복시를 주소로 내원한 에드하임-체스터병 1예

김세은,김숙영,김근해,Se Eun Kim,Sook Young Kim,Keun Hae Kim 대한안과학회 2014 대한안과학회지 Vol.55 No.2

Purpose: We present a case of Erdheim-Chester disease (ECD) with diplopia. Case summary: A 56-year-old woman came to the hospital with a 6-week history of diplopia on left lateral gaze. The right eye showed mildly limited adduction. Humphrey automated perimetry demonstrated inferior bitemporal quadrantanopia. Orbital and brain magnetic resonance imaging revealed well-defined orbital masses in both intraconal orbits with homogenous enhancement, as well as multiple masses of homogenous signal intensity in the brain. Systemic evaluation showed involvement of the long bones, and retroperitoneum, but no involvement of the heart, or lungs. Incisional biopsy of the right orbital mass was performed. Histopathological examination showed numerous lipid-laden histiocytes and few multinucleated Touton giant cells. Immunohistochemical staining showed positivity for CD68, but negativity for CD1a, and ECD was therefore diagnosed. The patient received treatment with radiation therapy and interferon-α, but died due to sepsis secondary to urinary tract infection after 2 months. Conclusions: Except exophthalmos, diplopia may be the only initial symptom of an orbital mass. Although rare, the possibility of ECD should be considered in the differential diagnosis of both retrobulbar and orbital masses with diplopia. J Korean Ophthalmol Soc 2014;55(2):283-288

홍삼사포닌 투여의 다낭성난소에 의한 불임 치료효과 및 기작연구

김세은,오동민,심경미,정문진,임성철,나승열,이윤렬,강성수,문창종,김종춘,김성호,배춘식,Kim, Se-Eun,Oh, Dong-Min,Sim, Kyung-Mi,Jeong, Moon-Jin,Lim, Sung-Chul,Nah, Seung-Yeol,Lee, Yun-Lyul,Kang, Seong-Soo,Moon, Chang-Jong,Kim, Jong-Choon,Kim 한국현미경학회 2009 Applied microscopy Vol.39 No.1

사람에서의 PCO와 몇몇 측면에서 유사한, 실험적으로 유발된 다낭성난소(polycystic ovary, PCO)는 장기간 작용하는 estradiol valerate (EV)에 의해 유발된다. 랫드에서 스테로이드로 유발한 PCO 모델에서 홍삼 총사포닌의 역할에 대한 우리의 이전연구는 전침이 난소의 nerve growth factor (NGF) 농도를 조절하는 것을 검증하였다. 실제로 PCO와 관련된 난소 기능부전의 병리기전에서 신경성 요소의 관련성은 난소로의 교감신경유출(sympathetic outflow)의 증가로 인해 높아진다. 따라서 본 연구에서는 치료제로서의 GTS 투여가 PCO를 유발한 랫드에서 교감신경 활성을 조절할 것이라는 가설을 시험해보고자 하였다. 본 연구에서는 스테로이드로 유발한 PCO에 내재하고 있는 병태생리학적 과정과 연관된 NGF 단백질과 NGF mRNA를 분석함으로써 이루어졌다. PCO가 유발된 랫드에서 EV 대조군은 oil 대조군과 비교하였을 때 유의적으로 높은 NGF mRNA의 발현을 나타내었으며, GTS 투여군은 EV 대조군에 비해 유의적으로 낮은 NGF mRNA의 발현을 나타내었다. 그러나 NGF 단백질은 oil 대조군에 비해 EV 대조군과 GTS 투여군에서도 유의적인 변화를 발견할 수 없었다. 이러한 결과는 EV가 설치류에서 낭종 형성과 무배란을 유발하는 병리학적 단계의 구성요소일 수 있는 난소의 신경향성 단계(neurotrophic state)를 조절한다고 생각할 수 있다. Experimental induction of polycystic ovary (PCO) resembling some aspects of human PCO syndrome was produced using the long-acting compound estradiol valerate (EV). Our previous study on the role of Korean red ginseng total saponins (GTS) in a steroid-induced PCO rat model demonstrated that electro-acupuncture modulates nerve growth factor (NGF) concentration in the ovaries. In fact, the involvement of a neurogenic component in the pathology of PCO-related ovarian dysfunction is preceded by an increase in sympathetic outflow to the ovaries. In the present study, we tested the hypothesis that therapeutic GTS administration modulates sympathetic nerve activity in rats with PCO. This was done by analyzing NGF protein and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. EV injection resulted in significantly higher ovarian NGF mRNA expression in PCO rats compared to control rats, and PCO ovaries were counteracted by GTS administration with significantly lower expression of NGF mRNA compared to EV treated ovaries. However, NGF protein was unaffected in both EV and GTS treated ovaries compared to control rats. These results indicate that EV modulates the neurotrophic state of the ovaries, which may be a component of the pathological process by which EV induces cyst formation and anovulation in rodents.

