유방 부분 절제술 후 방사선 치료 시 TOMO Direct를 이용한 접선 조사의 선량적 유용성에 관한 고찰

김미정,김주호,김훈겸,조강철,전병철,조정희,Kim, Mi-Jung,Kim, Joo-Ho,Kim, Hun-Kyum,Cho, Kang-Chul,Chun, Byeong-Chul,Cho, Jeong-Hee 대한방사선치료학회 2011 대한방사선치료학회지 Vol.23 No.1

Purpose: Investigation of the clinical use of tangential fields technique using TOMO direct in comparison to conventional LINAC based radiation therapy after breast partial mastectomy. Materials and Methods: Treatment plans were created for 3 left-sided breast cancer patients who had radiation therapy after breast partial mastectomy by using wedged tangential fields technique, field in field technique (FIF), TOMO Direct, TOMO Direct intensity modulated radiation therapy (IMRT) under the normalized prescription condition ($D_{90%}$: 50.4 Gy/28 fx within CTV). Dose volume histogram (DVH) and isodose curve were used to evaluate the dose to the clinical target volume (CTV), organ at risk (OAR). We compared and analyzed dosimetric parameters of CTV and OAR. Dosimetric parameters of CTV are $D_{99}$, $D_{95}$, Dose homogeneity index (DHI: $D_{10}/D_{90}$) and $V_{105}$, $V_{110}$. And dosimetric parameters of OAR are $V_{10}$, $V_{20}$, $V_{30}$, $V_{40}$ of the heart and $V_{10}$, $V_{20}$, $V_{30}$ of left lung. Results: Dosimetric results of CTV, the average value of $D_{99}$, $D_{95}$ were $47.7{\pm}1.1Gy$, $49.4{\pm}0.1Gy$ from wedged tangential fields technique (W) and FIF (F) were $47.1{\pm}0.6Gy$, $49.2{\pm}0.4Gy$. And it was $49.2{\pm}0.4$ vs. $48.6{\pm}0.8Gy$, $49.9{\pm}0.4$ vs. $49.5{\pm}0.3Gy$ Gy for the TOMO Direct (D) and TOMO Direct IMRT (I). The average value of dose homogeneity index was W: $1.1{\pm}0.02$, F: $1.07{\pm}0.02$, D: $1.03{\pm}0.001$, I: $1.05{\pm}0.02$. When we compared the average value of $V_{105}$, $V_{110}$ using each technique, it was the highest as $34.6{\pm}9.3%$, $7.5{\pm}7.9%$ for wedged tangential fields technique and the value dropped for FIF as $16.5{\pm}14.8%$, $2.1{\pm}3.5%$, TOMO direct IMRT as $7.5{\pm}8.3%$, $0.1{\pm}0.1%$ and the TOMO direct showed the lowest values for both as 0%. Dosimetric results of OAR was no significant difference among each technique. Conclusion: TOMO direct provides improved target dose homogeneity over wedged tangential field technique. It is no increase the amount of normal tissue volumes receiving low doses, as oppose to IMRT or Helical TOMO IMRT. Also, it simply performs treatment plan procedure than FIF. TOMO Direct is a clinical useful technique for breast cancer patients after partial mastectomy.

