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김영건(Young Kun Kim),이복희(Bok Hee Lee),정선묵(Seon Muk Jeong),정현용(Hyun Yong Jeong),김연길(Yun Keel Kim) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2
N/A A clinical analysis was performed in 408 patients with peptic ulcer among the various upper gastrointestinal diseases(2108 cases), who were diagnosed gastroduodenoscope at the endoscopic room of Chung Nam National University Hospital during period from January 1980 to August 1984. The results were as',follows: I) Of the total 2108 cases, the main diseases were gastritis(28.5%), gastric cancer(195 benign gastric ulcer(11.5%), etc, in order of frequency. 2) The symptoms of peptic ulcer were epigastric pain or discomfort(83.5%), melena or hematemesis(39.4%), indigestion, etc. 3) Of the 408 cases with peptic ulcer, 239 cases(58%) were gastric ulcer, 144 cases(35%) were duodenal ulcer and others were gastroduodenal combined ulcer. 4) Of the 408 cases with peptic ulcer, 339 cases (83.1%) were male and 68 cases(16.9%) were female. The male to female ratio was 5:1 and the highest number was in the 3th decade (26.2%). Gastric ulcer was distributed most commonly in the 6th decade(32.6%) and had high male to female ratio(6:1). Duodenal ulcer was been relatively younger age of the 4th decade(25%) and 5th decade(24%), had low male to female ratio(3.5:1). 5) In the annual distr ibution of peptic ulcer from to 1984, gastric ulcer was 29.9%, 69.8%, 62.0%, 54.1%, 51.1%, respectively and duodenal ulcer was 28.6%, 27.9%, 33.8%, 37.8% and 40%. And there was evidence of increasing tendency in duodenal ulcer. 6) The most common prevalent site of gastric ulcer in all age was gastric angle. The more old age, the upper stomach was involved. The most favorable site of duodenal ulcer was bulb (81.2%) and pyloric canal(17.4%). 7) The most frequent size of gastric ulcer(34.6%) was from l.0 cm to 1.9 cm. And that of duodenal ulcer was from pinhead to 0. 4cm(50.2%). 8) Among the 408 cases who has been confirmed peptic ulcer by gastroscopy, 219 cases have been taken UGI examination concomitantly. The concordance rate of gastric ulcer, duodenal ulcer svas 70%and 76.9%, respectively.
김성걸(Seong Gul Kim),최지영(Jee Young Choi),임의혁(Euyi Hyeog Im),김진희(Jin Hee Kim),육은주(Eun Ju Yook),김병호(Byeong Ho Kim),성자원(Ja Won Sung),김남재(Nam Jae Kim),정현용(Hyun Yong Jeong),이헌영(Heon Young Lee),김영건(Young Kun 대한소화기학회 1995 대한소화기학회지 Vol.27 No.2
Primary small intestinal lymphomas are a hetorogenous group of tumors ortginating from the lymphoid cells of the mucosa and submucosa of the small bowel. The ileum and jejunum are most frequently affected, whereas duodenal involvement is less common. There is a himodal age distribution with peak incidences below the age of 10 and in the fifth and sixth decados, with a slight male prodominance. And it is very difficult to diagnose until the dovelopment of any complications such as obstruction, perforation ancl hemorrahage because of the insidious onset of disense and relative inaccuracy of the diagnostic tools as in all the small bowel tumor. Optimal treatment choices for lymphoma remain controversial. Surgical resection, in many cases, is considered the first line of defense. Primary malignant lymphoma of the small intestine has poorer prognosis due to the delay of the diagnosis than any other extra-intestinal malignancy, but has the better prognosis than any other small intestinal malignancy. The histologic type, the extent of the intestinal disease, and the prosence or absence of extraintestinal involvement are the important factors in prognosis. Patients with resectable disease typically have a 40/r, to 507r, S-year survival. Recently the authers diagnosed the primary small intestinal lymphoma associated with a large amount of bleeding confirmed by intraoperative biopsy. So we report this case with the review ot literatures. (Korean J Gastroenterol 1995;27:251-255)
육은주(Eun Ju Yook),전준식(Joon Sik Jeon),김성걸(Seong Gul Kim),김진희(Jin Hee Kim),김남재(Nam Jae Kim),정현용(Hyun Yong Jeong),이헌영(Houn Young Lee),김영건(Young Kun Kim),김응중(Eung Jung Kim),이영(Young Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
