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Curcumin과 resveratrol에 의한 두경부암 유래의 HN-4 세포의 세포주기, 세포사 및 전이관련 단백질의 발현 조절
김사엽(Sa-Yub Kim),이상한(Sang-Han Lee),권택규(Taeg-Kyu Kwon) 대한구강악안면외과학회 2003 대한구강악안면외과학회지 Vol.29 No.5
Nontraditional or alternative medicine is becoming an increasingly attractive approach for the treatment of various inflammatory disorders and cancers. Curcumin is the major constitute of turmoric powder extracted from the rhizomes of the plant Curcuma longa. Resveratrol is a phytoalexin present in grapes and a variety of medicinal plants. In this report, We investigated the effect of curcumin and resveratrol on regulatory protein of cell cycle, induction of apoptosis and MMP activity. Treatment with 75 M curcumin for 24 hrs produced morphological changing in HN-4 cells. Curcumin and resveratrol inhibited the cellular growth in HN-4 cells. Inhibition of cell growth was associated with down-regulation of cell cycle regulatory proteins. Curcumin-induced caspase-3 activation and Bax degradation were dose-dependent with a maximal effect at a concentration of 100 M. The elevated caspase-3 activity in curcumin treated HN-4 cells are correlated with down-regulation of survivin and cIAP1, but not cIAP2. Curcumin induced a dose-dependent increase of cytochrome c in the cytosol. Curcumin induced-apoptosis was mediated through the release of cytochrome c. In addition, curcumin-induced apoptosis was caused by the generation of reactive oxygen species, which was prevented by antioxidant N-acetyl-cysteine (NAC). Cotreatment with NAC markedly prevented cytochrome c release, Bax cleavage and cell death. Also resveratrol-induced apoptosis was preceded by down-regulation of the anti-apoptotic Bcl-2, cIAP1, and caspase-3 activity. However, resveratrol-induced apoptosis was not prevented by antioxidant NAC. In addition, HN-4 cells release basal levels of MMP2 when cultured in serum-free medium. Treatment of the cells with various concentrations of PMA for 24 hr induced the expression and secretion of latent MMP9 as determined by gelatin zymography. HN-4 cells were treated with various concentrations of curcumin and resveratrol in the presence of 75 nM PMA, and MMP2 and 9 activities were inhibited by curcumin and resveratrol.
이상한(Sang Han Lee),김진수(Chin Soo Kim),장현중(Hyun Jung Jang),김준연(Joon Yeun Kim),김사엽(Sa Yub Kim) 대한구강악안면외과학회 1990 대한구강악안면외과학회지 Vol.16 No.1
Hemangiomas are relatively common tumors which are characterized by a proliferation of blood vessels. These lesions are usually present from birth and are considered by most to be hamartomas rather than true neoplasms. A variant of this entity is the intramuscular hemangioma, a tumor arising within normal skeletal muscle ; these comprise less than 1 percent (0.89) of all hemangiomas. Most intramuscular hemangiomas occur in the trunk and extremities, where there is larger muscle volume. Approximately 10 percents of the lesions occur in the head and neck region. The management of oral and perioral hemangiomas and the mode of therapy employed depend on several factors including the age of the patient, the size and extent of the lesion, as well as its clinical characteristics. Presented is a case report of intramuscular hemangioma on masseter treated with surgical excision combined with microembolization of feeding vassels, right facial artery.
우측 상악동 및 측두하간극에 걸쳐 발생한 선낭포성암의 치험례
장도근(Do Geun Jang),이용규(Yong Gyoo Lee),김사엽(Sa Yub Kim),김준연(Joon Yeun Kim),김진수(Chin Soo Kim) 대한구강악안면외과학회 1993 대한구강악안면외과학회지 Vol.19 No.4
This is a case report of adenoid cystic carcinoma on the right maxillary antrum and infratemporal space. The treatment of adenoid cystic carcinoma is chiefly surgical, although in some case surgery has been successfully coupled with radiation. The patient, aged 52 female, developed a pain involving the right side of face was diagnosed adenoid cystic carcinoma and treated with right tootal maxillectomy, preserving the inferior orbital rim of the right orbit, radical neck dissection performed and postoperative radiation therapy. No recurrence has been observed for 3.9 years. We will examine. Periodically the patient because of its poor prognosis and high recurrence during long term.
Pentoxifylline과 고압산소요법이 백서 무축 피판 생존율에 미치는 영향
김사엽,이상한 慶北大學校 齒科大學 1991 慶北齒大論文集 Vol.8 No.2
The effects of pentoxifylline, hyperbaric oxygen and combination of the two on the survival rate of random pattern skin flaps were evaluated in an experimental study in rats. Thirty-five rate were divided into five groups. Cephalic based random pattern flaps were designed on the back of the rats and control group animals received twice-daily an intraperitoneal injection of 1cc normal saline solution for seven days before surgery and every 12 hours after the operation for seven days and to control for the stress of injection. Group I rats were treated with pentoxifylline received 20 ㎎/kg intraperitoneally at 24, 12, and 1 hour(s) before flap elevation and every 12 hours after the operation for seven days. Group Ⅱ rats were treated with twicedaily pentoxifylline injections for seven days before surgery and were then managed as Group I. Group Ⅲ rats were treated with hyperbaric oxygen within four hours after flap operation. Group Ⅳ rats were given exactly as Group Ⅱ and Group Ⅲ. The survival rate to the total flap was calculated. The results were as follows: 1. The mean survival rate of the flaps was 54.60±16.78% in control, 61.34±10.62% in group I, 64.96±3.08% in group Ⅱ, 71.93±9.26% in group Ⅲ, 86.67±8.17% in group Ⅳ. 2. The survival rate of the flaps were increased in group Ⅰ,Ⅱ, Ⅲ, Ⅳ when compared with the control group. 3. The combination of pentoxifylline and hyperbaric oxygen showed synergistic effect on the survival rate of the flap. 4. In the histopathologic study at postoperative 7th day, abundant proliferation of fibroblast and capillary blood vessels were observed in the experimental Ⅲ group, while severe infiltration of inflammatory cells were observed in the control group.