항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석

김은혜,윤지현,이지영,윤성우,Kim, Eun Hye,Yoon, Jee-hyun,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2020 大韓癌韓醫學會誌 Vol.25 No.2

Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

마찰접합 된 A6063 합금의 미세조직과 기계적 특성 평가

김은혜,조형환,송국현,Kim, Eun-Hye,Cho, Hyung-Hwan,Song, Kuk-Hyun 한국재료학회 2017 한국재료학회지 Vol.27 No.5

This study was carried out to evaluate the developed microstructures and mechanical properties of friction welded A6063 alloy. For this work, specimens were prepared at a size of 12 mm ${\O}{\times}80mm$, and friction welding was carried out at a rotation speed of 2,000 RPM, friction pressure of $12kgf/cm^2$ and upset pressure of $25kgf/cm^2$. To perform an analysis of the grain boundary characteristic distributions, such as the grain size, orientation and misorientation angle distributions, the electron back-scattering diffraction method was used. In addition, in order to identify the dispersed intermetallic compounds of the base and welded materials, transmission electron microscopy was used. The experimental results found that the application of friction welding on A6063 led to significant grain refinement of the welded zone relative to that of the base material. Besides this, intermetallic compounds such as AlMnSi and $Al_2Cu$ were found to be dispersed with more refined size relative to that of the base material. This formation retains the mechanical properties of the welds, which results in the fracture aspect at the base material zone. Therefore, based on the developed microstructures and mechanical properties, the application of friction welding on A6063 could be used to obtain a sound weld zone.

청소년이 지각한 사회적 자본이 유데모니아에 미치는 영향: 인권의식을 매개로

김은혜,손한결,Kim, Eun Hye,Sohn, Han Gyeol 한국학교ㆍ지역보건교육학회 2021 한국학교지역보건교육학회지 Vol.22 No.3

Objectives: The purpose of this study was to examine the mediating effect of human rights consciousness on the relationship between social capital and eudaimonia perceived by adolescents. Methods: The participants of this study were 9,021 adolescents, with data taken from the 6^th year(2018) panel survey. All variables were evaluated by self-report of adolescents. The data were analyzed by SPSS 21.0 and AMOS 21.0. Results: First, social capital perceived by adolescents had a direct effect on eudaimonia. Second, social capital perceived by adolescents had an indirect effect on the eudaimonia through human rights consciousness. Conclusions: This study highlighted that human rights consciousness was identified as important mediator in the relationship between capital perceived by adolescents and eudaimonia. These results can be used as an important contribution to further research and educational practices for promoting the eudaimonia in adolescents.

전이 췌장암 환자의 Gemcitabine과 방암탕 가감방 및 건칠단 병용투여 치험 1례

김은혜,윤성수,이지영,윤성우,Kim, Eun Hye,Yoon, Sung Soo,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2018 大韓癌韓醫學會誌 Vol.23 No.2

Objectives: This study was aimed to report a patient with metastatic pancreatic cancer treated with modified Bangam-tang and Gunchil-dan in conjunction with gemcitabine. There were better survival-related outcomes compared to gemcitabine alone. Methods: The patient with metastatic pancreatic cancer received gemcitabine as palliative chemotherapy since June 2016 concurrent with modified Bangam-tang and Gunchil-dan since October 2016 to October 2017. To evaluate the effect of treatment, tumor markers (carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA)), Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and overall survival were checked. Adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Results: After 12 months with the combination treatment, levels of CA19-9 were decreased from 8747 to 265.7 ng/ml and CEA from 42.2 to 6.5 U/ml. Clinical partial response state was shown until May 2, 2017 and stable disease state was maintained from August 4, 2017. In March 2018, the patient got an operation including pancreatectomy and diagnosed with no evidence of disease state in September, 2018. In conclusion, it showed the overall survival of 29 months from June, 2016 to November, 2018. Serious adverse events were not identified. Conclusions: This study suggested that combined treatment with modified Bangam-tang and Gunchil-dan may show better outcome in patient with metastatic pancreatic cancer than gemcitabine alone.

