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한국인 태아 및 성인에서 유당분해효소 mRNA 의 발현양상
김재준(Jae Jun Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.5
N/A Objective: The specific activity of lactase-phlorizin hydrolase (LPH) is very high at birth and sharply declines after weaning, producing lactose intolerance. The prevalence of lactose intolerance is up to 85% in Korean adults. Molecular basis of the regulatory mechanisms responsible for the decline of LPH specific activity is still unknown. In order to elucidate the molecular mechanisms regulating the LPH expression during development, LPH specific activity and mI4NA level of Korean fetal and adult intestines were compared. Methods: 20 fetal small intestines (16-27 weeks) were obtained during therapeutic abortion and were divided into 3 equal length. 20 adult jejunal tissues were obtained from patients without small intestinal disease during laparotomy. Mucosal homogenates were prepared for dissacharidases specific activities measurement and total RNA was extracted for northern and slot hvbridization. LPH mRNA level was measured by laser densitometer. Results: LPH specific activities of proximal, middle and distal portion of fetal intestines (n=20) were 36.2±22.5, 38.6±23.2 and 23.2±19.9 mu/mg protein, respectively. LPH specific activity of adult jejunum (n=8) was 5.9±1.8 mu/mg protein and significantly (p<0.05) lower than those of fetal intestines. However, there was no significant difference in sucrase and trehalase specific activities between fetal intestines and adult jejunum. Although LPH specific activity of adult jejunum was lower than those of fetal intestines, LPH mBNA level of adult jejunum was as high as those of fetal intestines. Conclusion: These results show that LPH specific activity and mRNA level do not parallel, indicating the posttranscriptional control of fetal development of LPH expression.
3차원펄스 레이다 신호처리기 분석용 타이밍 신호 발생기의 구현
김재준(Jae-jun Kim),이일근(Ill-Keun Rhee),이영훈(Young-hun Lee) 한국정보기술학회 2006 Proceedings of KIIT Conference Vol.2006 No.-
3차원 펄스 레이다는 표적의 거리, 방위각, 고도를 측정한다. 매우 밀집된 항적 환경에서 고도 자료를 제공해야하는 요구사항을 만족하기위해 2차원 레이다들은 빠르게 3차원 레이다로 대체 되고 있다. 본 논문에서는 3차원 펄스 레이다신호처리기 분석용 타이밍신호 발생기를 제작하였다. 설계 제작된 타이밍 신호 발생기는 실내 환경에서 신호처리기 분석이 가능하도록 3차원 펄스 레이다에 필요한 여러 가지 타이밍 신호와 I/Q 모의 표적 신호를 발생 하는 기능을 제공 할 수 있다. 본 논문은 3차원 펄스 레이다 신호에 필요한 각종 타이밍 신호에 대하여 연구하고 이를 기초로 타이밍발생을 위한 회로 설계 과정과 완성된 회로로부터 측정된 결과들을 제시한다.
김재준 ( Jae Jun Kim ),박찬우 ( Chan Woo Park ),강민지 ( Min Ji Kang ) 한국산림과학회 2010 한국산림과학회지 Vol.99 No.4
The purpose of this study is to survey the current awareness of local officials and to give a proposal that can establish the meaningful directions for the forest landscape policy. The data for this study was collected with questionnaires. Total 232 questionnaires were launched and valid 105 questionnaires were used for analysis. As a result of these data analysis, we found out that their awareness of the importance of forest landscape was high and they thought forest landscape plan was needed. However supply of the information and data such as guidelines to improve forest landscape condition was not enough. Through the IPA method, we had 15 properties of forest landscape policy were settled. It` show us what needs to be kept up the good work, what needs to be concentrated here, what the low priority are, or what the possible overkill are. We finally suggest that direction of forest landscape management should be established based on above investigation.
