자궁경부의 원발성 악성 흑색종 1 예

김원규(Won Gue Kim),이인철(In Cheol Lee),허방(Bang Hur) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

Malignant melanoma is usually a neoplasm of the skin and mucous membranes which is relatively rare, comprising 1% of all cancers. In women, approximately 3% of malignant melanoma are located in the genitalia with the vast majority occuring in the vulva and very rarely on the ovary, uterus, and uterine cervix. Opinions about its histogenesis, diagnostic criteria and elective treatment are controversial, because of rare manifestation. We report a case of primary malignant melanoma of uterine cervix with a brief review of the literature.

침윤성 자궁 경부암에서 p16 단백의 변형

안선의(Sun Nie Ahn),김원규(Won Gue Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.4

Objective : Recently p16 gene has been found as a new factor for cervical carcinogenesis. The purpose of this study is to investigate the p16 protein alteration in invasive cervical cancers, and to find the correlation with the p53 protein overexpression, HPV infection and the clinicopathologic prognostic parameters, as well as to predict the prognosis by examining the influences of the p16 gene, p53 gene, HPV to the survival rate. Material & Methods : We examined 29 invasive cervical cancer patients who visited and operated in Obstetrics & Gynecology department of Kosin University Gospel Hospital from Jan. 1994 to Dec. 1995. We investigated clinicopathologic parameters and p16 protein alteration, p53 protein overexpression, HPV 16, 18 infection in these patients. p16 protein and p53 protein were examined by immunohistochemistry method and HPV was done by PCR method. The survival rate was examined by Kaplan-Meier method. Results : The rate of p16 protein alteration, p53 protein overexpression, HPV infection were respectively 31% (9/29), 72.4% (21/29), 80.6% (26/29), and all of these factors had no statistical correlations with the clinicopathologic parameters (p>0.05). Among the 21 positive cases for p53 protein overexpression, p16 protein alteration was positive in 6 (28.6%), negative in 15 (71.4%) cases and among the 8 negative cases for p53 overexpression, p16 showed positive in 3 (37.5%), negative in 5 (62.5%). Finally among the 26 positive cases of HPV infection, p16 alteration was positive in 9 (34.6%) and negative in 17 (65.4%) and all of the 3 HPV infection negative cases showed no p16 alteration. The p16 alteration had no significant correlation with the p53 overexpression and HPV infection. The total 5 years survival rate in 29 cases of invasive cervical cancer patients was 86.2%. In the negative group of p16 protein alteration the survival rate was 80% and the positive group was all alive. In the positive groups of p53 protein overexpression and HPV infection the survival rate were 80.9% and 84.6% respectively and the negative groups were all alive. And these factors had no significant correlation with the survival rates. Conclusion : This results indicate that p16 protein alteration had no correlation with clinicopathologic prognostic parameters and survival rates in invasive cervical cancer. In addition p16 protein alteration had no correlation with p53 protein overexpression and HPV infection respectively.

양성 난소 기형종에서 속발된 선세포암 1 예

서자영(Ja Young Seo),김원규(Won Gue Kim),김영옥(Young Ok Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

The mature cystic teratoma is the most common ovarian neoplasm arising in young women and comprises approximately 10-20% of all ovarian tumors. But malignant transformation is an uncommon complication in a mature cystic teratoma(dermoid cyst) of ovary, usually being reported in about 2% of cases. Among those rare tumors with malignant change in a mature cystic teratoma, 80% are squamous cell carcinoma, 7-8% are sarcomas of various types, 6-7% are adenocarcinoma, and the remainder include thyroid carcinomas, carcinoids, and melanomas, and choriocarcinomas, and mixed malignancies. We experienced a case of adenocarcinoma arising in mature cystic teratoma of the ovary and report this case with a brief review of literatures.

경계성 부난소종양

이태화 ( Tea Hwa Lee ),이천준 ( Chun June Lee ),김원규 ( Won Gue Kim ),김성한 ( Sung Han Kim ),정민정 ( Min Jung Jung ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10

Paraovarian cysts arise in the mesosalpinx, between the ovarian hilum and the fallopian tube. Clinical significance of paraovarian tumors is considerably less frequent than ovarian tumors, and malignant paraovarian lesions are exceedingly rare. Paraovarian carcinomas or borderline malignancy mostly occur in young women. Abdominal enlargement and pelvic pain are the usual complaints. Usually they have a capsule, are unilateral and are connected to the broad ligament. Little is known about the biological behavior of the paraovarian borderline malignancies, since these lesions are so rare. The appropriate therapy for this unusual lesion have not been fully defined. We had experienced a case of papillary serous adenocarcinoma of borderline malignancy and report this case with a brief review of literature.

자궁경부의 선양낭성암종

박혜은 ( Hye Eun Park ),이천준 ( Chun June Lee ),김원규 ( Won Gue Kim ),공은희 ( Eun Hee Kong ),김소희 ( So Hee Kim ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.6

성별이 다른 쌍둥이에서 다운증후군의

이태화 ( Tae Hwa Lee ),이천준 ( Chun June Lee ),김흥열 ( Heung Yeol Kim ),김원규 ( Won Gue Kim ),김성한 ( Sung Han Kim ) 대한주산의학회 2008 Perinatology Vol.19 No.2

Down syndrome is a chromosome related desease that shows mental retardation, growth retardation and many other signs such as defects in the face, hands and skin. Down syndrome is very uncommon in dizygotic twins, especially in twins with different sex. This twin`s chromosomal analysis shows both twins with trisomy 21, but the parents` chromosomal analysis is normal. A 30 year old infertile woman who became pregnant via ICSI(intracytoplasmic sperm injection) has shown dizygotic twins with different sex to have Down syndrome and therefore it is being reported along with simple documents.