겹치기 마찰교반접합 된 Al6061/HT590 합금의 기계적 특성 평가

김은혜,이광진,송국현,Kim, Eun-Hye,Lee, Kwang-Jin,Song, Kuk-Hyun 대한용접접합학회 2015 대한용접·접합학회지 Vol.33 No.2

This study was carried out to evaluate mechanical properties of the jointed Al6061/HT590 alloys by friction stir welding (FSW). FSW was conducted under the conditions with tool rotating speed of 500 RPM and traveling speed of 300 mm/min., where Ar gas was introduced to prevent the materials from corrosion during the welding process. Electron back-scattering diffraction (EBSD) was used to characterize microstructures such as grain size, misorientation angle and crystal orientation. Evolution of intermetallic compounds in Al6061 during the process were examined in terms of morphology, size and aspect ratio at three distinct zones Al base material, heat affected zone and stir zone, where transmission electron microscope (TEM) was used. It was revealed that FSW gave rise to refinement of grains as well as growth of intermetallic compounds in Al6061. The morphological changes of intermetallic compounds exerted an influence on mechanical properties, resulting in occurrence of fracture in the part of the base material instead of the jointed parts (heat affected zone and stir zone). This study systematically evaluated the microstructural evolutions during the FSW for joining Al6061 with HT590 and their effect on mechanical properties.

한국 성인의 수면시간과 체성분 인자와의 연관성

김은영(Eun Young Kim),최윤선(Youn Seon Choi),김선미(Seon Mee Kim),최선영(Sun Young Choi),김은혜(Eun Hye Kim),김정은(Jung Eun Kim),김이연(E Yeon Kim),정재훈(Jae Hoon Jeong),진로사(Rosa Jin),정상아(Sang Ah Jung) 대한임상노인의학회 2014 대한임상노인의학회지 Vol.15 No.1

