복수 동반 간병변 환자의 평위산(平胃散) 합(合) 위령탕가미방 투여 호전 1례

김진원,정병주,우성호,심효주,나유진,김용호,서호석,이원희,김병철,Kim, Jin-Won,Jeong, Byeong-Ju,Woo, Sung-Ho,Shim, Hyo-Ju,Na, Eu-Jin,Kim, Yong-Ho,Seo, Ho-Seok,Lee, Won-Hui,Kim, Byung-Chul 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4

Background : Liver cirrhosis is a disease of the liver in which normal cells are replaced by scar tissue. This condition results in the failure of the liver to perform many of its usual functions. Liver cirrhosis includes ascites, jaundice, portal hypertension, varices etc. Objectives : This study was to see if there is a decrease in ascites of liver cirrhosis to under acupuncture and herbal treatment to test their validity. Methods : Measuring the response to treatment of ascites by giving pyengwie-san hap wieryungtang gamibang and treating the patient with acupuncture, these clinical symptoms were observed: weight, abdominal circumference, abdominal SONO, chest X-ray, and lab findings. Results : Over 18 days the daily average loss of weight and abdominal circumference 0.43kg and 0.56cm, respectively. Lab findings of liver functions showed improvement. Conclusions : This report shows a role for acupuncture and herbal treatment for treating ascites in liver cirrhosis.

파킨슨병으로 유발된 진전이 한약 치료를 통하여 호전된 치험 1례

김진원,김병철,우성호,나유진,심효주,이원희,이지영,서호석,김용호,정병주,Kim, Jin-Won,Kim, Byung-Chul,Woo, Sung-Ho,Na, Yu-Jin,Shim, Hyo-Ju,Lee, Won-Hui,Lee, Ji-Young,Seo, Ho-Seok,Kim, Yong-Ho,Jeong, Byeong-Ju 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4

As society ages, the seriousness of Parkinson's disease in the elderly increases. This study was performed in order to evaluate the effect of Korean medical treatments on Parkinson's symptoms. An elderly patient was diagnosed with Parkinson's disease by clinical symptoms, which were resting tremor, pill-rolling tremor and mild bradykinesia. We treated her disease with Korean medical treatment, including herbal medicine and acupuncture therapy and excluding western medication. For the herbal medicine, Insamyangyeong-tang (人參養榮湯), Bobi-tang (補脾湯), Dokhwaljihwang-tang (獨活地黃湯) and Sipimijihwang-tang (十二味地黃湯) were primarily used. In result, the clinical symptoms, measured by unified Parkinson's disease rating scale (UPDRS) and modified Hoehn and Yahr stage (H-Y stage), of Parkinson's disease in this patient had improved after the Korean medical treatment. This study suggests that Korean medical treatments can be applicable to improve symptoms in patients with Parkinson's disease.

지진 하중조건에서 배관 건전성 평가를 위한 실험적 연구 현황

김진원,김종성,김윤재,권형도,Kim, Jin Weon,Kim, Jong Sung,Kim, Yun Jae,Kweon, Hyeong Do 한국압력기기공학회 2017 한국압력기기공학회 논문집 Vol.13 No.1

This paper reviewed and summarized the experimental studies conducted during last three decades to evaluate the structural integrity and to establish the acceptance criteria for piping system of nuclear power plants (NPPs) under seismic loading condition. These experimental studies contain the results of large-scale piping system tests under excessive seismic loading as well as standard specimen tests, simplified piping specimen tests, and piping components tests under simplified dynamic and cyclic loading. These would be useful as a basis for establishing integrity assessment procedure and acceptance criteria for piping systems of NPPs under beyond design basis earthquake (BDBE) conditions, and also could be used in planing the scope and direction of further related researches.

전환장애를 간양화풍(肝陽化風)으로 변증(辨證)한 치험 1례(例)

김진원,정병주,우성호,김병철,손지형,임호제,황규동,서호석,김용호,한승혜,Kim, Jin-Won,Jeong, Byeong-Ju,Woo, Sung-Ho,Kim, Byung-Chul,Son, Ji-Hyung,Lim, Ho-Jae,Hwang, Gyu-Dong,Seo, Ho-Seok,Kim, Yong-Ho,Han, Seung-Hea 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2

Conversion disorder lacks temperamental grounds and is a type of somatoform disorder that includes alteration or loss of physical functions implicated in physical deficit suggestive psychological conflict. There is high incidence of return of conversion disorder and difficulty in producing exact approaches of cure and apparent effects of remedy with symptomatic treatment alone because of its complex clinical symptoms. The approach of Oriental Medicine in treatment of conversion disorder is to apprehend relative symptoms from the syndrome combined with several annexational symptoms centering around sequential symptoms. Thereupon, author made a Ganyanghwapung comprehensive diagnosis was conducted using Oriental Medicine measures by differential diagnostic methods in psychosomatic patients whose cases are diagnosed as conversion disorder. Then, Cheonmagudeungeum Gagambang was prescribed for them and it brought on satisfactory effects from the first or second treatment. There have been many cases reporting the application of Oriental Medicine treatment to conversion disorder to date and outcomes have also been favorable. Results of this study likewise suggest that this Oriental Medicine treatment for conversion disorder is effective.

