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RISS 인기검색어
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- 저자 : 김영설(Young Seal Kim) (검색결과 2 건)
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손현석(Hyun Suck Son),윤현구(Hyun Koo Yoon),김성운(Sung Woon Kim),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seal Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi) 대한내과학회 1991 대한내과학회지 Vol.40 No.5
N/A Diabetes mellitus can be divided into insulin-dependent (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) by NDDG criteria largely based on clinical features. Recently the development of a radioimmunoassay for human C-peptide and of ICSA assay have provided insight into the pathogenesis of diabetes mellitus. We observed the characteristics of 105 diabetics under 40 years of age and classified these patients by their clinical features, ICSA and 24 hour urine C-peptide. The results were as follows: 1) Diabetic ketoacidosis developed in R patients (3%). of these, patients belonged to the 1st decade (8 patients), which had the highest incidence of diabetic ketoacidosis. 2) Considering of family history and obesity, the cases with typical NIDDM, which had family history and were obese, were between 4% and 29%. The cases with typical IDDM, which had no family history and were not obese, were between 45%, and 60%. 3) Considering family history, obesity and insulin secretory capacity, the cases with typical NIDDM, which had family history and normal or increased insulin secretory capacity and were obese, were 15%. The cases with typical IDDM, which had not family history and decreased insulin secretory capacity and were not obese, were 14. 4) In ICSA assay, 12.5% of the patients were positive. All these patients had family history, various obesity and increased insulin secretory capacity. In conclusion, in Korean diabetics between 15 and 40 years of age, 15 percent of the patients were considered typical NIDDM and 14 percent were considered typical IDDM, The remaining patients could not be classified accurately and turther detailed study were needed.
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흰쥐 성장호르몬 및 베타 - 엔돌핀 분비에 미치는 심방성 나트리움 이뇨인자의 영향
김봉회(Bong Hoi Kim),김영설(Young Seal Kim),최영길(Young Kil Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A The presence and localization of ANF in the rat brain were demonstrated and the possible role of ANF as neuromodulator was suggested. Previous studies have revealed that the ANF suppresses the GH and IR-β-endorphin releases from cultured pituitary cell of rat. To confirm the action of ANF on pituitary hormone secretion we studied the effect of an intravenous administration of ANF on plasma GH and IR-β-endorphin levels in both anesthetized and conscious freely moving rats. Male wistar rats weighing 300-400 g were prepared with an indwelling right atrial cannulae and use for studies 4 days later, Plasma GH and IR-β-endorphin concentration were determined respectively by RIA with double antibody methods. 1. Following examination were performed and results were obtained in pentobarbital anesthetized rats. 1) Administration of ANF decreased plasma GH levels at dose of 1, 5, and 10 ㎍/kg B.W. 2) GRF(1 ㎍/kg B.W.) increased plasma GH levels, but prior administration of ANF at dose of 5 and 10 ㎍/kg B.W. reduced GH response to GRF. 3) Administration of ANF decreased plasma IR-β-endorphin levels at dose of 10 ㎍/kg B,W. 4) oCRF(1 ㎍/kg B.W.) increased plasma IR-β-endorphin levels, but prior administration of ANF at dose of 10 ㎍/kg B.W. blocked effect of oCRF on IR-β-endorphin secretion. 2. Administration of ANF into conscious rats abolished expected GH peak but another peak appeared during trough phase of control. These results suggest that ANF is probably inolved in regulatory mechanisms of GH and β-endorphin secretion.
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