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흰쥐의 허리척수분절에서 Vanilloid receptor 1 양성 일차감각 신경섬유의 해부학적 특성에 관한 연구
김성목(Seong Mok Kim),오정민(Jung Min Oh),Juli G. Valtschanoff, 백두진(Doo Jin Baik),황세진(Se Jin Hwang) 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.3
Capsaicin의 특이적 수용체로서 포유동물의 말초신경에서 capsaicin, 열감각 및 수소이온의 자극에 따른 감각을 수용하는 vanilloid receptor 1 (VR1)는 척수신경절에서 합성되어 말초신경뿐만 아니라 척수로도 이동된다. 본 연구자는 흰쥐의 하부 허리분절 및 상부 엉치척수(L4~S1)에서 VR1의 면역반응과 함께 연접이전부위의 표지물질 및 다양한 일차감각신경의 신경해부학적 표지물질들과 다중면역염색법을 실시하여 VR1양성 일차감각 신경종말의 분류 및 감각 신경종말내 분포양상을 연구하였다. VR1 양성 신경섬유 및 종말은 Rexed lamina I 및 II에서 관찰되었다. L4~L5분절에서 lamina I에 존재하는 VR1 양성민말이집 섬유말단은 소수의 CGRP 및 substance P 양성 신경종말과 공존하였으며 일부종말은 궁둥신경으로부터 주입, 추적된 choleratoxin-B subunit 양성 말이집 섬유종말과도 공존하였고, lamina II에서는 주로 isolectin B4 (IB4)와 공존하였다. 또한 lamina I의 VR1 양성 신경종말은 neurokinin I (NK1) 및 glutatmate 수용체 양성 신경세포 및 가지돌기와 연접을 이루고 있었다. L6~S1분절에서 VR1 양성 신경종말은 뒤가쪽로에 특히 밀집되어 있었으며, lamina I-V 및 내장감각신경의 경로인 medial collateral path (MCP) 및 lateral collateral path (LCP)에서도 관찰되었다. VR1과 substance P는 뒤가쪽로와 LCP의 대부분의 신경섬유와 종말에서 공존하였다. 이상의 소견을 종합할 때 VR1 양성 일차감각 신경섬유는 IB4 양성 및 펩타이드성 일차감각 신경섬유와 부분적으로 중복되는 신경섬유로, 몸통 및 내장성 감각을 전달하는 펩타이드 및 비 펩타이드성 종말을 지니며, 특히 내장감각의 전달에 펩타이드성 VR1 양성 신경종말이 관여하는 것으로 판단된다. Primary afferents sensitive to capsaicin and noxious heat express vanilloid receptor 1(VR1) in both their peripheral and central fibers and terminals. We used multiple immunofluorescence and confocal microscopy to characterize their pattern of termination in rat spinal cord, colocalization of neurochemical markers of primary afferents and other presynaptic receptors. VR1-positive unmyelinated fibers mainly terminate in lamina I, where they co-stain for CGRP, and to a limited extent for SP, and in lamina II, especially its medial half, where they co-stain for IB4. VR1 positive thin myelinated fibers terminate in lamina I and co-stain for the neurochemical tracer CTB, injected in the sciatic nerve. As revealed by simultaneous staining for the synaptic marker synaptophysin, VR1-positive terminals are abundant in lamina I and sparse in lamina II. In L6-S1 spinal cord, VR1-positive fibers and terminals were abundant in Lissauer’s tract, lamina I-V, medial collateral path to lamina X, and lateral collateral path to sacral parasympathetic nucleus. Most of VR1 positive fibers in Lissuer’s tract and LCP are colocalized with SP. In conclusion, it is suggested that VR1 positive fibers in spinal cord are both peptidergic and non-peptidergic, IB4 positive fibers, mediating both somatic and visceral sensations, and that peptidergic VR1 positive fibers are mainly related with visceral sense.
김성목(Seong-Mok Kim),정예은(Ye-Eun Jeong),김예준(Ye-Jun Kim),김용수(Yong Soo Kim) 한국신뢰성학회 2023 신뢰성응용연구 Vol.23 No.1
Purpose: Tire maintenance is essential for safety, as tire failure can cause significant damage to human health and infrastructure during light rail operations. Therefore, we developed a diagnostic algorithm for light rail rubber tires to prevent such catastrophic events. Methods: Vibration signals measured by tri-axis accelerometers were acquired during real-world light rail operation, and we compared vibrations among various tire states, established a health index, and developed a model for determining tire state. Results: The most important type of vibration in terms of tire state was x-axis vibration. Our model determined tire states by calculating x-axis vibration differences in various tire conditions. Furthermore, high model accuracy was confirmed by stratified k-fold cross-validation. Conclusion: Our diagnostic algorithm for determining tire condition reduces operating and support costs and promotes reliability and safety by enabling timely and appropriate maintenance that considers the age of individual tires. Thus, it could replace existing time-based maintenance protocols.
원료 생약 추출물의 최적화를 위한 한국 5개 지역에서 채집된 대계 추출물들의 항우울 효과 비교
장미란(Miran Jang),이혜림(Hye Lim Lee),홍은영(Eunyoung Hong),김성목(Seong Mok Kim),윤서영(Seo Young Yoon),준브라이언(June Bryan I. dela Pena),김건희(Gun-Hee Kim),정재훈(Jae Hoon Cheong),이용수(Yong Soo Lee) 大韓藥學會 2012 약학회지 Vol.56 No.6
Previously, we identified that Cirsium japonicum (CJ) extract posses antidepressant properties. In order to look for the optimal hebal preparation, CJ extracts collected from Koheung, Yesan, Cheju, Pyungchang and Pocheon were compared. The psychopharmacological activities of each extract were investigated using the open field test, the rota-rod test and the forced swimming test. Effect of each extract on Cl- influx in neuroblastoma cells were also identified. All of the extracts were orally administered at dosages of 50, 100, 200, 400 mg/kg of body weight. Supplementation of CJ did not significantly alter psychomotor behaviors such as movement, rearing frequency and total turn angle on the open field. Supplementation of CJ’s extract from Pyungchang (100 mg/kg, p.o.), Cheju (200 and 400 mg/kg p.o.) and Yesan (100 and 200 mg/kg, p.o.) significantly decreased immobile duration and increased mobile duration in the forced swimming test. All of extracts have no influence on NE uptake in HEK-293 cells, but increased Cl- influx in neuroblastoma cell. The extract from Yesan demonstrated the most potent effect on Cl- influx. These results indicate that CJ’s extracts from Pyungchang, Cheju and Yesan may alleviate depression, and the extract from Yesan may be the most effective preparation.