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Henoch-Schoenlein증후군에 대한 임상적 관찰
김이우,박성태,백철홍,오지섭,신동학 계명대학교 의과대학 1994 松年 申東鶴 敎授 停年退任紀念 論文集 Vol.1 No.-
The clinical studies of 30 cases of Henoch-Schoenlein syndrome in infancy and children were made. 1) The previous history of the upper respiratory tract infection showed 83.3%. 2) Males were more affected than females. The ratio was approximately 2: 1. 3) In age incidence, the cases were seen mostly from 2 to 8 year(70.0%), especially from 4 to 6 year of Iife(33.3% ). 4) Seasonal incidence was more common in spring 15 cases and fall months 8 cases. 5) Clinical manifestations were skin rash( 100.0%), joint pain(70.0%), abdominaI{63.3%) and nephritis (26.7% ). 6) The most common type of skin rash in Henoch-Schoenlein syndrome was petechiae on the area below the waist, especially buttocks. 7) Joints most often involved were the ankle and knee(85.7%), less frequently the wrists and digits. 8) In gastrointestinal manifestation of Henoch-Schoenlein syndrome, abdominal pain was the most com mon(84.2%) and next gastrointestinal bleeding(78.9%). 9) The renal manifestation of Henoch-Schoenlein syndrome was the most serious sign. Hematuria was more common than albuminuria(75.0%) in these cases. 10) Most cases(28 of 30) were recovered within 6 weeks and one case of nephritis was recovered within 8weeks, but only one case of nephritis was not recovered.
배영숙,홍영숙,김환권,김이우 中央醫學社 1989 中央醫學 Vol.54 No.10
The effect of intraperitonelly administered nifedipine, an antiphypertensive medication on the mixed-function oxidase system components, such as cytochrome P-450, cytochrome b5, NADPH- and NADH-cytochrome C reductause, p-nitroanisole-O-demethylase, and the formation of lipid peroxide and UDP-glucuronosyltransferase in the spontaneous hypertensive rat hepatic microsomes were investigated. The result is as follows: 1. After 3-7 day of nifedipine injection bidaily, the contents of cytochrome P-450 and b5 were slightly increased and after 4 weeks of nifedipine injection bidaily, the contents of cytochrome P-450 and b5 were increased significantly. 2. After 2 and 4 weeks of nifedipine injection bidaily, the activities of NADPH- and NADH-cytochrome C reductase were increased significantly. 3. After 2 and 4 weeks nifedipine injection bidaily, the activities of monooxygenase, p-nitroanisole-O-demethylase were increased significantly. 4. The formation of lipid peroxide did not change for 4 weeks injection bidaily. 5. After 2 and 4 weeks of nifedipine injection bidnily, the activity of UDP-glucuronosyltransferase was increased markedly.