약용 식물의 암세포 다제내성 조절 활성 검색

김세은,황방연,김영호,김영중,이경순,이정준,Kim, Se-Eun,Hwang, Bang-Yeon,Kim, Young-Ho,Kim, Young-Choong,Lee, Kyong-Soon,Lee, Jung-Joon 한국생약학회 1997 생약학회지 Vol.28 No.4

Methanol extracts from 450 plants were screened for muttidrug-resistance reversing activity using drug sensitive KB-3-1 and multidrug-resistant KB-Vl cells. Among them, the extracts of Cynanchum wilfordii, Torilis japonica, Celastrus orbiculatus, Melia toosendan and Teminialia chebula strongly potentiated vinblastine cytotoxicity in KB-Vl cells. But their cytotoxicities to both sensitive KB-3-1 and resistant KB-Vl cells were in the same order of magnitude. These results indicate that the above samples would contain the active principles which do not exert their ativity solely by cytotoxicity.

국소성 분절성 사구체 경화증에 의한 영아형 신증후군 1례

김세은,한영심,송민섭,정우영,Kim Se Eun,Han Young Sim,Song Min Seop,Chung Woo Yeong 대한소아신장학회 1999 Childhood kidney diseases Vol.3 No.1

Focal Segmental Glomerulosclerosis(FSGS) is one of the underlying pathology of congenital and infantile nephrotic syndrome. There is no ultimate curative treatment except renal transplantation. We have experienced a case of infantile nephrotic syndrome In a 10 month old boy who presented with proteinuria and hematuria. His elder brother also suffered from nephrotic syndrome and died at the age of 18 months due to sepsis. We have diagnosed this patient with clinical manifestations, laboratory data and pathologic findings which was done by open renal biopsy. The patient expired 54 days after admission because or progressive uremia and sepsis.

섬유주세포에서 베바시주맙과 라니비주맙이 일산화질소합성효소의 발현에 미치는 영향

김세은,김재우,Se Eun Kim,Jae Woo Kim 대한안과학회 2014 대한안과학회지 Vol.55 No.8

Purpose: To compare the effects of bevacizumab and ranibizumab on the expression of eNOS in cultured human trabecular meshwork cells (HTMC). Methods: Primarily cultured HTMC were exposed to 0.5 mg/mL bevacizumab and ranibizumab using 1% serum-containing media for 30 minutes. Expression of eNOS mRNA was assessed with RT-PCR. Additionally, after exposure to 20 ng/mL of vascular endothelial growth factor (VEGF) and 0.5 mg/mL bevacizumab and ranibizumab, the production of nitric oxide was assessed with Griess assay. Results: VEGF increased the production of nitric oxide in HTMC. Bevacizumab and ranibizumab decreased the expression of eNOS mRNA and production of nitric oxide (<em>p</em> < 0.05) in HTMC. The decrease in eNOS mRNA expression and production of nitric oxide was not significant between bevacizumab and ranibizumab (<em>p</em> > 0.05). Conclusions: In HTMC, both bevacizumab and ranibizumab decreased the expression of eNOS mRNA with no significant difference observed between the two drugs. J Korean Ophthalmol Soc 2014;55(8):1208-1212

대학 캠퍼스 내 무인 식품 매점 운영에 대한 고객 요구도 분석

김세은,박민서,배현주,Kim, Se-Eun,Park, Min-Seo,Bae, Hyun-Joo 한국영양학회 2022 Journal of Nutrition and Health Vol.55 No.5

