쇠무릎(Achyranthes japonica Nakai)으로부터 Ecdysteroid 생합성에 관련된 유전자의 분리

김소미,김대운,채현병,조문제,류기증,부경환,진성범,이도승 한국농화학회 2001 Applied Biological Chemistry (Appl Biol Chem) Vol.44 No.3

In order to isolate genes involved in ecdysteroids biosynthesis in plants, total RNA was isolated from Achyranthes japonica Nakai, and RT-PCR was performed using degenerate primers selected based on the results of multi-alignment of four cytochrome P450 genes from plants and a putative ecdysone 20-hydroxylase gene from an insect. Fourteen partial cDNA clones showing unique base sequences were obtained, out of which six showed homologies at the levels of nucleotide and amino acid sequences to the other cytochrome P450 genes known to be involved in the ecdysteroid biosynthesis. Of the six clones, four showed relatively high homologies to a putative ecdysone 20-hydroxylase gene isolated from an insect.

중국기업의 대 한국 투자 특성

김소미 서울大學校 社會科學大學 地理學科 2008 地理學論叢 Vol.52 No.-

The Development of China’s Venture Capital Industry and the Characteristics of its Capital Spatial Configuration

김소미 한국경제지리학회 2017 한국경제지리학회지 Vol.20 No.4

This paper examines the development process of China’s venture capital industry and the characteristics of its capital spatial configuration. The results reveal that the development of China’s venture capital industry has its unique modality, which varies greatly from existing studies, namely, the desynchronized paces of industry development as well as the regional real capital supply and demand trend. More detailed observation shows the Chinese venture capital’s spatial configuration has three main characteristics: first, the separation of the registered location and the actual location of business operation; second, the division and spatial configuration of the venture fund’s capital circulation. To find the relevant factors related to the above phenomena, a correlation analysis was conducted between both market factors and non-market factors with the above capital spatial configuration. The analysis confirmed that besides the market factors, local legislative condition also presents a high correlation with the phenomena.

혈액투석 환자에서의 수혈 전파성 감염으로 오인된 B형 간염 바이러스 잠재감염 의심 증례

김소미,김선형 대한수혈학회 2021 大韓輸血學會誌 Vol.32 No.1

A 73-year-old male patient undergoing hemodialysis showed an abnormal liver function test after the transfusion of two units of red blood cell (RBC). The results of the pre-transfusion test were negative HBsAg and positive anti-HBs. On the other hand, the results of the post-transfusion test were positive HBsAg and negative anti-HBs. The other test results were positive HBeAg, positive HBV DNA, and positive anti-HBc IgG. It was reported as a blood transfusion reaction in doubt of a transfusion-transmitted hepatitis B virus (HBV) infection. An examination of the blood information management system data, health insurance data, medical records, and test of storage samples showed that it was not a blood transfusion reaction. It was believed to be an occult HBV infection in an immunosuppressive patient receiving hemodialysis. Hemodialysis patients have a high prevalence of hepatitis B and C, and are classified as a risk group of occult infections. This raises the need for HBV vaccination in dialysis patients. Virus infections can be activated in dialysis patients due to the patient's immune system and other causes. If a blood transfusion is performed during this period, attention is needed because it can be mistaken for viral transmission from blood products. (Korean J Blood Transfus 2021;32:49-54)

Simple Method to Estimate Daily Sodium Intake in Peritoneal Dialysis Patients

김소미,이은경,조종태,강기수,송현주,강민숙,이은주,한수민,김순배 한국정맥경장영양학회 2016 한국정맥경장영양학회 학술대회집 Vol.2016 No.-