연구배경: 수면부족은 당 대사조절 등 체내 생리적 시스템에 영향을 주면서 비만의 유병률을 높일 것으로 생각되는데, 국내외적으로 수면시간과 비만과의 연관성을 다룬 연구는 많이 있으나 체지방량의 분포 등 체성분과의 연관성을 다룬 연구는 거의 없는 실정 이다. 이에 본 논문에서는 우리나라 성인의 수면시간과 체성분과의 연관성을 확인하고자 했다. 방법: 제 4기(2008∼2009)와 제 5기(2010) 국민건강영양조사 자료를 분석하였으며 고령, 미측, 갑상샘 질환, 신부전, 임신을 제외한 총 9880명을 대상으로 하였다. 체성분인자로 BMI, 허리둘레, 총체지방률, 몸통체지방률, 제지방률, 몸통제지방률, 근량을 사용하였고, 수면시간에 따른 체성분 분석의 연관관계를 보기 위해 선형 회귀분석 및 로지스틱 회귀분석을 이용하였으며, 나이, 흡연, 운동, 음주 등의 교란변수를 보정하여 다중 로지스틱 회귀분석을 실시하였다. 결과: 남성과 여성 모두 BMI, 허리둘레, 몸통체지방률, 근량에서 수면시간과 유의한 음의 상관관계를 보였으며, 비만 관련 위험도를 알아보기 위하여 BMI≥25 kg/㎡, 허리둘레(남자≥90 cm, 여자≥85 cm), 체지방률과 제지방률, 근량의 상위 25%값의 비율에 대해 다중 로지스틱 회귀분석을 실시하였을 때는, 남성에서만 유의한 교차비를 보였다. 남성에서 수면시간이 1시간 증가할수록 BMI 25이상의 위험은 0.89배, 허리둘레 90 cm이상 위험은 0.90배, 몸통 체지방률과 근량도 각각 0.93배, 0.89배 감소하였다. 결론: 우리나라 성인의 수면시간은 체성분인자 중 BMI, 허리둘레, 몸통 체지방률, 몸통 제지방률, 근량과 유의한 연관성이 있었으며, 남성에서는 수면시간이 부족할수록 BMI 25 kg/㎡ 이상, 허리둘레 90 cm이상 될 위험이 증가하고, 몸통체지방률이 증가할 위험도 높은 것으로 나타났다. 이러한 결과는 수면부족이 몸통에 체지방량의 분포를 증가시켜 중심비만을 야기시키는 원인이 될 수 있음을 뒷받침하며, 적절한 수면관리를 통해 이를 예방할 수 있을 것으로 사료되므로 이를 지키기 위한 노력이 필요하겠다. Background: Despite the large number of epidemiological studies linking obesity and short sleep duration, there is paucity of data carefully examining the relationship between body composition and sleep duration. So, through national undertaking Korea National Health and Nutrition Examination Surveys (KNHANES), we examined the relationship between sleep duration and BMI, waist circumference, and percent body fat in Korean adults. Methods: From the data of KNHANES in the year of 2008∼2010, over 19 years old 4337 men and 5543 women, relationship between sleep duration and indices of body composition was examined. Anthropometric and dual-energy X-ray absorptiometry (DXA) measures of body composition were used. Sleep duration was measured using information obtained from self-reported questionnaires. Results: The study results revealed a negative association between sleep duration and most of body composition variables - body mass index, waist circumference, truncal fat percentage, muscle mass - and positive association with truncal lean mass percentage. In men, increasing sleep duration 1 hour, prevalence of obesity (BMI≥25 kg/㎡) is decreasing (OR=0.89, CI:0.837-0.939), risk of waist circumference over 90 cm is decreasing (OR=0.90, CI:0.851-0.966), truncal fat percentage (OR=0.93, CI:0.869-0.992) and muscle mass (OR=0.89, CI: 0.835-0.949) are also decreasing. Conclusion: Our results are consistent with previous findings that sleep duration is associated with obesity. However, the relationship between sleep duration and body composition may be stronger in men than in women. Short sleep duration was associated with increased truncal fat. And it supports that short sleep duration may increase prevalence of central obesity in Korean men.

다문화 청소년의 자아존중감, 신체만족도, 학교생활적응 간의 종단적 상호인과관계

김은혜(Kim, Eun Hye),최려나(Cui, Lina),노충래(Nho, Choong Rai) 한국아동복지학회 2021 한국아동복지학 Vol.70 No.3

본 연구는 다문화 청소년의 자아존중감, 신체만족도, 학교생활적응 간의 종단적 상호인과관계를 살펴보고 이에 따른 다문화 청소년 복지의 함양을 위한 방안을 모색하는 것이다. 이를 위해 다문화청소년패널데이터(MAPS) 중 초·중학생의 전환기 시기인 3∼5차년도 데이터를 자기회귀교차지연모형을 통해 분석하였으며, 다문화 아동 1,307명이 연구대상이다. 연구결과, 첫째, 초등학교 6학년부터 중학교 2학년까지의 세 변인인 자아존중감, 신체만족도, 학교생활적응의 자기회귀경로에서, 이전 시점의 자아존중감, 신체만족도, 학교생활적응이 각각 이후 시점에 유의하게 영향을 미치는 것으로 나타났다. 둘째, 자아존중감과 신체만족도 간에는 종단적 상호인과관계가 유의하게 영향을 미쳤으며, 또한 자아존중감과 학교생활적응 간에도 종단적 상호인과관계가 있음을 확인하였다. 하지만 신체만족도와 학교생활적응 간에서는 학교생활적응은 신체만족도에 유의한 영향을 미쳤으나, 신체만족도는 학교생활적응에 유의한 영향을 미치지 않는 것으로 나타났다. 이러한 결과를 바탕으로 다문화 아동·청소년 복지의 함의를 논하였다. The purpose of this study was to explore longitudinal reciprocal effects between self-esteem, body satisfaction, and school adjustment and to discuss implications for the social welfare of adolescents from multicultural families. For this purpose, we used data from the third (2012), the fourth (2013), and fifth (2014) waves of the Multicultural Adolescents Panel Study (MAPS). An autoregressive cross-lagged model was used to test reciprocal effects, and 1,307 adolescents responded to the three above-mentioned waves of MAPS. The findings were as follows. First, self-esteem, body satisfaction, and school adjustment in the third wave had significant effects on self-esteem, body satisfaction, and school adjustment in the fourth and fifth waves, respectively. Second, there was a statistically significant longitudinal reciprocal relationship between self-esteem and body satisfaction. In addition, self-esteem had a significant longitudinal reciprocal relationship with school adjustment. However, school adjustment had a statistically significant longitudinal effect on body satisfaction, but not vice versa. On the basis of the results, we offer suggestions to improve self-esteem, school adjustment, and body satisfaction among adolescents from multicultural families.

