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수종 생약추출물의 NMDA(N-Methyl-D-Aspartate) 수용체 glycine binding site에 대한 친화력 검색
김영섭,김정섭,김성기,허정희,이병의,유시용,Kim, Young-Sup,Kim, Jeoung-Seob,Kim, Seong-Kie,Heor, Jung-Hee,Lee, Byung-Eui,Ryu, Shi-Yong 한국생약학회 2001 생약학회지 Vol.32 No.3
The water extracts of 82 Korean medicinal herbs were prepared and were examined for the binding affinity on the glycine binding site of NMDA (N-methyl-D-aspartate) receptor prepared by the synaptic membranes from the forebrains of male Sprague-Dawley rats. Among the tested, the extracts of Dioscoreae Rhizoma, Hoveniae Semen cum Fructus, Astragali Radix, Armeniacae Semen, Huttuynia cordata Herba, Acanthopanacis Cortex, Aurantii nobilis Pericarpium, Phellinus linteus, Amomi Fructus, Artemisiae capillaris Herba, Polyporus, Agastachis Herba and of Galli Stomachichum Corium were found to exhibit significant competitions with $[^3H]-MDL$ 105,519 for the glycine specific binding site of NMDA receptor in a dose dependent manner, respectively.
수종 생약추출물의 muscarin성$(M_1\;type)$ acetylcholine 수용체$(mAChR-M_1)$에 대한 친화력 검색
김영섭,김정섭,김성기,허정희,이병의,유시용,Kim, Young-Sup,Kim, Jeoung-Seob,Kim, Seong-Kie,Heor, Jung-Hee,Lee, Byung-Eui,Ryu, Shi-Yong 한국생약학회 2001 생약학회지 Vol.32 No.3
The water extracts of 82 Korean medicinal herbs were examined for the binding affinity on the recombinant human muscarinic acetylcholine receptor subtype 1 $(mAChR-M_1)$ produced from the CHO (Chinese Hamster Ovary) cell line. Of those tested, the extracts of Coptidis Rhizoma, Phellodendri Cortex, Hedyotis Herba and of Terminariae Fructus were found to exhibit a significant competition with $[^3H]$ N-methyl-scopolamine for the specific binding to $mAChR-M_1$ in a dose dependent manner, respectively.