Background: Restriction of dietary sodium intake for peritoneal dialysis (PD) patients is recommended, but there is limited information on the measurement and monitoring of sodium intake. We have developed a simple method to estimate daily sodium intake during the measurement of dialysis adequacy in PD patients. Methods: A total of 83 PD patients from the Asan Medical Center were enrolled into the study. The patients were divided into two groups based on residual renal function (RRF). We measured total sodium removal and estimated daily sodium intake using dietary recall for 1 day, during the assessment of dialysis adequacy. Results: There were 39 patients in the RRF(-) group and 44 in the RRF(+) group. In both groups, and all patients, there were significant positive correlations between sodium intake and total sodium removal: RRF(-) group, r = 0.598; RRF(+) group, r = 0.577; total patients, r = 0.595. There were linear relationships between dietary sodium intake and total sodium removal in both groups: RRF(-) group, sodium intake (mg/d) = 19.28 × peritoneal sodium removal (mEq/d) + 211; RRF(+) group, sodium intake (mg/d) = 15.40 × total sodium removal (mEq/d) + 609. All PD patients, sodium intake (mg/d) = 15.64 × total sodium removal (mEq/d) + 646. Conclusions: The measurement of total sodium removal during the assessment of dialysis adequacy could be an effective and simple method to estimate dietary sodium intake in PD patients. A dietary intake of 2,000 mg of sodium corresponds to a total sodium removal of approximately 87 mEq/d.

임신중기 원인미상의 중증 양수과소증 임산부에서 시행한 반복 양수주입술 1예

김소미,송지은,박성호,전현아,김홍배,이근영 대한산부인과학회 2007 대한산부인과학회 학술대회 Vol.93 No.-

직장 유암종에 대한 내시경적 절제술 시행 후 12일째 발생한 대량 지연 출혈 1예

김소미,윤세영,최훈수,라성수,공재환 대한소화기내시경학회 2009 Clinical Endoscopy Vol.38 No.2

Endoscopic resection is currently accepted as a standard therapy for colon polyp because of its safety and efficiency. The indications for endoscopic resection have been expanded to treat mucosal colon cancer and submucosal tumor. The major complications of endoscopic resection are hemorrhage, perforation and post- polypectomy coagulation syndrome. Hemorrhage is the most common complication, and this can occur immediately following colonoscopic polypectomy or it can be delayed after completion of the procedure. Delayed hemorrhage usually occurs within 7 days and this can stop by itself or the hemorrhage can be controlled endoscopically in the majority of patients, with only the unusual and serious cases requiring transfusion, angiography and surgery. We experienced a case of delayed massive hemorrhage with hypotension that required transfusion 12 days after performing endoscopic resection for rectal carcinoid tumor. We report here on this case to provide a good example and to place emphasis on delayed massive hemorrhage after endoscopic resection. 내시경적 용종 절제술은 대장 용종의 표준 치료로 인정받고 있으며, 내시경 술기 및 기기의 발달로 내시경적 점막절제술 및 내시경적 점막하 박리술을 이용하여 점막에 국한된 조기 대장암 및 일부 점막하 종양의 치료로 발전하고 있다. 이와 같은 내시경적 절제술은 비교적 안전하며 삶의 질을 높일 수 있어 수술적 치료를 대체하고 있으나 출혈, 천공 및 용종 절제술 후 응고 증후군 등의 합병증이 발생할 수 있다. 내시경적 용종 절제술과 관련된 가장 흔한 합병증은 출혈로서 약 0.3∼6.1%에서 발생하며 시술 중에 발생하는 즉시 출혈과 시술 이후에 발생하는 지연 출혈로 나눌 수 있다. 지연 출혈의 경우 대부분 일주일 내에 소출혈의 양상을 보이게 된다. 저자들은 1.2 cm 크기의 직장 유암종을 내시경적 절제술로 제거한 후 조기 출혈 없이 퇴원하였으나, 시술 12일째 불안정한 활력 징후를 보이며 수혈 치료가 필요했던 대량 지연 출혈 1예를 경험하여 문헌 고찰과 함께 보고한다.

악력과 총 사망률, 원인별 사망률과의 연관성: 고령화 연구패널조사(2006–2016)

