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고효율 항생제 감수성 검사를 위한 미세유체소자 내 선형적 항생제 농도구배 형성
김승규(Seunggyu Kim),이석훈(Seokhun Lee),전성윤(Jessie S. Jeon) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11
To determine the most effective antimicrobial treatments of infectious pathogen, high-throughput antibiotic susceptibility test (AST) is critically required. However, the conventional AST requires at least 16 hours to reach the minimum observable population. Therefore, we developed a microfluidic system that allows maintenance of linear antibiotic concentration and measurement of local bacterial density. Based on the Stokes-Einstein equation, the flow rate in the microchannel was optimized so that linearization was achieved within 15 minutes, taking into account the diffusion coefficient of each antibiotic in the agar gel. As a result, the minimum inhibitory concentration (MIC) of each antibiotic against P. aeruginosa could be immediately determined 6 hours after treatment of the linear antibiotic concentration. In conclusion, our system proved the efficacy of a high-throughput AST platform through MIC comparison with Clinical and Laboratory Standards Institute (CLSI) range of antibiotics.
이공계 대학생이 참여하는 청소년 교육용 과학관 전시 콘텐츠 개발
김승규(Kim, Seunggyu),한현택(Han, Hyeontaek),박종래(Park, Jongrae) 한국공학교육학회 2021 공학교육연구 Vol.24 No.3
The purpose of this study is for science and engineering students to experience social contribution through voluntary projects. The method of research is to create and introduce the exhibits and its exhibition commentary of Science Museum for local youth. The exhibition commentary is a project that stimulates student‘s interests in science and technology by providing scientific knowledge and research information. Producing exhibits is a project that discovers local technologies as well as introduces its history, technology, and scientific principles to young students. Two projects confirmed the positive effects of creating opportunities for science and engineering students to contribute to society and expanding scientific content, and showed implications for engineering education.
튜머로이드-혈관신생 상호작용의 가시화를 위한 개방형 구조 미세유체 칩 개발
김승규(Seunggyu Kim),김지원(Jiwon Kim),박준하(Joonha Park),오상윤(Sangyoon Oh),신현정(Jennifer H. Shin),전성윤(Jessie S. Jeon) 한국가시화정보학회 2020 한국가시화정보학회지 Vol.18 No.3
Cancer cells secrete angiogenic factors, and nearby vasculatures make new blood vessels essential for cancer development and metastasis in response to these soluble factors. Many efforts have been made to elucidate cancer-endothelial cell interactions in vitro. However, not much is known due to the lack of a suitable co-culture platform. Here, we introduce a 3D printing-based microfluidic system that mimics the in vivo-like cancer-endothelial cell interactions. The tumoroids and endothelial cells are co-cultured, physically separated by porous fibrin gel, allowing communication between two cell types through soluble factors. Using this microfluidic system, we were able to visualize new vessel formation induced by tumoroids of different origins, including liver, breast, and ovary. We confirmed that the ovarian tumoroids most induced angiogenesis while the other two cancer types suppressed it. Utilization of the proposed co-culture platform will help the researchers unveil the underlying mechanisms of the dynamic interplay between tumor and angiogenesis.