기술초대석 III - HSA800 강재를 적용한 보-기둥 중간모멘트 접합부 논스캘럽 공법 소개

김진원,이승은,김도환,김진호,Kim, Jin-Won,Lee, Seung-Eun,Kim, Do-Hwan,Kim, Jin-Ho 한국건축구조기술사회 2014 건축구조 Vol.21 No.6

Complete genome sequence of Pantoea intestinalis SRCM103226, a microbial C40 carotenoid zeaxanthin producer

김진원,하광수,정성엽,정도연,Kim, Jin Won,Ha, Gwangsu,Jeong, Seong-Yeop,Jeong, Do-Youn The Microbiological Society of Korea 2019 미생물학회지 Vol.55 No.2

Pantoea intestinalis SRCM103226은 식용곤충 밀웜으로부터 분리하였으며, zeaxanthin을 메인으로 생산하였다. P. intestinalis SRCM103226의 유전체 분석을 실시하여 4,784,919 bp 크기의 염기서열, GC 비율은 53.41%로 나타났으며, 플라스미드는 존재하지 않는다. RAST server를 이용하여 annotation한 결과 4,332개의 코딩유전자, 22개의 rRNA, 85개의 tRNA 유전자가 확인되었다 지놈분석결과 zeaxanthin 생합성회로 5개 유전자를 가지고 있다. 이러한 유전체 정보는 zeaxanthin 생합성 경로의 분자 진화의 비교 유전체학 연구에 대한 기초 정보를 제공한다. Pantoea intestinalis SRCM103226, isolated from edible insect mealworm overproduces zeaxanthin as a main carotenoid. The complete genome of P. intestinalis SRCM103226 was sequenced using the Pacific Biosciences (PacBio) RS II platform. The genome of P. intestinalis SRCM103226 comprises a 4,784,919 bp circular chromosome (53.41% G+C content), and is devoid of any extrachromosomal plasmids. Annotation using the RAST server reveals 4,332 coding sequences and 107 RNAs (22 rRNA genes, 85 tRNA genes). Genome annotation analysis revealed that it has five genes involved in the carotenoid pathway. The genome information provides fundamental knowledge for comparative genomics studies of the zeaxanthin pathway.

원주방향 관통균열 배관의 균열열림 평가에 미치는 압력유기굽힘의 구속효과

김진원,박치용,Kim, Jin-Won,Park, Chi-Yong 대한기계학회 2001 大韓機械學會論文集A Vol.25 No.11

The effects of restraint of pressure induced bending(PIB) on crack opening for circumferential through-wall crack in a pipe were investigated. In this study, the elastic and elastic-plastic finite element analyses were performed to evaluate crack opening displacement(COD) for various restraint conditions and crack size. The results showed the restraint of PIB decreased crack opening for a given crack size and tensile stress, and the decrease in crack opening was considerable for large crack and short restraint length. A1so, the effect was more significant in tole results of elastic-plastic analysis compared with in the elastic analysis results. In the elastic-plastic analysis results, tole restraint effect was increased with increasing applied tensile stress corresponding to internal pressure. Additionally, the restraint effect on COD was independent on the variation in pipe diameter and decreased with increasing pipe thickness, and It depended on not total restraint length but shorter restraint length for non-symmetrically restrained.

농경지 내 생태계교란식물의 분포

김진원,이인용,이정란,Kim, Jin-Won,Lee, In-Yong,Lee, Jeongran 한국잡초학회 한국잔디학회 2017 Weed & Turfgrass Science Vol.6 No.2