대학구성원의 식생활 개선을 위해 24시간 운영하는 '무인 식품 매점' 운영에 대한 고객 요구도를 총 329명을 대상으로 온라인 설문조사를 한 결과 조사대상자 중 남자는 31.3%, 여자는 68.7%였고, 1인 가구는 전체의 54.1%였으며, 아침식사 결식률은 39.2%였고, 섭취가 부족한 식품군은 과일류 (35.6%), 채소류 (32.8%) 순으로 높았다. 점심식사는 배달음식을 이용하는 경우가 32.2%로 가장 많았고, 점심식사로 선호하는 메뉴는 한식 (74.2%), 일품요리 (34.3%), 일식 (31.9%), 패스트푸드 (28.0%), 중식 (17.0%)의 순이었다. 점심식사와 점심식사 장소에 대한 전체적인 만족도는 평균 3.91점/5점이었고, 전체적인 만족도는 직접 조리해서 먹는 경우가 유의적으로 가장 높았고, 편의점에서 식사하는 경우가 가장 낮았으며 (p < 0.001), 가족과 식사하는 경우가 친구나 혼자 식사하는 경우보다 유의적으로 가장 높았다 (p < 0.001). 무인 매점 이용 의향은 평균 3.98점/5점으로, 직접 조리하는 경우 (3.76점)가 유의적으로 가장 낮았고, 편의점에서 식사하는 경우 (4.38점)가 유의적으로 가장 높았다 (p < 0.05). 무인 식품 매점 희망 이용 시간대는 점심시간 (54.1%), 저녁시간 (46.2%), 오후 간식 시간 (41.9%) 순이었고, 구입 희망 식품은 도시락류 (62.0%), 샌드위치류 (56.2%), 컵과일류 (54.4%), 샐러드류 (51.7%), 김밥류 (50.5%) 순이었다. 판매 예정 식품의 구입 희망 평균 가격은 도시락류는 4,991원, 샐러드류가 3,403원, 컵과일류는 2,745원, 샌드위치류는 2,609원, 김밥류는 2,235원이었다. 대학교 내 무인 매점 경영자는 무인 식품 매점의 성공적인 운영을 위해서 고객의 요구를 실시간 파악하여 고객만족을 극대화할 수 있는 효과적인 마케팅 전략을 수립해 나가야 할 것이다. Purpose: This study was performed to analyze customer needs for the operation of unmanned food stores on a university campus. Methods: A total of 329 responses were collected from customers who had purchased food at the stores. Statistical analyses were conducted using the SPSS program for frequency analysis, χ2-test, t-test, one-way analysis of variance, and Duncan's multiple range test. Results: On average, the overall satisfaction score for lunch and the eating location was 3.91 out of 5 points. Overall satisfaction was significantly higher for home cooking, and lower for eating at convenience stores (p < 0.001), and the score for eating with family was significantly higher than for eating alone or with friends (p < 0.001). On average, the intention to use an unmanned store received a score of 3.98 out of 5 points, while 'home cooking (3.76)' was significantly lower than other eating locations and eating at 'convenience stores (4.38)' was significantly higher than other eating locations (p < 0.05). The desired time of use for unmanned food stores was 'lunch (54.1%)', 'dinner (46.2%)', and 'afternoon snack (41.9%)', and the desired foods were 'doshirak (62.0%)', 'sandwich (56.2%)', 'fruit cup (54.4%)', 'salad (51.7%)', and 'kimbap (50.5%)'. There were significantly more opinions that single-person households would use unmanned food stores for dinner more than family households (p < 0.05), and significantly more willingness to purchase fruit cup (p < 0.05). The average prices (Korean won) that the subjects were willing to pay for the purchase of food were 4,991 for doshirak, 3,403 for salad, 2,745 for fruit cup, 2,609 for sandwich, and 2,235 for kimbap. Conclusion: For the successful operation of the unmanned food stores on the university campus, the store manager should grasp the customer's needs in real-time and establish an effective marketing strategy.

미니돼지에서 정상 폐 환기/관류 신티그라피

Se Eun Kim(김세은),Ho Jae Han(한호재),Kyung Mi Shim(심경미) 한국생명과학회 2010 생명과학회지 Vol.20 No.11

