interferon, 29.2% of the patients became negative for HBeAg and the presence of HBV DNA. Fifty percent of the patients showed histological improvement. The differences of the loss of HBeAg, HBV DNA and histological improvement between the two groups were not significant. HBV DNA and ALT were not valuable as predictive variables in treatment efficacy. However, the rate of histological improvement in patients with a low ALT level was higher. Conclusions: The administration of different doses of interferon-α2b during treatment in patients with chronic hepatitis B did not show a significant difference in efficacy.(Korean J Med 73:464-473, 2007)

내시경 검사 후 다음 내시경 검사의 수검 의지에 영향을 미치는 요인

오경주 ( Kyeong Joo Oh ),김진일 ( Jin Il Kim ),정대영 ( Dae Young Cheung ),조세현 ( Se Hyun Cho ),박수헌 ( Soo Heon Park ),한준열 ( Joon Yeol Han ),김재광 ( Jae Kwang Kim ),최규용 ( Kyu Yong Choi ) 대한내과학회 2007 대한내과학회지 Vol.73 No.5

Background: The purpose of this study was to evaluate the association of physical distress and mental health characteristics with the willingness to repeat an esophagogastroduodenoscopic (EGD) examination. Methods: A questionnaire survey was conducted on 137 patients who had an EGD procedure. The mental health status was evaluated with the Checklist-90-Revision tool, which is based on the Multidimensional Self Report Symptom Inventory. Results: The results were as follows. 1) The elderly and those patients with two or more procedures had a significantly higher willingness to repeat the EGD examination. Those who were willing to repeat the examination had more EGD examinations than those who did not (p<0.05). 2) As for the mental health characteristics, persons with a willingness to repeat the EGD examination showed significantly lower scores on the interpersonal, sensitivity, depression, anxiety, hostility, and paranoid ideation than did those without a willingness. 3) As for the degree of physical distress during the EGD examination, persons with a willingness to repeat the EGD examination had significantly lower scores on the total symptom score and global discomfort score than those without a willingness (p<0.05). 4) The younger patients, under 30, had a significantly lower willingness to repeat the EGD examination than did the elderly patients over 60 (OR=86.03, 95% CI 2.11-999). According to patient occupations, homemakers showed a significantly higher willingness than did others (OR=16.24, 95% CI 1.69-156.23). Conclusions: The results of this study suggested that a willingness to repeat the EGD examination was closely associated with the mental health characteristics of the patients.(Korean J Med 73:481-488, 2007)

중장의 비회전과 십이지장 전치 간문맥을 포함한 다발성 복강내 기형

박용범 ( Yong Bum Park ),김진일 ( Jin Il Kim ),정대영 ( Dae Young Cheung ),조세현 ( Se Hyun Cho ),박수헌 ( Soo Heon Park ),한준열 ( Joon Yeol Han ),김재광 ( Jae Kwang Kim ) 대한내과학회 2007 대한내과학회지 Vol.73 No.5

Nonrotation of the intestine is a rare disorder mostly found in childhood. During adult life, nonrotation of the intestine is found either during surgery or during the evaluation of unrelated symptoms. A preduodenal portal vein is also a rare anomaly. These anomalies are associated with situs inversus, and duodenal, pancreatic, biliary and cardiovascular anomalies. A 21-year-old man presented with mild constipation. During the evaluation, we found multiple intraabdominal anomalies, including nonrotation of the intestine, a preduodenal portal vein, polysplenia, and an annular and short pancreas.(Korean J Med 73:548-551, 2007)

위장관 유암종의 내시경적 치료 성적에 대한 고찰

박용범 ( Yong Bum Park ),김진일 ( Jin Il Kim ),하병화 ( Byung Hwa Ha ),정대영 ( Dae Young Cheung ),김태호 ( Tae Ho Kim ),김창환 ( Chang Hwan Kim ),김성수 ( Sung Soo Kim ),조세현 ( Se Hyun Cho ),박수헌 ( Soo Heon Park ),채현석 ( Hi 대한내과학회 2007 대한내과학회지 Vol.73 No.3

Background: The treatment of choice of gastrointestinal carcinoid tumors has been thought to be radical excision. However, surgical treatment has been substituted by endoscopic treatment in cases of small gastrointestinal carcinoid tumors. We evaluated the effectiveness of endoscopic treatment for gastrointestinal carcinoid tumors. Methods: We reviewed the medical records and endoscopic findings of 50 cases of gastrointestinal carcinoid tumors diagnosed in St. Mary`s Hospital, Holy Family Hospital, and Uijeongbu St. Mary`s Hospital, all affiliated organizations of the Catholic University Medical Center of Korea, from January 2001 to December 2006. Results: The mean age of the patients was 52.6±13.6 years-old. The mean tumor size was 10.1±5.6 mm. Thirty-eight cases were treated by endoscopy (mean tumor size: 8.6±4.5 mm), eleven cases were treated by surgery (mean tumor size: 13.5±6.1 mm), and one case with multiple metastases was untreatable by either endoscopy or surgery. Twenty five cases of endoscopic therapy were treated by endoscopic mucosal resection or endoscopic submucosal dissection. Thirteen cases were resected by use of a conventional polypectomy. Two cases of the conventional polypectomy were resected incompletely, and were treated with an additional endoscopy. No cases of endoscopic treatment have recurred during the follow-up period. Conclusions: Recently, the incidence of carcinoid tumors is on the increase in the gastrointestinal tract, as determined by performing frequent endoscopic examinations in Korea. If the gastrointestinal carcinoid tumor is limited to the submucosal layer, endoscopic treatment could be sufficient as the primary treatment in selected patients with a tumor diameter of 10 mm or less in the duodenum and 15 mm or less in the stomach and rectum.(Korean J Med 73:274-282, 2007)