김소미,최송화,유정은,이정권 대한가정의학회 2019 Korean Journal of Family Practice Vol.9 No.5

Background: Grip strength has been found to be closely related to mortality and disease morbidity. In this study, we aimed to evaluate the relationship between grip strength and mortality in middle aged and elderly Koreans. Methods: Study subjects were selected from the participants of the Korean Longitudinal Study of Ageing from 2006 to 2016. The Cox proportional hazards model was used to analyze the association between grip strength, all-cause mortality, and cause-specific mortality according to age and sex, after adjusting for covariates. Results: The adjusted hazard ratio (HR) for all-cause mortality was decreased in the high grip strength group (male: HR=0.580, 95% confidence interval [CI]=0.478–0.704; female: HR=0.601, 95% CI=0.483–0.747) compared to the low grip strength group in both sexes. In male, cardiovascular mortality (middle group: HR=0.453, 95% CI=0.278–0.738; high group: HR=0.538, 95% CI=0.332–0.871) and cancer mortality (middle group: HR=0.697, 95% CI=0.514–0.945; high group: HR=0.589, 95% CI=0.427–0.812) were significantly lower in the middle and high grip strength groups compared to the low grip strength group. The HR for mortality due to stroke in male decreased significantly according to grip strength, but this became nonsignificant after adjusting for covariates. No association between cause-specific mortality and grip strength was found in female. Conclusion: In this study, grip strength was inversely associated with all-cause mortality, with similar effects on cause-specific mortality due to heart disease and cancer in male. Grip strength is a useful predictor of health status, and further studies are needed to evaluate its clinical relevance in Koreans. 연구배경: 악력은 간편하게 근력을 측정할 수 있는 도구로서 사망률 및 질병 이환율과 밀접한 연관이 있음이 밝혀지고 있으나 한국인을 대상으로 건강 장기 지표와의 연관성을 확인한 연구가 없어 중고령자 한국인을 대상으로 악력과 사망률의 관계에 대해 알아보고자 하였다. 방법: 고령화 연구패널조사(Korean Longitudinal Study of Ageing)의 1차 기본 조사 자료와 2년마다 추적 조사를 통해 얻은 사망자 자료를분석하였다. 성별과 연령에 따라 악력을 삼분위로 구분하여 악력에따른 총 사망률 및 심장 질환, 뇌졸중 및 암 사망률과의 연관성을Cox proportional hazard model을 이용하여 분석하였다. 연령, 학력,결혼 상태, 취업유무, 가구 총소득, 규칙적 운동 여부, 흡연, 음주,body mass index, activities of daily living 유무, instrumental activities ofdaily living 유무, 우울증, 만성질환(고혈압, 당뇨, 암, 심장 질환, 뇌혈관 질환) 유무를 보정하였다. 결과: 남녀 모두에서 저악력군에 비해 고악력군에서 총 사망률 위험비가 감소하였다(남자: HR=0.580, 95% CI=0.478–0.704; 여자:HR=0.601, 95% CI=0.483–0.747). 암 사망률의 경우 남성에서 저악력군에 비해 중, 고악력군에서 위험비가 유의미하게 감소하였고(중악력군: HR=0.697, 95% CI=0.514–0.945; 고악력군: HR =0.589, 95%CI=0.427–0.812) 여성에서는 통계적으로 유의하지 않았다. 심장 질환에 의한 사망률은 남성에서는 저악력군에 비해 중, 고악력군에서위험비가 낮았으나(중악력군: HR=0.453, 95% CI=0.278–0.738; 고악력군: HR=0.538, 95% CI=0.332–0.871) 여성에서는 통계적으로 유의하지 않았다. 뇌졸중에 의한 사망률의 경우 남성에서는 공변수를보정하기 전에는 악력 증가에 따른 위험비 감소가 유의미하였으나변수 보정 이후에는 유의미하지 않았고 여성에서는 통계적으로 의미 있는 결과가 나오지 않았다. 결론: 한국인 중고령자를 대상으로 악력과 총 사망률 및 남성에서심장 질환, 암 사망률과의 연관성을 확인하여 건강예측인자로서의악력의 가능성을 보였다. 한국인에서 연령에 따른 저악력의 기준을정하고 이에 따른 저악력자 선별 및 중재 효과에 대한 추가적인 연구가 필요하다.

스티렌 회분식 현탁중합에서 총괄열전달계수 변화에 따른 폭주반응 해석

김소미,이헌창,장서일,김태옥 한국공업화학회 2004 한국공업화학회 연구논문 초록집 Vol.2004 No.1

Maleated EPDM-Polydimethylsiloxane 공중합체를 Base로한 방진고무의 제조와 그 특성

김소미,강두환,임완빈 한국공업화학회 2004 한국공업화학회 연구논문 초록집 Vol.2004 No.1