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황금(Scutellaria baicalensis)의 열수 추출물이 병원성 세균에 미치는 항균활성
김은님,백종윤,김용현,한만덕 순천향대학교 기초과학연구소 2008 순천향자연과학연구 논문집 Vol.14 No.1
This study was investigated antibacterial activity of aqueous fractions from ScuteItaria baicalensis against various pathogenic bacteria. Extracts were obtained from the roots of 5. baicatensis which has shown selective antibactehal effects on various strains of bacteria. The aqueous extract of S. baicatensis was tested on 19 species of human pathogenic bacteria. The bacteria were cultured in nutrient broth, and YM broth then incubated aerobically at 37℃ for 18-24 hours. Antimicrobial activities tested by paper disc and radial diffusion assay methods. The aqueous extracts of 5. baicatensis inhibited the growth of most human pathogenic bacterial and showed 62.5㎎/㎖ of MIC values against StaphyIococcus aureus SG511 and 125㎎ /㎖ of MIC values against Staphytococcus aureus 285 and Staphylococcus aureus 503. These results suggest that S. baicaIensis extract can be used as an effective natural antibiotics.
신장에서 노화에 따른 Sirtuin1-NFE2-related Factor 2 Signaling의 변화
배명남 ( Myoung Nam Bae ),최민석 ( Min Seok Choi ),음상훈 ( Sang-hoon Eum ),김은님 ( Eun Nim Kim ),임지희 ( Ji Hee Lim ),김민영 ( Min Young Kim ),반태현 ( Tae Hyun Ban ),장인애 ( In-ae Jang ),윤혜은 ( Hye Eun Yoon ),박철휘 ( Cheol 대한내과학회 2017 대한내과학회지 Vol.92 No.1
Background/Aims: Renal aging-related changes are characterized by oxidative stress. SIRT1 regulates cellular conditions by activating Nrf2. The present study investigated the processes of renal changes by antioxidant enzymes and the relationship between SIRT1 and Nrf2. Methods: We used male 2-, 12-, and 24-month-old C57BL/6 mice. We measured renal function, histological changes, oxidative stress, and expression of SIRT1-Nrf2 signaling in the kidneys. Results: 24-month-old mice exhibited increased albuminuria and serum creatinine. Creatinine clearance was decreased in 24-month-old mice compared with 12-month-old mice. There were increases in mesangial volume and tubulointerstitial fibrosis in 24-month-old mice. Moreover, oxidative stress marker, 3-Nitrotyrosine, expression and apoptosis were increased in 24-month-old mice. The 24 h urinary 8-isoprostane and 8-hydroxy-deoxyguanosine excretion increased with aging. The levels of expression of SIRT1 and nuclear Nrf2 were decreased in 24-month-old mice. The antioxidant enzymes HO-1 and NQO-1 were down-regulated in 24-month-old mice. Another antioxidant enzyme, SOD2, was decreased in 24-month-old mice. Conclusions: Our results demonstrated that SIRT1 was down-regulated with aging, and this may be related to changes in the expression of target molecules including Nrf2. As a result, oxidative stress was induced. The pharmacological targeting of these signaling molecules may reduce the pathological changes associated with aging in the kidney. (Korean J Med 2017;92:53-61)