재현의 곤경, 설득의 서사 넘기 ― 5월 광주 서사의 현재와 과제 ―

김미정 ( Kim¸ Mi-jung ) 현대문학이론학회 2020 現代文學理論硏究 Vol.0 No.83

오늘날 재현을 질문하는 과정 자체가 아이러니하게도, 백래쉬와 경합하는 장이 되기도 한다. 재현에 대한 문제의식이 궁극적으로 어떤 언설과 연결될지 가늠하는 것도 중요해졌다. 본 논문은, 오늘날 재현의 윤리에 대한 질문이, 대중적 백래쉬의 정동과 교착하는 장면들에 대한 문제의식에서 출발했다. 최근 빈번히 발견되는 설득의 서사구조에서도 이런 우려를 생각해볼 수 있다. 이러한 서사구조는 백래쉬와 부정의 언설 앞에서 스스로를 증명해야 하는 강박과 관련될 것이다. 그런데 그 설득의 과정 자체가 재현에 대한 오인을 발생시키곤 한다.. 오늘날 서사 속 5월 광주 재현이 처한 곤경도 이러한 재현 일반의 문제와 연동한다. 1990년대 이후 제도화, 공식화한 언어와 상상력을 공회전하면서 5월 광주 재현은 부정, 백래쉬 앞에서 무력해지곤 한다. 이것은 같은 언어를 공유, 활용하고 있는 조건과 장의 문제이기도 하다. 이 글은, 영화 <김군>(2018), 최윤 소설 「저기 소리 없이 한 점 꽃잎이 지고」(1988)를 재독해하면서 이러한 5월 광주 서사의 현재와 과제를 가늠하고자 했다. This study started with the problem of the scenes where the question about the ethics of representation today intersects with the affect of popular backlash. Ironically, the process of questioning representation itself becomes a field to compete with opposing forces. Therefore, it is also necessary to carefully assess what kind of discourse will ultimately lead to the problem about representation today. This concern can also be considered in the narrative structure of persuasion, which is frequently discovered recently. This narrative structure will be related to the intention to prove oneself in front of backlash and denial. However, the process of persuasion itself causes misconceptions about representation. In today's narrative, the predicament of the May Gwangju uprising representation is also linked to this problem. Since the 1990s, the institutionalized and formalized language and imagination have been lethargy. This is also a matter of foundation and field sharing the same language. This article attempted to assess the present and tasks of the May Gwangju uprising narrative by reading the movie < Kim-Gun > (2018) and Choi Yoon's novel(1988).

파종시기별 유효적산온도(GDD)가 옥수수의 생육 및 수량변화에 미치는 영향

김미정,정건호,김성국,이재은,전원태,심강보,김민태,우관식,권영업,허성기,Kim, Mi Jung,Jung, Gun Ho,Kim, Sung Kook,Lee, Jae Eun,Jeon, Weon Tai,Shim, Kang Bo,Kim, Min Tai,Woo, Koan Sik,Kwon, Yong Up,Heu, Sunggi 한국작물학회 2017 한국작물학회지 Vol.62 No.3

A total of 15 different corn hybrids, Kwangpyeongok, Gangdaok, Yanganok, Singwangok, Jangdaok, Cheonganok, Cheongdaok, Andaok, Dapyeongok, Pyeongkangok, Pyeonganok, Daanok, Sunwon 184, Gangilok, and P3394 was used to investigate the growth and yield depending on the sowing date. The sowing dates were April 5, June 25, and July 5 and each experiments was performed in triplicste. The growth of Gangdaok was the highest. However, although the growth of Kwangpyeongok, was lower thanthar of Gangdaok, its stem height to ear height ratio was lower than that of Gangdaok, thus, Kwangpyeongok may be more suitable for stable cultivation. Both growth and yield of Daanok were low, regardless of planting date, but yield and ear shape of Pyeongkangok and Dapyeongok were for fresh corn. Growth and yield of the 15 different corn hybrids varied depending on the planting date, However, the growth degree days (GDD) was the most important factor governing the maturity of corn. More than $1500^{\circ}C$ of GDD was sufficient to harvest mature corn hybrids in the central region of Korea. Besides yield and growth, other characteristics, such as sweetness and taste of the hybrids, should be investigated further the selection of the best corn hybrid.

Pb(Mn_1/3Nb_2/3)O₃-PbZrO₃-PbTiO₃ 세라믹스의 압전특성에 미치는 Al₂O₃의 영향

김미정,김재창,김영민,어순철,김일호,Kim Mi-Jung,Kim Jae-Chang,Kim Young-Min,Ur Soon-Chul,Kim Il-Ho 한국재료학회 2005 한국재료학회지 Vol.15 No.7

Piezoelectric properties of $Pb(Mn_{1/3}Nb_{2/3})O_3-PbZrO_3-PbTiO_3$ ceramics were investigated with $Al_2O_3$ content $(0.0-1.0 wt\%)$. The constituent phases, microstructure, electromechanical coupling factor, dielectric constant, piezoelectric charge and voltage constants were analyzed. Diffraction peaks for (002) and (200) planes were identified by X-ray diffractometer for all the specimens doped with $Al_2O_3$, indicating the MPB (morphotropic phase boundary) composition of tetragonal structures. The highest sintered density of $7.8 g/cm^3$ was obtained for $0.2wt\%\;Al_2O_3-doped$ specimen. Grain size increased by doping $Al_2O_3$ up to $0.3 wt\%$, and it decreased by more doping. Electromechanical coupling factor, dielectric constant, piezoelectric charge and voltage constants increased by doping $Al_2O_3$ up to $0.2wt\%$, and it decreased by more doping. This might result from the formation of oxygen vacancies due to defects in $O^{2-}$ ion sites and the substitution of $Al^{3+}$ ions.

