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반복적 천명을 보이는 영유아에서 아토피 지표로서 총 호산구수 , 총 lgE 농도 및 집먼지진드기 항원 감작에 관한 연구
김봉성(Bong Seong Kim),심정연(Jung Yeou Shim),홍수종(Soo Jong Hong) 대한천식알레르기학회 2001 천식 및 알레르기 Vol.21 No.1
Background : Recurrent wheezing is probably related to airway hyperresponsiveness. Many young infants wheeze during viral lower respiratory tract infections, but the pathogenesis of these episodes and their relation to the development of asthma or other allergic disease later in life are not well understood. Whether environmental allergen exposure affects the inception of asthma remains to be determined. Objective : We performed this study to determine whether recurrent wheezing in infancy is related to atopy and if so, when infantile asthmatics become sensitized to house dust mite allergens. Methods : In a cross-sectional study, we investigated the factors related to recurrent wheezing before the age of three. A total of 119 infants were selected for this study and they were divided into two groups : 88 infants who experienced wheezing episodes more than three times before the age of two as infantile asthmatics, and 31 infants who had never experienced wheezing before visiting our hospital between January 1998 and July 1999. For these subjects, we performed assessments including measurement of peripheral total eosinophil counts, serum total IgE levels, specific IgE levels (Dermatophagoides pteronyssinus, Dermatophagoides farinae and food allergens) and questionnaires were completed by the children's parents. Results : The group who experienced recurrent wheezing showed significantly higher total eosinophil counts, serum concentrations of total IgE, D.p- and D.f-specific IgE than controls (p <0.05). There were no significant differences in the history of respiratory disease, familial history of allergic disease and environmental factors(domestic animals, bed cloth, carpet, smoking etc) between the group with recurrent wheezing and controls. The group who experienced recurrent wheezing showed significantly higher total eosinophil counts among those over 12 months old, and serum concentration of total IgE among those under 12 months old than controls(p<0.05). The concentration of D.p-specific IgE, but not D.f-specific IgE, in the recurrent wheezing group was higher than controls who were aged over 24 months(p<0.05). Conclusion : The infants with recurrent wheezing are strongly related to a predisposition to atopy. Eosinophilia is one of the important markers of recurrent wheezing. The period of sen- sitization of inhalant allergens like a D.p occurs as early as 24 months old. These findings suggest that early recognition of atopy and environmental controls are important to manage re- current wheezing in infants. (J Asthma Allergy Clin Immunol 21: 40-49, 2001)
천식 환아에서 집먼지진드기 항원을 이용한 면역요법이 혈액내 호산구, 항원-특이 IgE, 피부반응도 및 기도과민성에 미치는 영향
김봉성 ( Bong Seong Kim ),김자형 ( Ja Hyung Kim ),이소연 ( So Yeon Lee ),홍수종 ( Soo Jong Hong ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2003 소아알레르기 및 호흡기학회지 Vol.13 No.1
목적:집먼지진드기 항원에 감작된 천식환아에서 집먼지진드기 항원을 이용한 면역요법은 효과가 있는 것으로 알려져 있으나, 그 기전은 명확히 알려져 있지 않다. 본 연구는 소아 천식 환아에서 면역요법이 말초혈액 호산구수, 항원 특이 IgE, 피부반응도 및 기도과민성에 어떠한 영향을 유도하는지 조사하였다. 방법:D.f 및 D.p를 이용하여 고식적인 방법으로 면역치료를 받은 D.f 및 D.p에 감작된 소아 천식환자 24명과 대조군으로 D.f 및 D.p에 감작된 Purpose: Immunotherapy(IT) with house dust mite may be effective to treat house dust mite allergic disease, but the mechanism and prognostic index of IT are not completely understood. Generally allergen specific-IgE antibody significantly initially increa
분만 방법이 소아 천식의 발생에 영향을 미칠 수 있는가?
