동산집행의 대상물(1)

김재우 한국사법행정학회 1990 사법행정 Vol.31 No.5

Cyclosporin A가 in vitro에서 조골세포에 미치는 영향

김재우,이현정,강정화,옥승호,최봉규,유윤정,조규성,최성호,Kim, Jae-Woo,Lee, Hyun-Jung,Kang, Jung-Hwa,Ohk, Seung-Ho,Choi, Bong-Kyu,Yoo, Yun-Jung,Cho, Kyoo-Sung,Choi, Seong-Ho 대한치주과학회 2000 Journal of Periodontal & Implant Science Vol.30 No.4

Cyclosporin A(CsA) is an immunosuppressive agent widely used for preventing graft rejecting response in organ transplantation. The basic properties of CsA to osteoblast has not been well known yet. A better understanding of the mechanisms of CsA function on bone could provide valuable information regarding basic properties of bone remodeling, pharmacotherapeutic intervention in metabolic bone disease, and the consequences of immunosuppression in bone physiology. The purpose of this study was to investigate the effect of CsA on osteoblast by evaluating parameters of proliferation, collagen synthetic activity, alkaline phosphatase activity, and ALP mRNA expression in mouse calvarial cell. 1. CsA ($3{\mu}g/m{\ell}$) treated mouse calvarial cell showed statistically significant increase in cell proliferation.(P<0.05) 2. CsA($1,\; 3{\mu}g/m{\ell}$) treated MC3T3 cell line showed statistically significant increase in cell proliferation. 3. The amount of collagen of CsA($3{\mu}g/m{\ell}$) treated mouse calvarial cell was decreased statistically significantly. 4. Alkaline phosphatase activity was increased statistically significantly in CsA treated group($1{\mu}g/m{\ell}$). 5. mRNA expression of ALP was increased in CsA treated group These results suggest that CsA could affect bone remodeling by modulating proliferation & differentiation of osteoblast.

청신경초종 수술 후유증 환자 증례 1례

김재우,현진오,현민경,신원용,임성우,최은영,Kim, Jae-Woo,Hyun, Jin-Oh,Hyun, Min-Kyung,Sin, Won-Yong,Lim, Seong-Woo,Choi, En-Young 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

The purpose of this study is to develop an aproach to diagnosis and treatment of sequelae after removal of vestibular schwannoma through Oriental Medicine. An eighty year-old woman with sequelae after removal of vestibular schwannoma was observed and treated. She had difficulty of hearing, facial nerve palsy, dizziness and was generally weak. She was treated with herb medications for these symptoms. Having been treated for 27 days in hospital her symptoms improved. This report provides evidence for application of herbal medicine in treatment of sequelae. However, more cases are required for an in depth study of oriental treatments for this ailment in order to open this method of treatment to general application.

수근관 증후군 진단에서 수근관절 부목이 정중신경 전도에 미치는 영향

김재우,임훈,박태환,이숙자,김명옥 大韓再活醫學會 1996 Annals of Rehabilitation Medicine Vol.20 No.4

Topical Prostaglandin Analogue Drugs Inhibit Adipocyte Differentiation

김재우 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.3

Purpose: To investigate the effects of topical prostaglandin analogue drugs on the differentiation of adipocytes. Methods: Differentiation of 3T3-L1 preadipocytes was induced with isobutylmethylxanthine, dexamethasone,and insulin. 3T3-L1 cells were exposed to 0.008, 0.08, 0.2 mM of latanoprost and travoprost. Reverse transcriptionpolymerase chain reaction for mRNA expression of lipoprotein lipase and peroxisome proliferator-activatedreceptor γ 2 (PPARγ2), and glycerol-3-phosphate dehydrogenase (G3PDH) assays were performed toexamine the effects on early and late differentiation, respectively. Also, glycerol assays were done to evaluatethe effect of prostaglandin analogues on lipolysis after differentiation. Results: Both prostaglandin analogues inhibited differentiation of preadipocytes. Topical prostaglandin analoguessignificantly decreased G3PDH activity, a marker of late differentiation. However, topical prostaglandinanalogues did not change mRNA expressions of lipoprotein lipase and PPARg2, markers of early differentiation. The activities of the early markers of differentiation were not changed significantly before and aftergrowth arrest. Compared to latanoprost, travoprost decreased G3PDH activity more significantly (p < 0.05). Both prostaglandin analogues did not affect the lipolysis of differentiated adipocytes (p > 0.05). Conclusions: Prostaglandin analogues display an inhibitory effect on the differentiation of adipocytes when thecells start to differentiate especially in the late stage of differentiation. Thus, commercial topical prostaglandinanalogues may decrease the fat contents of eyelids.

근 긴장 이상증의 신경생리

김재우 대한임상신경생리학회 1999 Annals of Clinical Neurophysiology Vol.1 No.2

Dystonia is a movement disorder characterized by sustained, involuntary muscle contractions leading to abnormal postures. Using EMG recordings, three types of involuntary activity can be seen in dystonia. There are abnormalities in many different types of reflexes in dystonia. In view of the strong connection between the basal ganglia and motor areas of the cerebral cortex, there have been several investigations suggesting defects in cortical function including movement-related cortical potentials and contingent negative variation in patients with dystonia. Although dystonia is considered as a movement disorder, there are several phenomena relating to the sensory system that might suggest that dystonia could be primarily a sensory disorder. It is suggested that loss of inhibition from basal ganglia both at the cortical level and brainstem and spinal cord leading to defective control of interneuronal excitability be an important role for the pathogenesis of dystonia.