We report two cases of Morgagnis hernia comprising the protrusion of omentum alone. The treated patients were 65- and 64-year old women. They were referred to our hospital due to epigastric discomfort, or dypnea accompanied by an abnormal shadow in right cardiophrenic angle on chest roentgenogram. Surgery through an abdominal approach was preferred and the post- operative course was benign. (Korean J Gastroenterol 1996;28: 148 150)
Ranitidine 의 소화성궤양치료효과에 대한 임상적연구
김영건(Young Kun Kim),윤성열(Sung Yeul Yoon),정현용(Hyeon Yong Jeong),정선묵(Seon Muk Jeong) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.2
N/A This study was performed to assess the clinical therapeutic effectiveness of anti-histamine agent, ranitidine. The drug was given in the dose of 150mg twice a day to 12 cases of gastric ulcer and 11 cases of duodenal ulcer. Initial diagnosis and follow up observation after 4 weeks, 6 weeks and 8 weeks of treatment were made by the upper G-I endoscopy. The results observed are as followings. 1) The male to female ratio of the subject was about 20:3 and the most prevalent age group was the sixth decade of the life in both the gastric and duodenal ulcer groups. 2) The location of gastric ulcer were 7 cases in body and 5 cases in angle of the stomach and duodenal ulcer were 7 cases in bulb and 4 cases in pyloric area. 3) As for the subjective symptoms, epigastric pain, heart-burning sensation, hunger pain, abdominal discomfort, dyspepsia were experienced, and were relieved after 1 week of treatment in 60 80%, and were completely relieved after 4 weeks of treatment in all cases respecti vely. 4) The cumulative rates of complete healing of the gastric ulcer (12 cases) were 75% (9 cases) after 4 week, 92% (11 cases) after 6weeks, 100%(12 cases) after 8 weeks of treatment, and those of the duodenal ulcer (11 cases) were 91%(10 cases) after 4 weeks, 100%(11 cases) after 6 weeks of treatment. 5) The untoward side effect were not found. In conclusion ranitidine appears to be effective and safe for the treatment of patients with peptic ulcer disease.
간경변증 환자에서 간신티그램을 이용한 Propranolol 투여 전후의 간혈류 변화
김병호(Byeong Ho Kim),서광석(Kwang Suk Seo),김진희(Jin Hee Kim),김성걸(Seong Gul Kim),육은주(Eun Ju Yook),임의혁(Euyi Hyeog Im),성자원(Ja Won Sung),이강욱(Gang Wook Yi),정현용(Hyun Yong Jeong),이헌영(Heon Young Lee),김영건(Young Kun 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1
N/A Esophageal varix bleeding due to portal hypertension in liver cirrhotics is very emergency state and difficult for management. In spite of many kinds of treatment in esophageal varix bleeding such as medical and surgical methods, but cant be expected of good results. Lebrec report that propranolol is significantly decreased portal venous pressure in 1980. This study analyzed the portal hemodynamics by liver scintigraphy of 38 patients with liver cirrhosis who were proven to have esophageal varices and 10 norrnal subjects. The 19 cirrhotics had taken liver scintigraphy before and after propranolol medication. There were significant difference in HAI(Hepatic Arterial Index) between cirrhotics and normal subjects(64.7k16.5/ vs 31.9+8.3%, p<0.001). There were no significant difference in HAI according to the Childs classification, the type of variceal morphology and the presence of ascites, but the HAI in Child B(68.1%) and C(63.4%) groups were higher than that in Child A group(55.5%). The heart rate decreased significantly after propranolol ( 7.6No./min, p<0.001) and the HAI increased significantly after propranolol (+8.0%, p<0.05). It should be suggested that propranolol is effective in decreasing the portal hypertension by decreasing the portal blood flow. There were no serious complication of propranolol. In conclusion, these results suggest that propranolol could be a potentially useful and safe agent in management and prevention of variceal bleeding by decreasing the portal hypertension and the liver scintigraphy with Tc tin colloid is reasonably a accurate, simple, safe, and rapid method, therefore can be considered suitable for use in the assecement of liver hemodynamics.(Korean J Gastroentero11994; 26: 119-126)
위선종과 위암에서 면역조직화학적 염색을 이용한 p53 단백 발현율의 비교
김진희(Jin Hee Kim),서광식(Kwang Sik Seo),김성걸(Seong Gul Kim),임의혁(Euyi Hyeog Im),육은주(Eun Ju Yook),정현용(Hyun Yong Jeong),이헌영(Houn Young Lee),김영건(Young Kun Kim),이충식(Choong Sik Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5