복벽에 발생한 방선균증

김경훈 ( Kyung Hoon Kim ),이진수 ( Jin Soo Lee ),조형준 ( Hyeong Jun Cho ),최승봉 ( Seung Bong Choi ),정대영 ( Dae Young Cheung ),김진일 ( Jin Il Kim ),이인규 ( In Kyu Lee ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.4

Actinomycosis is a chronic suppurative granulomatous infectious disease caused by actinomyces species that is characterized by formation of characteristic clumps called as sulfur granules. Abdominal actinomycosis is a rare disease and is often difficult to diagnose before operation. Abdominal actinomycosis infiltrating into the abdominal wall and adhering to the colon is even rarer. Most abdominal actinomycosis develops after operation, trauma or inflammatory bowel disease, and is also considered as an opportunistic infection in immunocompromised patient with underlying malignancy, diabetes mellitus, human immunodefidiency virus infection, etc. Actinomycosis is diagnosed based on histologic demonstration of sulfur granules in surgically resected specimen or pus, and treatment consists of long-term penicillin based antibiotics therapy with or without surgical resection. Herein, we report an unusual case of abdominal wall actinomycosis which developed in a patient after acupuncture and presented as abdominal wall mass that was first mistaken for abdominal wall invasion of diverticulum perforation. (Korean J Gastroenterol 2015;65:236-240)

상부위장관 점막근층 혹은 고유근층에서 기원한 중간엽종양의 내시경 특징에 대한 비교 연구

송준호 ( Jun Ho Song ),김진일 ( Jin Il Kim ),김현진 ( Hyun Jin Kim ),조형준 ( Hyung Jun Cho ),김혜강 ( Hye Kang Kim ),정대영 ( Dae Young Cheung ),박수헌 ( Soo Hern Park ),김재광 ( Jae Kwang Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.2

목적: 상피하종양은 대부분 무증상으로 내시경검사에서 우연히 발견된다. 이번 연구는 점막근층 기원의 상피하종양과 고유근층 기원의 상피하종양에서 상부위장관 내시경검사와 내시경초음파검사로 관찰되는 특징을 분석하였다. 대상 및 방법: 2006년 3월부터 2012년 2월까지 가톨릭대학교 여의도성모병원에서 상부위장관 내시경검사에서 상피하종양이 의심되어 내시경초음파검사를 받은 환자 중, 점막근층 혹은 고유근층에 병변이 있는 총 286명의 환자에서 총 307개의 병변을 후향적으로 조사하였다. 결과: 점막근층 기원의 상피하종양 크기는 10.5±6.9 mm로 고유근층 기원의 상피하종양 크기(14.3±13.9 mm)보다 작았다(p=0.035). 점막근층 기원의 상피하종양은 식도에서 69.1%로 많았으며, 고유근층 기원의 상피하종양은 위의 체부에 43.3%로 많았다(p<0.001). 점막근층 기원의 상피하종양이 조직 겸자에 의한 움직임이 있는 경우가 80.4%로 많았고 (p=0.001), 고유근층 기원의 상피하종양이 조직겸자에 의하여 눌러지지 않는 경우가 72.4%로 많았다(p<0.001). 내부에 코는 점막근층 기원의 상피하종양의 89.7%에서, 고유근층 기원의 상피하종양의 81.9%에서 균질하게 관찰되었다. 결론: 식도에서는 점막근층 기원의 상피하종양이 많이 발견되고 위에서는 고유근층 기원의 상피하종양이 많이 발견되었다. 점막근층 기원의 상피하종양은 크기가 작고, 움직임이 많으며, 단단하여 눌러지지 않았다. 내시경초음파검사에서 점막근층과 고유근층 기원의 상피하종양에서 내부 에코 차이는 없었다. Background/Aims: Subepithelial tumors are occasionally found during upper gastrointestinal endoscopy. The purpose of this study was to evaluate endoscopic characteristics of mesenchymal tumors originating from muscularis mucosa or muscularis propria. Methods: A total of 307 mesenchymal tumors of the upper gastrointestinal tract were diagnosed between March 2006 and February 2012 at Yeouido St. Mary`s Hospital (Seoul, Korea). Data on endoscopic and endoscopic ultrasonographic findings were collected and analyzed by retrospectively reviewing the medical records. Results: The mean size of the mesenchymal tumors originating from muscularis mucosa was significantly smaller than those originating from muscularis propria (10.5±6.9 mm vs. 14.3±13.9 mm, p=0.035). The most common locations of the mesenchymal tumors originating from muscularis mucosa and muscularis propria were esophagus (69.1%) and body of the stomach (43.3%), respectively (p<0.001). Rolling sign was more commonly observed with mesenchymal tumors originating from muscularis mucosa (80.4%, p=0.001), and cushion sign was more frequently absent with those originating from muscularis propria (72.4%, p<0.001). Internal echo was homogenous in 89.7% and 81.9% of mesenchymal tumors originating from muscularis mucosa and muscularis propria, respectively (p=0.092). Conclusions: The size, location, and movability of mesenchymal tumors originating from muscularis mucosa were different from those of mesenchymal tumor originating from muscularis propria.propria. (Korean J Gastroenterol 2013; 62:92-96)