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자궁근종환자에서 자궁적출술 전후 혈청 인슐린유사 성장인자 결합단백-3 분해효소의 동향에 관한 연구
김정구 ( Jung Gu Kim ),구승엽 ( Seung Yup Ku ),김석현 ( Seok Hyun Kim ),서창석 ( Chang Suk Suh ),지병철 ( Byung Chul Jee ),문신용 ( Shin Yong Moon ),최영민 ( Young Min Choi ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
Objective : To investigate change in the activity of insulin-like growth factor binding protein-3 (IGFBP-3) protease and change in serum IGFBP-3 levels measurable by western ligand blot and immunoradiometric assay after hysterectomy, in patients with uter
한국폐경여성에서 Interleukin (IL)-6 유전자 G(-634)C 다형성과 전혈세포에 의한 IL-6 생산 및 골밀도의 연관성에 관한 연구
김정구 ( Jung Gu Kim ),임경실 ( Kyung Sil Lim ),구승엽 ( Seung Yup Ku ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ) 대한폐경학회 2003 대한폐경학회지 Vol.9 No.4
목적: 한국 폐경여성에서 IL-6 유전자 G(-634)C 다형성양상과 전혈세포에서 IL-6 생산 및 골밀도사이에 연관성이 있는가를 알아보고자 하였다. 연구 방법: 자연폐경여성 196명을 대상으로 하여 IL-6 유전자 G(-634)C 다형성양상을 BsrBI RFLP 분석하였고 요추 및 대퇴 근위부에서의 골밀도를 DEXA로, 혈청 OST, CTX,를 면역측정법으로 측정하였다. 또한 2일간 LPS 첨가 또는 비첨가하여 배양된 전혈세포에서의 배양액내 IL-6를 효소면역법으로 각각 측정하였다. 결과: IL-6 유전자 G(-634)C 다형성에 의한 GG, CG, CC 유전자형의 CTX, OST 농도 차이가 없었다. LPS 자극 여부에 관계없이 유전자형에 따른 전혈세포에서 IL-6 생산은 차이가 없었다 정상골밀도를 가진 여성, 골감소증 여성, 골다공증여성에서 IL-6 유전자형의 분포양상의 차이가 없었고 LS에 의한 자극여부에 관계없이 골밀도상태에 따른 전혈세포엣의 IL-6 생산은 차이가 없었다. 전혈세포에서의 IL-6 생산은 요추와 대퇴근위부에서의 골밀도 및 혈청 OST, CTX 농도사이에 상관계가 없었다. 결론: 한국여성에서 IL-6 유전자 G(-634)C 다형성은 골밀도 및 전혈세포에서의 IL-6생산에 영향을 미치지 않는다. Objective: To investigate the G(-634)C polymorphism in interleukin(OL)-6 gene in postmenopausal Korean women and to evaluate relationship between this polymorphism, bone mineral density (BMD), the production of IL-6 from whole blood cells. Methods: The G(-634)C polymorphism in the IL-6 gene was examined by BsrBI restriction fragment length polymorphism(RFLP) in 196 postmenopausal Korean women, whole blood cells were cultured with or without lipopolysaceharide(LPS) for 2 days and IL-6 produced by these cells were measured using enzyme-linked immunosorbent assay. Serum osteocalcin, and CrossLaps(CTX) were measured by immunoassay, and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry. Results: The distributions of IL-6 BsrBI polymorphism were as follows; GG 6.6%, CG 40.3%, CC 53.1%. No differences in BMD of the lumbar spine and proximal femur, serum OST and CTX levels across the IL-6 production from whole blood cells among normal, osteopenic, and osteoporotic postmenopausal women, Regardless of LPS stimulation, the IL-6 production from whole blood cells did not correlate with BMD of the lumbar spine and proximal femur or serum levels of bone turnover markers Conclusion: The IL-6 G(-634)C polymorphism is not associated with BMD or IL-6 production from whole blood cells in Korean women,
김정구 ( Jung Gu Kim ),구승엽 ( Seung Yup Ku ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.6
Objective: To investigate the relationship of polymorphisms in osteoprotegerin (OPG)-receptor activator of NF-kB ligand (RANKL) gene to changes in circulating OPG and soluble RANKL (sRANKL) levels and in bone mineral density (BMD) after hormone therapy (HT) in postmenopausal Korean women. Methods: The OPG T245G, and G1181C polymorphisms and RANKL rs2277438 A/G polymorphism were analyzed by polymerase chain reaction-restriction fragment length polymorphsim (PCR-RFLP) or direct DNA sequencing in 236 postmenopausal Korean women receiving sequential HT for 1 year. Serum OPG, sRANKL, bone alkaline phosphatase, CrossLaps (CTX), osteocalcin, clacitonin, parathyroid hormone, calicum, and phophorus were measured using enzyme-linked immunosorbent assay (ELISA), immunoassay and atomic absorptiometry respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. Results: The annual percent changes of BMD were not associated with single or combined genotypes of OPG and RANKL gene polymorphisms, and the distributions of these genotypes were not different between HT-responders and HT-nonresponders (women who lose more than 3% of bone mass per year). After HT of 6 months, change in serum sRANKL levels was significantly higher in GG genotype than in other genotype of RANKL gene polymorphism. No differences in the 6 month changes of other bone turnover markers including circulating OPG levels after HT were noted across single OPG genotype and combined genotypes of OPG and RANKL polymorphisms. Conclusions: The OPG T245G, and G1181C polymorphisms, and RANKL polymorphism did not associate with change in BMD after HT in postmenopausal Korean women, and RANKL polymorphism affects change in circulating sRANKL levels after HT.