크루켄버그 종양 32 예에 대한 분석

남영일(Young Il Nam),이병욱(Byung Wook Rhee),김원규(Won Gue Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

Objective : The Krukenberg tumor is a metastatic or primary malignant ovarian tumor of the signet-ring cell type. The incidence of this tumor is higher in Korea than in western, among relatively young age group with poor prognosis. We evaluated the clinical characteristics of the Krukenberg tumor (metastasized from stomach cancer) and the relationship between the survival and clinical characteristics (including treatment modalities) Methods : We analyzed 32 cases of the Krukenberg tumor metastasized from stomach cancer at the Department of Obstetrics and Gynecology, Kosin University Gospel Hospital. Results : Among the 32 cases of the Krukenberg tumor, the age distribution ranged from 22 to 58 years, and the mean age was 38.8 years. The most common chief complaint was lower abdominal pain(11 cases). The majority of the stomach cancer showed serosal invasion and was signet-ring cell type in histology. The mean survival was 20 months. In patients with ascites(22 cases), the mean survival was 16 months in contrast to 25 months in ascites-free patients(10 cases). In the chemotherpy group, the mean survival was 23 months in contrast to 16 months in chemotherpy-free group. Also, longer mean survival(25months) was shown in cases with optimal surgery group than non-optimal surgery group. Conclusions : The survival of krukenberg tumor was shown to be related to the surigcal resectability and chemotherpy modalities.

10년간 임신성 융모성질환의 임상적 고찰

김원규,박은동,주은희,유건상 대한부인종양 콜포스코피학회 1996 Journal of Gynecologic Oncology Vol.7 No.2

For the clinical analysis and evaluation on the patients with gestational trophoblastic disease(GTD), a study was done retrospectively on 114 patients with GTD(60 in Hydatidiform mole, 10 in invasive mole, 44 in choriocarcinoma) treated from Jan. 1, 1985 to Dec. 31, 1994 at the Department of Obstetrics and Gynecology, Kosin Medical College, Pusan, Korea. We obtained the following results ; The incidence of GTD was 1 per 73 deliveries in H. mole, 1 per 437 deliveries in invasive mole, and 1 per 99 deliveries in choriocarcinoma. The most prevalent age was 21-40 groups. Abnormal vaginal bleeding was a main symptom and sign. 30.6% of H. mole was managed by dilatation and curettage. 90.0% of invasive mole and 51.4% of choriocarcinoma were managed by surgical treatment and chemotherapy. The overall remissinon rate of choriocarcinoma was 71.4%(100.0% in stage I, 66.7% in stage II, 54.5% in stage III, 50.0% in stage IV).

양성 난소기형종에서 속발된 선-편평상피세포암의 1례

김원규 고신대학교 의학부 1993 高神大學校 醫學部 論文集 Vol.9 No.2

The dermoid cyst is the most common ovarian germ cell neoplasm and comprises approximately 10 % of all ovarian tumors. Primary malignant degeneration of a benign cystic teratoma of the ovary is not frequent, but does occur. This sequence can be assumed when the unquestionably malignant lesion occurs in a definitely localized area of a dermoid that is otherwise entirely benign. The incidence of primary malignant degeneration of a benign cystic teratoma of the ovary is variously reported to be from 0.8 % to 8 % . This great divergence can be partially explained by the inclusion of small series of cases, for more extensive ones. report the incidence to be from 0.8% to 3.8%. Any types of malignant degeneration or a combination of malignancies can arising in benign cystic teratomas of the ovary. Among those rare tumors with malignant change in a benign dermoid, 80-88 % are squamous. 6- 7 % are adenocarcinoma, and 7 - 8 % are sarcomas of various types, and the remainder include thyroid carcinomas, carcinoids and melanomas, and choriocarcinomas, and mixed malignancies (ex : adenosquamous and epidermo-sarcoma) We experienced a case of adenosquarmous cell carcinoma arising in benign cystic teratoma of It ovary in 56 years old woman, so we report this case with a brief review of literatures.

35세 이하 여성에서의 침윤성 자궁경부암

김원규,박은동,주은희 대한부인종양 콜포스코피학회 1995 Journal of Gynecologic Oncology Vol.6 No.1

The incidence in women less than 35 years of age is increasing despite an overall decrease in newly diagnosed invasive cervical cancer among all age groups. However the influence of young age on prognosis remains controversial. So 163 patients of invasive cervical cancer in women aged 35 or less treated from Jan. 1, 1984 to Dec. 31. 1993 at the Department of Obstetrics and Gynecology, Kosin Medical College, Pusan, Korea, were studied retrospectively. We obtained the following results; The 5 - year survival rates by clinical stage were 88.7Y% in stage I b, 71.5% in stage IIa, 31.2% in stage IIb and O% in stage III or above. The lymph node metastasis rates by stage in RAH group, were 21.3% in stage I b and 31.8% in stage IIa. The lymph node metastasis rates by lesion size in RAH group, were 19.2% in 2cm below, 20.7% in 2-4cm and 40.0% in 4cm above. The 5 - year survival rates in RAH group were 74,9% in lymph node positive group and 89.0% in lymph node negative group. The recurrence rates by clinical stage were 0% in stage Ia, 20.6% in stage I b, 22.2% in stage IIa, 50.0% in stage Ilb and 90.9% in stage III or above.