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문주란 추출물의 HL-60 백혈병 세포 Apoptosis 유도 효과
현재희,김엘비라,강정일,김상철,유은숙,강희경,Hyun, Jae-Hee,Kim, El-Vi-Ra,Kang, Jung-Il,Kim, Sang-Cheol,Yoo, Eun-Sook,Kang, Hee-Kyoung 대한약학회 2008 약학회지 Vol.52 No.1
The present study investigated the antiproliferative effects of Crnum asiaticum var. japonicum against HL-60 human leukemia cells. The 80% MeOH extract or several solvent fractions from the C. asiaticum inhibited the growth of HL-60 cells, whereas the growth of HEL-299 cells, human embryonic lung fibroblast, was scarcely inhibited. When the HL-60 cells were treated with the $CHCl_3$ fraction, the BuOH fraction, the EtOAc fraction and the $H_2O$ fraction, DNA ladder, chromatin condensation and increase of sub-G1 hypodiploid cells were observed. Furthermore, the $CHCl_3$ fraction and the BuOH fraction reduced Bc1-2 mRNA level, whereas Bax mRNA level was increased. These results suggest that the inhibitory effect of C. asiaticum on the growth of the HL-60 cell might be mediated through the induction of apoptosis via the down-regulation of Bc1-2. Taken together, components of C. asiaticum might have a therapeutic potential for the treatment of human leukemia.
광원을 내장한 펜의 출력광과 광 도파로의 광 결합을 이용하는 터치 패널 장치의 내부 광 결합 구조 설계
박대서,김대종,오범환,박세근,이일항,이승걸,Park, Dae-Seo,Kim, Dae-Jong,O, Beom-Hoan,Park, Se-Geun,Lee, El-Hang,Lee, Seung-Gol 한국광학회 2009 한국광학회지 Vol.20 No.2
본 연구에서는 광원을 내장하고 있는 포인팅 펜(pointing pen)의 출력광과 광 도파로 배열 사이의 광 결합을 이용하여 펜의 접촉여부와 접촉 위치를 검출하는 광학식 터치 패널 장치를 제안한다. 펜의 출력광과 광 도파로 배열 간의 광 결합을 최대화하고, 동시에 특정 광 도파로로 결합된 광속이 적은 손실로 전파할 수 있도록 하기 위해 광 도파로의 교차점 마다 부가적인 피라미드 구조를 삽입하였다. 광 도파로 단면의 크기가 $50{\times}50{\mu}m^2$인 경우 광선 추적법을 통해 결정된 피라미드의 최적 구조는 밑변의 폭, 높이, 경사각이 각각 $50{\mu}m$, $22.5{\mu}m$, $42^{\circ}$이었다. 이때 광 결합 효율은 97.8%이었으며, 전파손실은 평균적으로 0.3 dB/mm이었다. 그리고 펜의 기울어짐에 대한 허용 각도는 ${\pm}12^{\circ}$임을 확인하였다. In this paper, an optical touch panel device is newly proposed, with operating principle based on the optical coupling between a pointing pen having a built-in light source and perpendicularly crossed optical waveguide arrays. In order to enable an external light to couple into a waveguide core, the auxiliary pyramidal structures are introduced into all intersecting points located periodically along optical waveguides. The shape is optimized for minimizing the unwanted propagation loss due to the same structure by a ray tracing method. For the optical waveguide with the size of $50{\times}50{\mu}m^2$, the bottom width, height, and slope angle of the optimized pyramidal structure are $50{\mu}m$, $22.5{\mu}m$, and $42^{\circ}$, respectively. The optical coupling efficiency of about 97.8% and the average propagation loss of 0.3 dB/mm were achieved for the optimized touch panel. Finally, it is found from the tolerance analysis that tilting of the pen up to ${\pm}12^{\circ}$ can be allowed.
김지룡(Ji Ryong Kim),이예원(Ye Won Lee),김엘(El Kim),남성일(Sung Il Nam) 대한두개저학회 2017 대한두개저학회지 Vol.12 No.2
To completely remove the petrous bone cholesteatoma (PBC) have been a surgical challenge for many years because of tight adhesion or invasion of the matrix into surrounding vital structures such as the labyrinth, middle and posterior cranial fossa dura, internal carotid artery, facial nerve canal or jugular bulb. The main factors influencing the surgical approach to choose are the inaccessible nature of the petrous bone, the extent of disease, the degree of facial nerve function, and the need for the prevention of cerebrospinal fluid leaks and the recurrence of the lesion. We present the case of a 55- year-old male presenting with right-sided facial palsy PBC treated by transotic approach. Facial palsy in the operated ear improved after surgery. We conclude that transotic approach is a safe and effective approach to the supralabyrinthine PBC region.
비중격 피판 거상을 동반한 경접형동 접근법 시행 후 후각 기능의 단기 회복 양상
김지룡(Ji Ryong Kim),김엘(El Kim),정종인(Jong In Jeong) 대한두개저학회 2017 대한두개저학회지 Vol.12 No.2
Background: The cases of endoscopic skull base surgery applied in more aggressive lesions have increased recently, raising interests about nasoseptal flap (NSF) for reconstruction. However, transient or permanent olfactory dysfunction may occur after NSF elevation, it have great influence on the quality of life of the patient. The aim of this study was to identify proper intervention time by comparing the recovery patterns of olfactory function after NSF elevation with conventional trans-septal approach. Methods: All subject were administered self-reporting olfaction score (Visual Analogue Scale [VAS], 0-10) and the threshold, discrimination, and identification (TDI) score of Korean Version of Sniffin Stick Test II (KVSS II) preoperatively. The trans-sphenoidal approach (TSA) was performed with conventional trans-septal approach or NSF elevation. VAS and TDI were followed-up by 12weeks after surgery. Results: Fifteen patients who underwent TSA were enrolled. Baseline VAS and TDI score were 9.2 and 28.3 in TSA group, and 7.7 and 24.6 in NSF elevation group. VAS of trans-septal approach group was recovered to the preoperative level from 8weeks after surgery, whereas NSF elevation group was 12weeks. TDI scores of trans-septal approach group were 12.1, 25.4, and 24.8 at 4, 8, and 12 weeks after surgery, whereas NSF elevation group were 10.6, 19.7, and 22.1. Conclusions: After TSA with NSF elevation, olfactory function is more gradually recovered than conventional trans-septal approach, and the intervention about permanent olfactory dysfunction may need to be considered for the poorly-improved olfactory dysfunction until 8weeks after surgery.