한국 자연폐경여성에서 기질 Gla 단백의 유전자 다형성과 혈청 osteocalcin 농도 및 골밀도와의 연관성
김정구 ( Jung Gu Kim ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Seok Suh ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6
Objective: To investigate the relationship between the matrix Gla protein (MGP) gene polymorphism, serum osteocalcin levels and bone mineral density (BMD) in postmenopausal Korean women. Methods: The MGP gene cytosine-adenine (CA) polymorphism was analyzed by polyacrylamide-urea gel eletrophoresis, genescan and DNA sequencing in 267 postmenopausal Korean women. Serum osteocalcin, bone alkaline phosphatase (BAP), and CrossLaps (CTX) were measured by immunoassay, and enzyme linked immunosorbent assay respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. Results: Six MGP alleles were observed with product sizes ranging between 204-214 bp, and their distributions were as follows: 210 bp 57.5%, 221 bp 27.9%, 206 bp 13.3% etc. There were no significant differences in BMD of the lumbar spine and proximal femur across the MGP genotypes. No significant differences in the distribution of MGP genotypes among normal, osteopenic, and osteoporotic postmenopausal women were observed. Serum osteocalcin level was significantly higher in women who did not 210 bp MGP (CA) allele than in women carrying at least one copy of this allele, while no significant differences in serum BAP and CTX levels were noted among MGP genotypes. Conclusion: The MGP gene (CA) polymorphism does not affect BMD but serum osteocalcin levels in postmenopausal Korean women.
한국 폐경여성에서 칼슘 감지 수용체 유전자 (CA) 다형성과 골밀도 및 호르몬대체요법에 대한 골 반응도사이의 연관성
김정구 ( Jung Gu Kim ),구승엽 ( Seung Yup Ku ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
Objective : To evaluate the relationship between the calcium sensing receptor (Casr) gene cytosine adenine (CA) polymorphism, bone mineral density (BMD) and bone responsiveness to hormone replacement therapy (HRT). Methods : Casr (CA) polymorphism was ana
체외수정시술시 5 일간의 체외배양을 이용한 포배기 배아 이식술에 관한 연구
김석현(Seok Hyun Kim),구승엽(Seung Yup Ku),지병철(Byung Chul Jee),김은경(Eun Kyung Kim),천은경(Eun Kyung Chun),김희선(Hee Sun Kim),오선경(Sun Kyung Oh),서창석(Chang Suk Suh),최영민(Young Min Choi),김정구(Jung Gu Kim),문신용(Shin Yong 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
Objective : To evaluate the clinical efficacy of human blastocyst transfer following in vitro culture for five days in vitro fertilization and embryo transfer (IVF-ET), and to compare the efficiency of P1-BL and G1-G2 media in the culture of human blastocyst. Methods : Seventy-two infertile patients undergoing blastocyst transfer in IVF-ET were classified into the conventional IVF (n=52) and ICSI (n=20) groups, and P1-BL (n=37) and G1-G2 (n=35) groups. The outcomes of blastocyst transfer cycles were evaluated and compared, respectively. Results : There were no significant differences in the outcomes of controlled ovarian hyperstimulation (COH) and IVF-ET, such as duration of COH, total dosage of gonadotropins used, serum estradiol (E2) level on hCG day, numbers of oocytes retrieved and fertilized, and number of blastocysts transferred between the conventional IVF and ICSI groups, and between P1-BL and G1-G2 groups, respectively. Total blastulation rate was significantly higher in IVF group than ICSI group (53.6% vs. 37.3%, p<0.05). Implantation, clinical pregnancy, and multiple pregnancy rates were significantly higher in IVF group than ICSI group (15.1% vs. 4.1%, p<0.05; 36.5% vs. 15.0%, p<0.05; 36.8% vs. 0%, p<0.01). There were no significant differences in total blastulation, implantation, and clinical pregnancy rates between P1-BL and G1-G2 groups. However, multiple pregnancy rate was significantly higher in G1-G2 group than P1-BL group (60.0% vs. 8.3%, p<0.05). Conclusions : In human blastocyst transfer following in vitro culture for five days in IVF-ET, conventional IVF showed better outcomes of embryo development and pregnancy than ICSI. The efficiency of P1-BL media in the culture of human blastocyst was comparable to that of G1-G2 media. Further investigation will be necessary to compare the efficiency of various media in the blastocyst culture and to confirm the risk of multiple pregnancy in cases using G1-G2 media.