미니돼지에서 폐 환기/관류 신티그라피를 실시한 결과 환기스캔에서는 기능적 분포는 왼쪽 폐가 44.2%, 오른쪽 폐에서는 56.2%로 나타났으며, 관류스캔에서는 왼쪽 폐가 46.87%, 오른쪽 폐가 54.97% 임을 확인할 수 있었고 사람의 폐용적과 유사한 결과를 보임을 확인할 수 있었다. 또한 다른 방사성가스보다 짧은 시간을 필요로 하며 기계적 환기로도 스캔이 가능한 Technegas로 환기 스캔을 실시하여 미니돼지의 마취시간을 줄 일 수 있었으며 미니돼지에서 더 용이하게 폐기능을 측정할 수 있었다. 따라서 본 연구를 통해 폐 환기/관류 신티그라피가 미니돼지에서 정상 폐기능 및 폐질환과 관련된 실험을 할 때 폐기능을 측정하는 좋은 진단법이 될 수 있으며 미니돼지의 정상 폐기능에 관한 연구가 앞으로 폐질환과 관련된 미니돼지의 실험에 대한 정보를 제공할 수 있으리라 생각된다. Miniature pigs are widely used in experiments related to pulmonary disease because of their similarities with humans. However, there are not enough data about normal lung function in miniature pigs. Thus, in this study, we investigated normal lung function in miniature pigs with lung ventilation/perfusion scintigraphy and evaluated the availability of this method. Three male miniature pigs weighing 30-35 ㎏ were used. After general anesthesia, ventilation scintigraphy was performed with 100 MBq of <SUP>99m</SUP>Tc-pertechnetate (O₄?), after which perfusion scintigraphy was performed with intravenous injection of <SUP>99m</SUP>Tc-macro aggregated albumin (MAA). The functional contribution of the right lung was about 55%, and left lung was about 45%, similar to humans. Lung ventilation/perfusion scintigraphy was very useful in evaluating the normal lung function of miniature pigs because it was a non-invasive procedure (no tissue damage was involved), took a short time and was easy to perform. In conclusion, miniature pigs are similar to humans in functional contributions of the lung, and this method will be helpful in future pulmonary disease studies involving miniature pigs.

당뇨병 치료약제와 심혈관 질환

김세은 ( Se-eun Kim ),유병수 ( Byung-su Yoo ) 대한내과학회 2021 대한내과학회지 Vol.96 No.2

Diabetes is one of the important risk factors in cardiovascular disease associated with atherosclerosis, and cardiovascular disease is the leading cause of death in patients with diabetes mellitus. Recent randomized placebo-controlled cardiovascular outcome trials of all new antidiabetic drugs have linked SGLT-2 inhibitors and GLP1-agonists to not only increased cardiovascular stability but significant reduction of cardiovascular disease. These results have led to preferential selection of the most effective and beneficial antidiabetic drugs with the evidence of cardiovascular safety and efficacy. Herein, we address cardiovascular stability and the effectiveness of antidiabetic drugs, focusing on recently developed ones. (Korean J Med 2021;96:85-91)

리더의 카리스마와 개별적 배려가 미용종사자의 직무몰입과 업무성과에 미치는 영향 연구

김세은 ( Kim Se-eun ),오수연 ( Oh Su-yeon ) 한국미용학회 2017 한국미용학회지 Vol.23 No.5

As the cosmetology service industry is based on worker’s professional qualities and hence requires strong professional consciousness, it is expected that the influence of leadership will be high. Therefore, based on the previous studies, in this study, the charisma of leadership and individualized consideration were used as variables to investigate its’ effects on the cosmetology service worker’s job engagements and business performances. According to an empirical analysis, the study results found the following: First, in terms of the relationship between a leader’s charisma/individual considerations and job commitment, as a leader’s charisma and individual consideration increased, job commitment was higher. Second, in terms of the relationship between job commitment and job performances, as job commitment increased, job performances improved as well. This is because beauty practitioners are customized to service-oriented industries with a high level of interaction with customers and have a small number of human resources. Therefore, it is interpreted that, in order for the workers to form a sense of attachment and accomplishment to the work, the leaders should exercise leadership harmoniously by inculcating a clear sense of purpose and values and principle to the workers and allowing them to have selfesteem regarding their job and hence the work performance above their ability can be achieved. These results confirm that a leader’s charisma and individual considerations affect job commitment and job performances in the cosmetology service industry. It is anticipated that the importance of this study and necessity for its introduction are academically provided to cosmetology service industry.

The Virome Analysis Responsible for Growth Retardation in Cnidium officinale

Se Eun Kim(김세은),Davaajargal Igori,Jeong A Kwon(권정아),Jae Sun Moon(문제선) 한국약용작물학회 2023 한국약용작물학회 학술대회논문집 Vol.2023 No.1