시지각 프로그램이 경직성 뇌성마비 아동의 글씨 쓰기 명료도와 시지각 능력에 미치는 영향

김은혜 ( Eun Hye Kim ),배민정 ( Min Jung Bae ),전현용 ( Hyun Yong Jun ),장철 ( Chel Jang ),송민옥 ( Min Ok Song ) 대한통합의학회 2015 대한통합의학회지 Vol.3 No.1

Purpose: This study intends to investigate if visual perception training program has influence on writing intelligibility and visual perception ability of the children who have spastic cerebral palsy. Methods: The subjects were 12 children of 4-8 years old. Classifying them into 2 groups - cerebral palsy children group(6) and normal children group(6), visual perception training program was conducted to the cerebral palsy children group twice a week for 4 weeks. Korean alphabet writing test and Korean-version development test on visual perception(DTVP-2) were used for the test. Result: First, the cerebral palsy children group had significantly lower scores on visual perception than the normal children group. Second, Two groups didn`t show significantly difference between before and after the visual perception training program. Third, The normal children group significantly increased at three parts without the visual perception training program. Forth, The cerebral palsy children group significantly increased at the only a part after the visual perception training program Conclusion: For the visual perception ability improvement of cerebral palsy children, it is necessary to systematic and continued intervention. And the study about the effect of the visual perception training program application according to by type characteristic of the cerebral palsy child wishes to proceed.

방사선사 직무수행을 위한 방사선사 단독법 제정에 대한 요구도

김은혜(Eun-Hye Kim),임청환(Cheong-Hwan Lim),임우택(Woo-Taek Lim),주영철(Young-Cheol Joo),홍동희(Dong-Hee Hong),정홍량(Hong-Ryang Jung),문영주(Young-Ju Moon),김훈(Hoon Kim),정영진(Young-Jin Jung),최지원(Ji-Won Choi),윤용수(Yong-Su Yo 대한방사선과학회(구 대한방사선기술학회) 2021 방사선기술과학 Vol.44 No.5

In order to provide high-quality medical services to the public and contribute to the improvement of public health, it is necessary to enact an independent law according to the work of radiological technologists. Therefore, this study intends to review the regulations related to radiographers in the Medical Service Technologists, etc. Act. and to present opinions and directions for enactment of individual laws for radiological technologists. An online survey was conducted to 15,000 radiological technologists working in medical institutions and education sites in Korea; 1,027 people (6.85%) responded. The questionnaire consisted of 3 questions on demographic characteristics, 5 questions on the scope of work, and 12 questions on the revision of the Medical Service Technologists, etc. Act. and the establishment of the Radiological Technologist Independent Act. Reliability and factor analysis were performed on 9 questions measured on a Likert 5-point scale in “Revision of the Medical Service Technologists, etc. Act. and the establishment of the Radiological echnologist Independent Act” among the questionnaire items. Reliability for the total 9 questions was Chronbach α=0.728. There was a high perception that the regulations related to radiological technologists were insufficient in the current Medical Service Technologists, etc. Act., and the perception that examinations performed by radiological technologists at medical institutions were included in medical practice was high. If the Radiological Technologist Independent Act is enforced, a high percentage of respondents said that they could receive legal protection through the institutionalization of the scope of work, that the status of radiological technologists would be improved, and the scope of work would be expanded. The response that the scope of work of radiological technologists should be included was the highest at 96.6%. In the analysis according to demographic characteristics, it was found that 96.7% of the respondents were agreed regardless of the factors. Radiological technologists will have to work hard to secure the public health by coping with new radiology devices, procedures and treatment methods. Therefore, as the results of this study, it is expected that the enactment and implementation of the Radiological Technologist Independent Act will contribute to the improvement of the quality of treatment for patients and to the public health.