김봉성 ( Bong Seong Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.4
Under the hygiene hypothesis, children born by cesarean section (CS) may consequently have an increased risk of asthma and other allergic diseases. CS has been shown to have a delayed and altered development in establishment of gut flora and altered cytokine production. Concerns about the relations between CS and the risk of children`s asthma are rising due to the growing number of CS performed in many countries. However, finding the concrete evidence to correlate CS with higher risk of asthma is still controversial. There were significant covariate imbalance between groups of children born by CS vs. vaginal delivery that include the number of maternal age, gestational age, birth weight, complication during pregnancy, complication during labor, socioeconomic status, a parental history of atopy, and maternal smoking history. And there were considerable heterogeneity in methods and study subjects between the studies of delivery by CS and the offspring`s risk of asthma and other allergic diseases. Therefore, as we proceed into the further study, researchers must refer to the literatures and look for the best way proving their hypothesis that are based on the methodological subject group. Of which should be accordance with the research purposes. Also, researchers have to search for identifying the core biological mechanism in order to know whether there is a causal relationship exists between the CS and asthma. (Pediatr Allergy Respir Dis(Korea) 2011;21:250-260)
천식 환아에서 집먼지진드기 항원을 이용한 급속 면역요법후 체액성 면역 반응의 조기 변화에 대한 연구
김봉성(Bong Seong Kim),이수걸(Soo Keol Lee),박해심(Hae Sim Park),홍수종(Soo Jong Hong) 대한천식알레르기학회 2001 천식 및 알레르기 Vol.21 No.3
Purpose: Rush immunotherapy (RIT) with house dust mite may be effective to treat house dust mite allergic disease, but the mechanisms are not clear. Considerable attention has been devoted to the IgG subclass in relation to clinical outcome. Usually, conventional immunotherapy with D.f and D.p is followed early on by a rise in allergen-specific IgG1 with a gradual decline over time and slow rise in allergen-specific IgG4. Some investigators have implicated that IgG4 is a more important blocking antibody than IgG1 in RIT. But there is no consistent data on the early changes of allergen-specific IgG1 or IgG4. To inves- tigate the alteration of humoral immunity in the mechanism of early phase of RIT, the D.f -specific IgE, IgG1, and IgG4 levels of the RIT group were compared with that of the con- trol group with asthma. Method: The RIT group included 17 D.f and D.p-sensitized asthmatic children, who had received RIT with D.f and D.p, and the control group included 15 D.f and D.p-sensitized asthmatic children who had not received RIT. They received RIT to mite for just over 8 weeks until maintenance was achieved. The symptom scores of asthma, skin reactivity to D.f (allergen/histamine ratio), RIT changes of D.f-specific IgE, IgG1, and IgG4 levels were compared before and 8 weeks after for the two groups. D.f-specific IgE, IgG1, and IgG4 levels were measured by ELISA. Results: The symptom scores and the skin reactivity to D.f decreased significantly 8 weeks after RIT. D.f-specific IgG1 levels increased significantly 8 weeks after RIT in the RIT group but not in the control group. But D.f-specific IgE and D.f- specific IgG4 levels did not change 8 weeks after RIT in either of the two groups. Conclusion: D.f-specific IgG1 production was increased in the early phase of RIT. These findings suggest that the early clinical changes after RIT may be linked to the early increase of IgG1 blocking antibody. (J Asthma Allergy Clin Immunol 21: 543-551, 2001)
한국 3개 지역 고등학생에서 알레르기질환의 유병률에 대한 조사
김봉성 ( Bong Seong Kim ),김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),김자형 ( Ja Hyeung Kim ),진현승 ( Hyun Seung Jin ),김병주 ( Byung Ju Kim ),유진호 ( Jin Ho Yu ),유선미 ( Sun Mi Yoo ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.3
Background: Whereas allergic disease has a high morbidity among adolescents, there have been few reports concerning asthma prevalence using objective parameters such as methacholine bronchial provocation tests in this age group. Objective: Thus we investigate the prevalence of asthma and other allergic diseases using questionnaires and measuring bronchial hyperresponsiveness (BHR) in high school students in Korea. Method: A questionnaire survey was conducted among 1499 high school students, from 3 regions in Korea between April and May, 2006. They responded to a modified International Study of Asthma and Allergies in Childhood (ISAAC) written (WQ) and video (AVQ) questionnaires. 709 subjects of them underwent methacholine bronchial challenge test. Result: The WQ showed that the lifetime and 12-month prevalences of wheeze were 16.0% and 8.9%. The lifetime prevalence of asthma diagnosis was 7.0% and 12-month prevalence of asthma treatment was 1.5%. By video questionnaire, the lifetime prevalence and 12-month prevalence of wheeze were 7.9% and 5.5%. The prevalence of current asthma based on the questionnaire and bronchial challenge tests was 3.2%. The prevalence of current asthma and BHR were higher in female than in male subjects. For 12-month prevalence of allergic rhinitis and atopic dermatitis were 37.7% and 11.4%, respectively. Conclusion: The prevalence of current asthma in high school students were 3.2%. Despite the fact that 12-month prevalence of wheeze and lifetime prevalence of asthma diagnosis were 8.9% was 7.0%, only 1.5% of answered subjects received asthma treatment. Its prevalence was still low compared to asthma prevalence. (Korean J Asthma Allergy Clin Immunol 2007;27:168-175)