N/A Backgrounds: The mutation of p53 gene and p53 protein accumulation is discovered in dysplasia of stomach and gastric cancer. We compared p53 protein expression rate with gastric adenoma and gastric cancer using the immunohistochemical stain and tried to know the correlation of the malig- nant potential of gastric adenoma with p53 protein expression. Methods: We obtained 52 tissues from 22 gastric cancers and 30 gastric adenomas. Accumulation of p53 protein was detected by immunohistochemistry using Anti-Human p53 monoclonal antibody(Pab 1801; Pharmingen). Results: p53 immunoreactivity was detected in 33.3% of gastric adenomas and in 59.l% of gastric cancers. But, threre was no significant difference between two groups(p=0.065). The rate of p53 expression according to various stages, differentiations, cell types in gastric cancers was not significantly different. Also, p53 expression rate according to cell types, size in gastric adenomas showed no significant difference. Conclusions: We suggest that mutation of the p53 gene is an early event in stomach tumorigenesis. But there is to be required more research about the correlation of the malignant potential of gastric adenoma with p53 protein expression. (Korean J Gastroenterol 1995;27: 509 - 516)
소화기암 세포주에 대한 Interferon 의 항암제 세포독성 증강 효과
김성철(Sung Chul Kim),길준영(Jun Young Kil),전의건(Eui Gun Chun),윤환중(Hwan Jung Yun),조덕연(Deog Yeon Jo),김삼용(Sam Yong Kim),김영건(Young Kun Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.5
N/A Background: 1nterferons (IFN) have antiproliferative activity and immune moduiatory function. Interferons and cytotoxic drugs have different mechanism of action on cancer cells. To investigate the interaction of interferons with cytotoxic drugs, we treated human gastrointestinal cancer cells with combinations of anti- cancer drugs and interferons. Methods: Using the colorimetric [3-(4, 5-dimethlyth- iazo1-2-yl)-2, 5-diphenyltetraxolium bromide] (MTT) assay, we evaluated the chemosensitivity of anticancer drugs (5-fluorouracil, adriamycin), and the inhibitory effects of alpha interferon and gamma interferon, and the cytotoxic effects of the combination of interferons and anticancer drugs against the human gastric cancer cell line SNU-5 and the colon cancer cell line SNU-C. Results : Both 5-FU and adriamycin produced dosedependent inhibition of cancer cell growth; the alpha interferon and the gamma interferon had 12% and 18% inhibitory effects against SNU-5 cells respectively, and they showed 29% and 30% inhibitory effects against SNU-C1 cells respectively. Cytotoxicity of anticancer drugs was markedly augmented by the addition of alpha or gamma interferons. The II4 values of 5-FU and adriamycin decreased to 1/ 37 and 1/33, respectively, when alpha interferon was added to these drugs, and ID50 values of 5-FU and adriamycin decreased to 1/7 and 1/5.4, respectively, when the gamma interferon was added. Conclusions: The results indicate that interferons, when used concomitantly with the cytotoxic drug 5-FU or adriamycin, can augment the cytotoxicity of the latter drugs. A clinical trial incorporating interferons with anticancer drugs in gastrointestinal malignancies should be warranted.
충청지방의 A 형 간염 바이러스 항체에 관한 역학적 조사
이재익(Jae Ik Lee),김진용(Jin Yong Kim),김승태(Seung Tae Kim),윤성열(Sung Yeul Yoo),정선묵(Sun Mook Chung),김영건(Young Kun Kim),이복희(Bok Hee Lee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.2
N/A Anti-HA was examincd in a total of 543 cases by radioimmunoassay techniqne, including 358 pediatric patients, and 185 healthy adults without history of liver disease. The results obtained are as follows In child group, the positive rate of Anti-HA was 97.8% uncer 1month old, and tend to be decreased with a e. The nositive rate of Anti-HA;:as C, in 8 to 0 r,-o..ths old,;:r.d then the positive rare wae slowly increased with age. After 9 years old, the rate was increased rapidly 68.8% in 9-10 years, 81.2% in 11 2 years and 84.6% in 13-15 years. In adult group, the positive rate of Anti-HA was 94.6%, in 16-20 years old, 93.0%% 21-30 years, 97.2% in 88.2% 41-50 years, 93.8% in 51-60 years and 88.2% in 61-80 years.