로지스틱 회귀모형을 이용한 유족연금 수급 분석

김미정,김진형,Kim, Mi-Jung,Kim, Jin-Hyung 한국통계학회 2008 응용통계연구 Vol.21 No.2

국민연금의 효율적인 운영을 위하여 고령화, 저출산과 같은 사회현상에 대비한 연금 관리를 위한 연구가 요구되고 있다. 본 연구는 유족연금의 발생을 예측하고 유족연금의 발생가능성 정도에 따라 대상자들을 분류하기 위한 통계적 모델을 제안하기 위하여 두 단계의 로지스틱 분석을 실시하였다. 첫 단계의 분석으로부터, 전체 대상자에 대하여 유족연금의 발생에 영향을 주는 주요인의 특성과 국민연금의 종류를 파악하고 이를 대상으로 유족연금의 발생에 대한 로지스틱 회귀모형을 적용하되 대상자를 합리적으로 등급화하기 위한 모델을 제안하고 이를 일반적인 로지스틱모델과 비교하였다. 정확도, 민감도, 특이도와 사후 확률의 분포를 비교하고 K-S통계량을 통하여 등급의 타당성 평가와 리프트 그래프를 통한 모델의 예측력평가를 함으로써 합리적 등급분류를 통한 대상자관리가 가능한 통계적 모델임을 보였다. 예측된 통계적 모델을 적용하여 유족연금 수급유무와 등급별 분류, 등급에 따른 유족연금액 예측을 통하여 효율적인 연금관리 방안을 제안할 수 있다. Research for efficient management of the National Pension has been emphasized as the current society trends toward aging and low birth rate. In this article, we suggest a statistical model for effective classification and prediction of the reserve for the survivor's pension in Korea. Logistic regression model is incorporated; correct classification rate, and distribution of the posterior probability for the reserve of survivor's pension are investigated and compared with the results from the general logistic models. Assessment of predictive model is also done with lift graph, ROC curve and K-S statistic. We suggest strategies for reducing financial risks in managing and planning the pension as an application of the suggested model.

품종별 무궁화 분말의 항산화활성 및 품질특성

김미정,진소연,Kim, Mi-Jung,Jin, So-Yeon 한국식생활문화학회 2017 韓國食生活文化學會誌 Vol.32 No.4

The aim of this study was to analyze the functional components of five cultivars of 'Mugunghwa (Hibiscus syriacus L.)' for the development of 'Mugunghwa'-added foods. There were five varieties, namely, Hibiscus syriacus 'Hwanhee' (HH), Hibiscus syriacus 'Samchulli' (SC), Hibiscus syriacus 'Harmony' (HM), Hibiscus syriacus 'Baekgu' (BG), and Hibiscus sabdariffa L (HB). Of the five varieties tested, HH extract showed the highest total phenolic content (131.85 GAE mg/g), DPPH free radical scavenging activity (95.18%), and anthocyanin and sugar contents. The sensory quality of powders from each Hibiscus variety was evaluated, and it was found that overall palatability decreased in the order: HH, SC, HB, HM, and BG. Thus, addition of Hibiscus variety, which has excellent functionality and palatability, to foods confers an extra element of Korean history and culture, which is expected to improve the marketability of various food products.

Properties of Alkaline Protease Isolated from Nocardiopsis dassonvillei

김미정,정혜신,박순재,Kim, Mi-Jung,Chung, Hye-Shin,Park, Soon-Jae 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.1

ATCC 21944인 노카디옵시스 다손빌레이 균주로부터 새로운 알칼리언 단백질분해효소를 분리하였다. 크로마토그래피 방법과 이온교환 HPLC를 사용하여 분리한 효소는 SDS-전기영동 젤상에서 순수한 것으로 나타났으며, 겉보기 분자량은 33,500 달톤인 것으로 나타났다. 이 효소의 pI는 6.3는 부근으로 나타났으며 효소의 활성은 PMSF 및 chymostatin과 같은 Serine 단백질 분해효소의 억제제들에 의해 영향을 받는 것으로 밝혀졌다. 온도에 따른 효소활성 실험결과 $55^{\circ}C$에서 활성이 가장 크며 $65^{\circ}C$까지는 최대 활성의 70%를 유지하며 또한 pH 11에서도 활성을 계속 유지하는 것으로 보여졌다. 분리된 단백질분해효소는 높은 온도에서 그리고 강한 알칼리성에서도 활성을 유지하므로 산업적으로 이용할 가치를 포함하고 있는 것으로 사료된다. We have purified a novel alkaline protease from actinomycete Nocardiopsis dassonvillei, ATCC 21944, using conventional chromatographic methods and an ion-exchange HPLC at the final stage. SDS-PAGE of purified enzyme showed that the enzyme is homogeneous, and the apparent molecular weight is 33,500 daltons. Isoelectricfocusing indicates its pI is around 6.3. The enzyme is inhibited by serine protease inhibitors such as phenylmethylsulfonyl fluoride and chymostatin. Temperature-dependent activity profile of the protease indicates that it is thermally stable and retains 70% of the activity at $65^{\circ}C$ compared to the maximum activity shown at $55^{\circ}C$. It also appears to be highly alkalophilic, maintaining almost full activity at pH 11.

