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김인겸,양은경,Kim, In-Kyeom,Yang, Eun-Kyoung The Korean Society of Pharmacology 1996 대한약리학잡지 Vol.32 No.3
패혈증 환자에 흡입마취제를 투여하는 것은 혈역동학에 심각한 영향을 초래할 수 있다. 흡입마취제 투여시 내독소혈증흰쥐 대동맥 수축반응에 미치는 hydroxocobalamin의 영향을 알아보기위해, 내독소 (1.5 mg/kg)를 복강내 투여한 뒤 18시간 후에 대동맥을 적출하여 phenylephrine에 대한 수축반응과 이에 대한 흡입마취제 및 hydroxocobalamin의 작용을 알아보았다. 패혈증이 적절히 유발되었는 지를 확인하기 위해 RT-PCR을 이용하여 혈관 평활근에서 iNOS유도를 확인하였다. 내독소 처치에 의해 수축기 및 확장기 혈압이 대조군에 비해 유의하게 감소되었으나, 심박동수는 영향이 없었다. Phenylephrine에 대한 수축반응은 $10^{-8}\;M$부터 $10^{-5}\;M$까지 용량 의존적으로 증가했으며, 내독소혈증흰쥐 대동맥에서 수축반응이 억제되었다. halothane과 enflurane은 1 MAC 농도에서 phenylephrine에 의한 수축반응을 유의하게 억제했으나 isoflurane은 영향이 없었다. Hydroxocobalamin $(10^{-5}\;M)$은 흡입마취제의 종류 및 투여 유무에 관계없이 내독소혈증흰쥐 대동맥 수축반응을 증가시켰다. 이상의 결과로 미루어보아 hydroxocobalamin은 패혈증 환자의 흡입마취시 혈역동을 개선시킬 것으로 사료된다. The hemodynamic changes in septic patients produced by inhalational anesthetics are sufficient to threaten the anesthesiologists. The effect of hydroxocobalamin, a vitamin $B_{12a}$, on contractile responses to phenylephrine during administration of inhalational anesthetics were evaluated in aortic ring preparations obtained from LPS-treated rats. The sepsis was developed by intraperitoneal injection of LPS (1.5 mg/kg for l8h) and confirmed by iNOS expression using RT-PCR. Statistical significances (P<0.05) were analyzed by Student's t-test or paired t-test according to data characteristics. The blood pressure, but not heart rate, was decreased in LPS-treated rats as compared to control rats. The contractile response to phenylephrine were dose-dependently increased from the doses of $10^{-8}\;M$ to that of $10^{-5}$ and were attenuated in LPS-treated rings. Both halothane and enflurane, at the doses of 1 MAC, decreased the contractile responses to phenylephrine while isoflurane did not significantly affect the contractile responses. Hydroxocobalamin ($10^{-5}$ M) significantly potentiated the contractile responses in the LPS-treated aortic ring preparations during administration of each inhalational anesthetic or not. From these results, it is suggested that hydroxocobalamin may improve the hemodynamics of septic patients during inhalational anesthesia. Abbreviations: LPS, lipopolysaccharide; RT-PCR, reverse transcription-polymerase chain reaction; MAC, minimum alveolar concentration; iNOS, inducible nitric oxide synthase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase
김인겸 聖潔大學校 情報産業技術硏究所 1999 情報産業技術論叢 Vol.4 No.-
In this paper, it is presented the characteristics of the signal fading in three propagation environment. At first, the fading of a propagation signal is experimented in LOS(Line of Sight) regions without any obstacle. In the second, the signal fading is experimented in residential regions which have various houses and apartments. Finally signal fading is measured in the center of the city that have various markets, offices, and buildings. The fading of measured signals is very compatible in the existent propagation models. Especially the doppler effect is verified in the LOS region. The large scale fading and small scale fading are verified in the experimented data in the high frequency propagation environment for IMT-2000.
내부냉각 노즐 베인 열차폐코팅 적용을 위한 전산해석기법 연구
김인겸,김진욱,이동호,조진수 한국항공우주학회 2014 한국항공우주학회 학술발표회 논문집 Vol.2014 No.11
본 연구에서는 내부냉각이 적용되는 NASA의 C3X 베인을 사용하여 베인 표면에 열차폐코팅(TBC)을 모델링하는 전산해석기법을 연구하였다. Ansys CFX 15.0의 thin material 기법을 사용해서 20 mol.% yttria stabilized zirconia(YSZ)의 두께가 0.1 mm, 0.2 mm, 0.3 mm인 TBC 층을 모델링했다. 복합열전달 해석기법을 사용하여 압력 및 온도 특성을 분석하였다. 해석 결과 TBC의 두께와 무관하게 베인 표면 압력은 일정하게 나타났다. 베인 표면 온도는 TBC 층의 두께가 증가함에 따라 베인 표면 전 구간의 온도가 감소했다. 베인 표면 평균온도는 TBC 층의 두께가 0.1 mm 증가할 때마다 약 3~4도씩 감소하였다. 또한, 베인 내부 온도도 TBC 층의 두께가 증가함에 따라 감소하였다. A computational fluid dynamics analysis method for modeling thermal barrier coating (TBC) layer using the internal cooled NASA C3X Vane was performed. Thin material method in Ansys CFX 15.0 was used to model 0.1 mm, 0.2 mm and 0.3 mm thick TBC layer by utilizing 20 mol.% yttria stabilized zirconia(YSZ) material. The pressure and the temperature characteristics were analyzed using conjugate heat transfer (CHT) method. It was observed that there was no change in the pressure on the vane surface by changing layer thickness of TBC. Furthermore, as the TBC layer thickness was increased by 0.1mm the averaged vane surface temperature was decreased about 3-4 degree Kelvin. The internal vane temperature was also decreased with the TBC layer thickness increases. The modeled TBC layer can be used for vane cooling applications.
강수확률예보 만족도 제고를 위한 정책방안 : 2004∼2013년 서울과 부산을 중심으로
김인겸,안숙희,이승욱,박기준,김정윤,김백조,이기광 건국대학교 기후연구소 2014 기후연구 Vol.9 No.3
In this study, instead of economic estimation of forecast value, we evaluated the value score(VS) of the user satisfaction using the concept of satisfaction/dissatisfaction. We compared the collective Value Scores (cVS) based on outputs of probabilistic forecasts of precipitation seasonally in Seoul and Busan during the period of 2004 to 2013 and ÿnally found the optimum threshold that can improve cVS of both cities. When using 30% threshold, the users can expect a higher cVS compared with those using other thresholds. When using the seasonal optimum threshold in Seoul, the cVS is additionally higher by 9%. These results show the level of satisfaction of the forecast that can be improved when the meteorological communities inform the users the correct threshold of the rainfall probabilistic forecast.
김인겸 聖潔大學校 情報産業技術硏究所 1998 情報産業技術論叢 Vol.3 No.-
In this thesis, a new convex set based on POCS theory is proposed employing an edge-block-smoothing convex set for efficient processing of blocks having diagonal edge. The proposed method is aimed at removing blocking artifact in very low bit-rate coding. First, edge detection is performed on the block. The block is classified according to the direction of the edge within the block as vertical-edge block, horizontal-edge block, or diagonal-edge block. For diagonal-edge block, a blurring process is performed in the direction of the edge to remove blocking artifacts along the edge. The conventional methods do not consider the direction of the edge and the blocking artifacts are not effectively removed for diagonal edge. Experimental results show that the performance of the proposed method is superior to that of conventional method by retaining the high frequency elements while removing blocking artifacts especially for diagonal-edge block. The proposed method can be applied to the post processing of the block-based image coding.