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백서(白鼠)에서 오공약침(蜈蚣藥鍼)이 신경병증성(神經病症性) 통증(痛症)에 미치는 영향(影響)
이삼로 ( Sam Ro Lee ),김성철 ( Sung Chul Kim ),구성태 ( Sung Tae Koo ),김성남 ( Sung Nam Kim ),황우준 ( Woo Jun Hwang ),이건목 ( Geon Mok Lee ),조남근 ( Nam Geun Cho ),임규상 ( Kyu Sang Lim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.2
Objectives: In the present study, the effect of Scolopendrid Water-Alcohol Extract (SWAE) applied to acupuncture point BL23 (Shinsu) on the neuropathic pain was examined. A common source of persistent pain in humans is the neuropathic pain. Anti-convulsant drugs are used to treat the neuropathic pain. In the oriental medicine, Scolopendrid was used for long time to treat convulsant syndrome and back pain, etc. Methods: On the bases of the Scolopendrid clinical application, the effect of SWAE applied to the acupuncture point was tested in the rat model of neuropathic pain. Neuropathic pain was induced by tight ligation of L5 spinal nerve. When rats developed pain behaviors, One hundred microliter of SWAE was applied into the ipsilateral BL23 point at a dose of 10 mg/ml under enflurane anesthesia. The foot withdraw latency of the hind limb was measured for an indicator of pain level after each manipulation. Results: SWAE injection increased the mechanical threshold of the foot in the rat model of neuropathic pain significantly for the duration of 4h, suggesting a partial alleviation of pain. SWAE applied to BL23 point produced a significant improvement of mechanical sensitivity of the foot lasting for at least 4h. However, neither contralateral BL23 point, ST25 (Chonchu) point, nor LR3 (Taechung) point produce as much increase of mechanical sensitivity as ipsilateral BL23 point. And, this increase of mechanical sensitivity was dose-dependent. The improvement of mechanical threshold was interpreted as an analgesic effect. In addition, the analgesic effect of Scolopendrid 4 mg/kg injection is equivalent to that of gabapentin 50 mg/kg injection. The relations between SWAE-induced analgesia and endogenous nitric oxide(NO), inducible NO synthase (iNOS)/neuronal NO synthase (nNOS) were also examined. Results were turned out that both NO production and nNOS/iNOS protein expression which are increased by nerve injury were suppressed by SWAE injection applied to BL23 point. Conclusions: The data suggest 1) that SWAE produces a potent analgesic effect on the neuropathic pain model in the rat and 2) that SWAE-induced analgesia modulate endogenous NO through the suppression of nNOS/iNOS protein expression.
백서(白鼠)에서 오공약침(蜈蚣藥鍼)이 신경병증성(神經病症性) 통증(痛症)에 미치는 영향(影響)
이삼로,구성태,김성남,황우준,이건목,조남근,임규상,김성철,Lee, Sam-Ro,Koo, Sung-Tae,Kim, Sung-Nam,Hwang, Woo-Jun,Lee, Geon-Mok,Cho, Nam-Geun,Lim, Kyu-Sang,Kim, Sung-Chul 경락경혈학회 2004 대한침구의학회지 Vol.21 No.2
Objectives : In the present study, the effect of Scolopendrid Water-Alcohol Extract (SWAE) applied to acupuncture point BL23 (Shinsu) on the neuropathic pain was examined. A common source of persistent pain in humans is the neuropathic pain. Anti-convulsant drugs are used to treat the neuropathic pain. In the oriental medicine, Scolopendrid was used for long time to treat convulsant syndrome and back pain, etc. Methods : On the bases of the Scolopendrid clinical application, the effect of SWAE applied to the acupuncture point was tested in the rat model of neuropathic pain. Neuropathic pain was induced by tight ligation of L5 spinal nerve. When rats developed pain behaviors, One hundred microliter of SWAE was applied into the ipsilateral BL23 point at a dose of 10 mg/ml under enflurane anesthesia. The foot withdraw latency of the hind limb was measured for an indicator of pain level after each manipulation. Results : SWAE injection increased the mechanical threshold of the foot in the rat model of neuropathic pain significantly for the duration of 4h, suggesting a partial alleviation of pain. SWAE applied to BL23 point produced a significant improvement of mechanical sensitivity of the foot lasting for at least 4h. However, neither contralateral BL23 point, ST25 (Chonchu) point, nor LR3 (Taechung) point produce as much increase of mechanical sensitivity as ipsilateral BL23 point. And, this increase of mechanical sensitivity was dose-dependent. The improvement of mechanical threshold was interpreted as an analgesic effect. In addition, the analgesic effect of Scolopendrid 4 mg/kg injection is equivalent to that of gabapentin 50 mg/kg injection. The relations between SWAE-induced analgesia and endogenous nitric oxide(NO), inducible NO synthase (iNOS)/neuronal NO synthase (nNOS) were also examined. Results were turned out that both NO production and nNOS/iNOS protein expression which are increased by nerve injury were suppressed by SWAE injection applied to BL23 point. Conclusions : The data suggest 1) that SWAE produces a potent analgesic effect on the neuropathic pain model in the rat and 2) that SWAE-induced analgesia modulate endogenous NO through the suppression of nNOS/iNOS protein expression.
장성호,구삼옥,신영기,김성남,강유원,윤여일,김진수,Chang Sung-Ho,Koo Sam-Ok,Shin Young-Gi,Kim Sung-Nam,Kang Yoo-Won,Yun Yeu-Il,Kim Jin-Soo 한국군사과학기술학회 2005 한국군사과학기술학회지 Vol.8 No.1
Due to small and light mission payloads, subsystems and propulsion system, small sized UAVs come to be available for reconnaissance that have been performed by aircraft and huge UAVs. The objective of this study is to develop an efficient propulsion system for small reconnaissance UAVs. A glow engine was modified for an efficient and robust 4-stroke gasoline engine with carburetor, new electronic control unit and lubrication system. Engine modification technique and small engine performance test stand are capable of economical method for military UAVs.