http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이은혜,백수연,김광연,이슬기,김상찬,이형식,김영우,Lee, Eun Hye,Baek, Su Youn,Kim, Kwang-Youn,Lee, Seul-Gi,Kim, Sang Chan,Lee, Hyeong Sik,Kim, Young Woo 대한한의학방제학회 2016 大韓韓醫學方劑學會誌 Vol.24 No.3
Objectives : Rheum undulatum Linne and Glycyrriza uralensis Fischer are widely used herbal medicine. In this study, anti-oxidant and liver protective effects of R. undunlatum extract (RUE) and G. uralensis extract (GUE) were investigated in HepG2 cells, respectively. Oxidative stress and liver fibrosis were induced by arachidonic acid (AA) and iron, and CCl<sub>4</sub>.Methods : MTT assay was assessed for cell viability, and immunoblotting analysis was performed to detect expression of apoptosis related proteins. In addition, reactive oxygen species (ROS) and mitochondrial dysfunction were measured. In vivo, BALB/c mouse were orally administrated with the aqueous extract of 10 mg/kg RUE and 100 mg/kg GUE for 3 days and then, injected with CCl<sub>4</sub> 0.5 ml/kg body weight to induce acute liver damage. Serum ALT level was measured, and histological change was observed in Harris's hematoxylin and eosin stainResults : RUE and GUE pre-treatment increased relative cell viability in concentration dependent manner and altered the expression levels of apoptosis-related proteins such as procaspase 3, PARP and Bcl-xL. RUE and GUE also inhibited the mitochondrial dysfunction and excessive reactive oxygen species (ROS) production induced by AA and iron. In addition, RUE and GUE activated liver kinase B1 (LKB1), by increasing phosphorylation. Moreover, RUE and GUE treatment decreased liver injuries induced by CCl<sub>4</sub>, as evidenced by decreases in histological liver damage as well as serum alanine amino transferase (ALT) level.Conclusions : These data suggest that RUE and GUE has anti-oxidant and liver protective effects against AA and iron-induced oxidative stress and CCl<sub>4</sub>-induced liver injury.
윤호중,김영우,손호영,차봉연,홍관수,홍대식 대한내분비학회 1986 Endocrinology and metabolism Vol.1 No.1
Excessive TSH secretion from pituitary tumor is one of the least common cause of thehyperthyroidism. Its clinical characteristics are distinguished from hyperthyroidism due to Graves' disease, toxic nodular goiter, subacute or Hashimoto's thyroiditis and subacute lymphocytic thyroiditis by the elevated serum TSH level.We experienced a case of 35-year old female with hyperthyroidism due to TSH-secreting pituitary ademoma. Her thyroid Function studies showed the elevated serum T3, T4 and TSH. Skull X-ray and brain CT revealed a enlarged sellae turcica and pituitary tumor with suprasellae extension. Basal serum cortisol level was lower than normal value. And combined pituitary stimulation test showed the normal response of LH, FSH and PRL, but the response of serum cortisol, growth hormone and TSH were blunted. Serum TSH responses were blunted to TRH stimulation test. The elevated serum TSH level was not suppressed to 8 mg dexamethasone suppression test. So we present thes case with a review of literatures.