노카디옵시스 다손빌레이 ( Nocardiopsis dassonvillei ) 로 부터 분리한 알칼라인 단백질분해 효소의 성질

김미정,정혜신,박순재 ( Mi Jung Kim,Hye Shin Chung,Soon Jae Park ) 생화학분자생물학회 1993 BMB Reports Vol.26 No.1

We have purified a novel alkaline protease from actinomycete Nocardiopsis dassonvillei, ATCC 21944, using conventional chromatographic methods and an ion-exchange HPLC at the final stage. SDS-PAGE of purified enzyme showed that the enzyme is homogeneous, and the apparent molecular weight is 33,500 daltons. Isoelectricfocusing indicates its pI is around 6.3. The enzyme is inhibited by serine protease inhibitors such as phenylmethylsulfonyl fluoride and chymostatin. Temperature-dependent activity profile of the protease indicates that it is thermally stable and retains 70% of the activity at 65℃ compared to the maximum activity shown at 55℃. It also appears to be highly alkalophilic, maintaining almost full activity at pH 11.

소아 아토피 피부염에 대한 문헌적 고찰(최근 중의잡지를 중심으로)

김미정,이승연,Kim Mi-Jung,Lee Seung-Yeon 대한한방소아과학회 2000 대한한방소아과학회지 Vol.14 No.2

A literature study was progressed for oriental medical treatment for atopic dermatitis. Atopic dermatitis is a chronic or chronically relapsing, pruritic dermatitis. In oriental medical treatment is classified into the treatment of inside(herb tea), treatment of outside(medicine for external application), treatment of inside & outside. The method of inside treatment is improving in health for the spleen and clearing wetness(健脾利濕), extinguishing wind and refreshing fever(消風淸熱), nourishing blood and making dryness gloss(養血潤燥). The method of outside treatment is refreshing fever and removing wetness(淸熱燥濕), counteracting the poison and getting rid of itch(解毒止痒), removing the boil and forming proud flesh(消腫生肌). The method of inside & outside is improving in health for the spleen and clearing wetness(健脾利濕), refreshing fever and getting rid of itch(淸熱止痒). refreshing blood and extinguishing wind(凉血祛風).

2형 당뇨병환자의 만성 치주염 치은조직에서 골흡수 인자의 발현 양상 비교

김미정,류상호,박진우,서조영,이재목,Kim, Mi-Jung,Ryu, Sang-Ho,Park, Jin-Woo,Suh, Jo-Young,Lee, Jae-Mok 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

Purpose: The purposes of this study were to compare and quantify the expression of MMP-3, $PGE_2$ and IL-6 in the gingival tissues of patients with $type_2$ diabetes mellitus and healthy adults with chronic periodontitis. Material and methods: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient's systemic condition & clinical criteria of gingiva, each gingival sample was devided into three groups. Group 1(n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2(n=8) is inflamed gingiva from patients with chronic periodontitis. Group 3(n=8) is inflamed gingiva from patients with chronic periodontitis associated with type 2 DM. Tissue samples were prepared and analyzed by Westernblotting. The quantification of MMP-3, $PGE_2$ and IL-6 were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test. Results: 1. The expression levels of MMP-3 were shown highest in group 3 compared to group 1 and 2, and It showed increasing tendency in group 2 and 3. 2. The expressions of $PGE_2$ and IL-6 were shown increasing tendency in group 2 and 3, and It was highest in group 3. 3. As expressions of MMP-3 were increased, $PGE_2$ and IL-6 expressions showed increasing tendency in group 3 than group1 and 2, although there were no proportional relationship. Conclusion: This study demonstrated that the expression levels of MMP-3, $PGE_2$ and IL-6 will be inflammatory markers of periodonta linflamed tissue and DM. It can be assumed that MMP-3 affect to expressions of $PGE_2$ and IL-6 in progression of periodontal inflammation with alveolar bone resorption to type 2 DM.