이모티콘 이용에 대한 동조 욕구와 독특성 추구 욕구가 유료이모티콘 구매 의도에 미치는 영향 : 한·중 간 문화 비교

김은혜(Kim, Eun-hye),이희태(Lee, Hee Tae),정보희(Jung, Bo-hee) 한국상품학회 2020 商品學硏究 Vol.38 No.1

본 연구는 모바일 인스턴트 메신저(Mobile Instant Messenger; MIM) 내 이모티콘 이용 동기로 이모티콘 이용에 대한 동조욕구와 독특성 추구 욕구를 제안하고, 이들 동기가 유료 이모티콘 구매의도에 어떠한 영향을 미치는지에 대해 한국 및 중국 소비자를 대상으로 비교연구를 진행하였다. 연구의 주요 분석결과를 요약하면 다름과 같다. 이모티콘 사용에 대한 소비자의 동조 욕구는 이모티콘 구매의도에 유의미한 정(+)의 영향을 미치고 있음을 확인할 수 있었다. 즉 이모티콘 사용에 대한 동조 욕구가 높을수록 구매의도도 높아짐을 실증적으로 검증하였다. 그러나 이러한 동조의 효과는 한국에서만 나타나고 있으며, 중국에서는 발생하지 않았다. 반면, 독특성 추구 욕구가 이모티콘 이용 행동에 미치는 영향은 한국과 중국 모두에서 유의미하게 나타났다. 즉 MIM 내 이모티콘 이용에 있어 독특성 추구 욕구가 높을수록 이모티콘 구매의도도 높게 나타났다. 마지막으로 MIM 내 이모티콘 이용 동기로서 동조 욕구와 독특성 추구 욕구가 이모티콘 구매의도에 미치는 영향은 문화 차이(한국 vs. 중국)에 의해 조절됨을 확인하였다. 보다 구체적으로 한국 소비자가 중국소비자에 비해 이모티콘 사용에 대한 동조 욕구와 독특성 추구 욕구가 구매의도에 미치는 영향이 더 크게 나타났다. 마지막으로 이러한 결과를 바탕으로 한 본 연구의 이론적, 실무적 함의에 대해 논의하였다. Based on social influence perspectives, we aimed to empirically investigated the effect of needs for conformity and needs for uniqueness as one of important emoticon usage motives on emoticon purchase intentions for MIM(mobile instant messenger). Also we verified the moderating role of cultural difference(Korea vs. China) on the relationship between these emoticon usage motives(e.g. needs for conformity and needs for uniqueness of using emoticon) and emoticon purchase intentions. As a result of the analysis, needs for conformity positively impacts on emoticon purchase intentions only for Korean. However, there was no significant main effect of needs for conformity on emoticon purchase intentions for Chinese. Needs for uniqueness of using emoticon positively affect emoticon purchase intentions in both Korean and Chinese consumers. The finding also showed that the effect of needs for conformity and needs for uniqueness of using emoticon on emoticon purchase intentions was moderated by cultural difference between Korea and China. In line with our predictions, the main effect of needs for conformity and needs for uniqueness of using emoticon on emoticon purchase intention was larger for Korean consumers than for China consumers. Practical, theoretical implication and this paper’s limitations are also discussed.