중학교 과학 영재와 대학생들의 힘 개념 비교

김재우 한국물리학회 2009 새물리 Vol.58 No.4

The purpose of this study was to compare the concepts on force between scientifically-gifted and college students and to determine the implications for setting the curriculum for gifted students. For doing this, FCI questionnaires, which had been slightly modified from the original format, were used. The subjects of this study were 101 gifted middle-school students attending the Education Center of Gifted Students in Seoul and 35 college students. The average correct answer rate was 63% for gifted students and 70% for college students. The results were analyzed by comparing the distributions of answers of the gifted students and the college students. This showed that 65% of the gifted students had little understanding of the kinds and magnitudes of forces acting on a body at rest or a moving body and that their correct answer rate was higher than that of college students for problems in science textbooks (circular motion, motion of a pug on ice). The gifted students' correct answer rate was lower than that of college students for action-reaction problems not treated in the national curriculum. The results of this study suggest that the curriculum for the scientifically gifted should include programs that consider the understanding of students about the kinds and magnitudes of forces in dynamic situations. 본 연구의 목적은 영재교육을 이수한 학생들의 힘 개념을 조사하고 그 결과를 과학교육을 전공하는 대학생들과 비교하여 영재교육과정의 설정에 필요한 시사점을 얻는 것이다. 이를 위하여 서울 소재 지역교육청에서 영재교육을 받는 중학교 2학년 학생 101명과 서울소재 대학교의 과학교육과 학생 35명을 대상으로, FCI 중 연구자가 교육과정 비관련부분을 제외하여 만든 검사지를 투입하고 그 결과를 분석하였다. 연구 결과 영재학생의 정답률은 63%, 대학생의 정답률은 70% 정도였다. 국가교육과정에서 취급하지 않는 작용-반작용의 문제의 경우에는 중학생들의 정답률이 상대적으로 낮았으며, 원운동이나 얼음판에서의 관성 운동과 같이 교육과정에서 취급되는 문제의 경우에는 중학생들의 정답률이 높았다. 또한 일정한 속력으로 움직이는 물체에 작용하는 경우 힘의 종류와 크기 비교, 운동하는 물체에 작용하는 힘의 종류에 대한 문제의 경우에는 약 65% 정도의 학생들이 적절한 이해를 갖지 못하고 있는 것으로 나타났다. 따라서 영재들을 대상으로 하는 힘과 운동 학습에서는 이러한 측면을 보완할 수 있는 수업 방법 및 교육과정이 요구된다.

한국 국민의 국가암검진사업 인지와 수검의도간의 관련성 : 온라인 설문을 중심으로

김재우,김성호,강정규 보건의료산업학회 2016 보건의료산업학회지 Vol.10 No.4

Objectives : The aim of this study was to investigate the degree of awareness of the national cancer screening program by the Korean public and define its relationship with cancer screening intention. Methods : The study collected data by conducting an online survey from April 19 to 24, 2016, and received a total 354 responses. Additionally, we performed frequency analysis, chi-square test, and logistic regression analysis. Results : Based on the results for the degree of awareness for the national cancer screening program, 151 (42.7%) people were aware of the program, while 203 (57.3%) were not aware the program. From the chi-square test and logistic regression analysis, marital status and awareness of the national cancer screening program were found to have a statistically significant influence on screening intention. Conclusions : An increase in the screening rate should be established with a systematic promotion plan for the national cancer screening program.

소설교육과 매체활용 문제

김재우 배달말교육학회 2010 배달말교육 Vol.31 No.-

고포도당이 섬유주세포의 산화스트레스에 미치는 영향

김재우,배창범,이정훈 대한안과학회 2009 대한안과학회지 Vol.50 No.10

목적: 고포도당이 섬유주세포의 산화스트레스에 미치는 영향을 알아보고자 하였다. 대상과 방법: 일차배양 섬유주세포를 고농도(25 mM)와 저농도(5 mM)의 포도당이 포함된 배지에 각각 7일간 노출시켰으며 Larginine, DAHP, insulin, 아스코르빈산, sepiapterin에도 노출시켰다. 세포생존과 일산화질소 생성, superoxide 생성을 MTT, Griess, modified cytochrome c assay로 측정하였다. 결과: 고포도당은 섬유주세포의 생존에는 유의한 영향을 미치지 않았으나 일산화질소의 생성을 유의하게 억제하였고 동시에 노출한 DAHP는 일산화질소의 생성을 더욱 억제하였으나 insulin과 sepiapterin은 일산화질소의 생성을 증가시켰다. 고포도당은 superoxide의 생성을 증가시켰으며 insulin과 아스코르빈산, sepiapterin은 superoxide의 생성을 감소시켰다. 결론: 고포도당은 섬유주세포에서 일산화질소의 생성을 억제하는 동시에 superoxide의 생성을 증가시켰다. 고포도당은 섬유주세포에서 산화스트레스를 유발하여 섬유주의 손상과 기능저하를 초래할 수 있을 것이다. Purpose: To investigate the effect of high glucose (HG) on the oxidative stress in cultured human trabecular meshwork cells (HTMC). Methods: Primarily cultured HTMC were exposed to low glucose (5 mM) and HG (25 mM) for 7 days. Additionally, 1 mM Larginine, 5 mM DAHP, 10 μg/ml insulin, 100 μM L-ascorbic acid, 10, and 100 μM sepiapterin were co-exposed. The cellular survival and nitric oxide (NO) production were assessed by MTT assay and Griess assay, respectively. Superoxide production was measured by modified cytochrome c assay. Results: HG did not affect the survival of cultured HTMC significantly. HG decreased NO production. Co-exposed DAHP decreased but DAHP and insulin increased NO production. In addition, HG increased superoxide production, which was decreased by insulin, L-ascorbic acid, and sepiapterin. Conclusions: HG decreased NO production accompanied with increased superoxide production in HTMC. Thus HG induces oxidative stress in HTMC and may cause cellular dysfunction and damage of the trabecular meshwork.