위식도 역류성 질환의 증상 소실 및 미란성 식도염 치유에 대한 에스오메프라졸 (esomeprazole) 20㎎ 및 40㎎의 효과를 평가하기 위한 공개, 다기관 공동 연구
김재준 ( Kim Jae Jun ),이선영 ( Lee Seon Yeong ),이풍렬 ( Lee Pung Lyeol ),명승재 ( Myeong Seung Jae ),김진호 ( Kim Jin Ho ),최명규 ( Choe Myeong Gyu ),김상우 ( Kim Sang U ),이오영 ( Lee O Yeong ),유종선 ( Yu Jong Seon ),주영은 ( 대한소화기기능성질환·운동학회 2003 Journal of Neurogastroenterology and Motility (JNM Vol.9 No.2
목적: PPI는 위식도 역류성 질환 환자의 식도 점막 손상에 대한 치유 및 증상 개선에 우수한 효과가 있어 치료제로 사용되고 있다. 최근에는 omeprazole보다 산억제 효과가 더 우수하다고 알려진 omeprazole의 S-isomer인 esomeprazole이 개발되어 처방되고 있으나, 아직 한국인에서는 그 효과에 대한 보고가 없다. 이에 연구자들은 한국인 위식도 역류성 질환 환자들에게 esomeprazole을 투여한 후, 식도염 치유율 및 증상 개 Background/Aims: Esomeprazole, an S-isomer of omeprazole, has a potent acid-suppressive effect. It has been prescribed for years, but no reported data had been available with respect to Korean patients. We evaluated the rate of symptom relief, healing rat
김재준(Jae-Jun Kim) 한국산림휴양학회 2009 한국산림휴양학회지 Vol.13 No.4
본 연구는 4개 유형의 산림휴양공간을 대상으로 이용객의 방문 동기요인(push factor)와 이들 산림휴양공간의 방문 유인요인(pull factor)을 도출하고, 방문요인과 유인요인간의 관계규명을 통해 산림휴양공간별 방문선택에 영향을 미치는 요인 파악과 더불어 산림휴양공간별 관리방안 수립의 기초 자료를 제공하고자 수행되었다. 분석 결과 동기요인으로는‘문화 · 자연체험’, ‘성취감’, ‘일탈성’, ‘시간선용’, ‘사회성’등 모두 5개 요인이 도출되었으며, 유인요인으로는‘문화 및 자연자원’, ‘접근성’, ‘편익시설’, ‘체력단련 및 저비용’의 4개 요인이 도출되었다. 이들 동기요인과 유인요인간의 상호 연관성을 통계적으로 분석한 결과 동기요인과 유인요인은 상호 관련이 있는 것으로 나타났다. 이러한 유인요인을 기준으로 동기요인들과의 관계를 살펴보면, 국립공원의‘문화 및 자연자원’유인요인은‘문화·자연체험’, ‘성취감’, ‘사회성’동기에 양(+)의 영향을 받는 것으로 나타났으며, 자연휴양림의‘편익시설’유인요인은 ‘시간선용’, ‘문화·자연체험’등 동기요인에 의해 영향을 받는 것으로 나타났다. 한편, 도시림(산림욕장)의‘접근성’ 유인요인은‘일탈성’및‘시간선용’동기에 양(+)의 영향을 받는 반면, ‘성취감’, ‘사회성’동기에서는 음(-)의 영향을 받는 것으로 나타났다. This study, as a basic survey of management planning for the forest recreations, aimed to identify the push and pull motivators of visitors to the forest recreational area. From four-type forest recreational areas, the nature and extent of the reciprocal relationships between the push and pull factors, were examined as well. As results, five factors, culture and nature experience, sense of accomplishment, escape(deviance), good use of time, and communion, were derived from seventeen push items.ms.ur factors, cultural and natural reactors,, accs,sibltuty, convenience facltutis,, and futns,s and low cost, were derived from twenty pull items.mThe push and pull factors were statistically well correlated and regreased each other. From the relationships between the push and pull factors, pull factors of cultural and natural reactors, in relatal en ks were positively affected on the culture and nature experience, sense of accomplishment, and communion. Pull factors of convenience facltutis, in recreational forests were affected on the good use of time, cultural and nature experience. Finally, pull factor of accs,sibltuty for the urban forests(strolling thrctgh the woods) affected positively on the motivations of escape(deviance) and good use of time, but it did negatively on the sense of accomplishment and communion motivations.
김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),김태호(Tae Ho Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Objectives: The effect of continued supplementation of diet with 10gp sucrose, lactose or glucose solution on rat intestinal disaccharidase specific activity was investigated. Methods: Adult rats were fed a diet with 10% sucrose, lactose or glucose solution supplementation. After 6 weeks, small intestines were removed and disaccharidase specific activities and sucrose mRNA levels were measured. Results: Adult rats when fed a diet with 10% sucrose, lactose or glucose solution supplementation for 6 weeks showed increased intestinal sucrose sperific activity. However, there was no increase of lactase specific activity. Slot blot analysis with radiolabeled rat intestinal sucrase cDNA revealed that mRNA levels of sucrase increased after 10% sucrose, lactose or glucose solution supplementation, and these changes in mRNA levels correlated with the corresponding enzyme specific activity (r=0.36, p<0.05). Conclusion: The results demonstrate that the induction of sucrase activity is directly associated with an increase in sucrase mRNA levels. In conclusion, substrate feeding induces an increase of transcription of rat intestinal sucrase gene.