Invasive alien species (IAS) can affect agricultural ecosystem negatively and critically. The geographical distributions of nine IAS plants in Korean orchards and uplands were investigated. Ambrosia artemisiifolia distributed widely in Korean peninsula and Ambrosia trifida distributed intensively in Gyeonggi-do. Aster pilosus distributed in Gyeonggi-Gangwon region and Lactuca scariola distributed linear region from the north-western to south-eastern part of Korea. Hypochaeris radicata distributed mainly in Jeju-do and Solanum carolinense distributed in eastern Gyeonggi-do. Rumex acetosella and Sicyos angulatus sporadically occurred in Korean croplands and Eupatorium rugosum was found in one region only. The distribution of IAS plants in croplands was very similar to that in non-croplands suggesting that ecological position of arable lands is not different from that of non-arable lands. Therefore, IAS plants in the croplands should be managed for not only prevention of yield reduction, but also protection or maintenance of original ecosystem. Development of management methods apposite to current Korean status are required to control IAS plants in croplands. 본 연구에서 국내의 농경지 내 생태계교란식물의 분포를 알아보고자 한다. 생태계교란식물 9종의 지역적 분포를 알아보기 위해 분포지도를 작성하였다. 단풍잎돼지풀과 돼지풀은 전국적인 분포를 보였으나 단풍잎돼지풀은 경기북부에 집중적으로 발생하고 있었고, 돼지풀은 경우에는 강원 및 전라 지역을 제외한 전국에 고르게 분포하고 있었다. 미국쑥부쟁이는 경기도 및 강원도 지역에 집중적으로 분포하고 있었으며, 가시상추의 경우 서북-동남 방향으로 분포하고 있었다. 서양금혼초는 제주도에 집중적으로 발생하고 있었고, 도깨비가지는 주로 경기 동부 지역에 분포하고 있었다. 애기수영과 가시박의 경우 전국에 산발적으로 발생하고 있었으나 경기도 지역에 상대적으로 많은 비율로 발생하고 있었으며, 서양등골나물은 경기도 연천군의 과수원 및 밭작물 재배지에만 발생하는 것으로 나타났다. 농경지 내 생태계교란식물의 분포는 비농경지와 거의 같은 경향을 보였으며, 이는 농경지의 생태적 지위가 비농경지와 다르지 않음을 의미한다. 따라서 작물의 수량 및 품질을 떨어뜨리기 때문에 잡초를 관리해야한다는 인식에서 더 나아가 주변 생태계에 부정적인 영향을 줄 수 있기 때문에 제거해야 한다는 인식의 전환이 필요하다. 또한, 각 생태계 교란식물의 효율적인 방제를 위해 제초제 약효/약해 연구나 발아생리 연구와 같은 다양한 연구가 필요한 실정이다.

내압과 굽힘하중하에서 감육배관의 국부허용두께 평가

김진원,박치용,김범년,Kim, Jin-Won,Park, Chi-Yong,Kim, Beom-Nyeon 대한기계학회 2001 大韓機械學會論文集A Vol.25 No.1

This study proposed an analytical method to evaluate a local allowable wall thickness (LAWT) for locally thinned pipe subjected to internal pressure and bending moment. In this method, the stresses in the thinned region were calculated by finite element analysis and plastic collapse was applied as a failure criterion of thinned pipe. Using this method, LAWT for a simplified thinned pipe was evaluated with variation in axial extent of thinned area, and it was compared with allowable wall thickness provided by previous pipe wall thickness criteria. The results showed that the LAWT was lower, about 50%, than that calculated by construction code or ASME Code N-597, and it was higher, about 2 times, than that estimated by evaluation model based on pipe experiments. In addition, LAWT was decreased with increasing axial extent of thinned area and saturated with further increase in axial extent. And, the variation in LAWT with axial extent of thinned area depended on type of load, especially a magnitude of bending moment, considering in the evaluation.

Isolation and identification of monkeypox virus MPXV-ROK-P1-2022 from the first case in the Republic of Korea

김진원,이민지,Shin Hwachul,최치환,Choi Myung-min,Jee Woong Kim,Hwajung Yi,유천권,이기은 질병관리본부 2022 Osong Public Health and Research Persptectives Vol.13 No.4

Objectives: Monkeypox outbreaks in nonendemic countries have been reported since early May 2022. The first case of monkeypox in the Republic of Korea was confirmed in a patient who traveled to Europe in June 2022, and an attempt was made to isolate and identify the monkeypox virus (MPXV) from the patient’s specimens.Methods: Clinical specimens from the patient were inoculated in Vero E6 cells. The isolated virus was identified as MPXV by the observation of cytopathic effects on Vero E6 cells, transmission electron microscopy, conventional polymerase chain reaction(PCR), and sequencing of PCR products.Results: Cytopathic effects were observed in Vero E6 cells that were inoculated with skin lesion swab eluates. After multiple passages from the primary culture, orthopoxvirus morphology was observed using transmission electron microscopy. In addition, both MPXV-specific (F3L and ATI) and orthopoxvirus-specific genes (A39R, B2R, and HA) were confirmed by conventional PCR and Sanger sequencing.Conclusion: These results indicate the successful isolation and identification of MPXV from the first patient in the Republic of Korea. The isolated virus was named MPXV-ROK-P1-2022.