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흰쥐 이자에서 Nitric Oxide ( NO )가 Insulin분비에 미치는 영향
김명준,조양혁,성종호 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4
Background: NO (nitric oxide), derived from L-arginine through the action of nitric oxide synthase (NOS), is a short-lived free radical transmitting cellular signals for vasodilation, neurotransmission, and cytotoxicity. Recently, this molecule has been reported to be involved in the various glandular secretion. Although the relationship between NO and the pancreatic endocrine secretion has been widely investigated, the role of NO on insulin secretion has not been elucidated. Therefore, the present study was designed to reveal the precise action of NO on the secretion and synthesis of insulin following administration of NAME (L-NG -nitroarginine methyl ester) or L-arginine using immunocytochemistry and in situ hybridization techniques. Methods: NAME or L-arginine was administered into jugular vein of the male Sprague-Dawley rat (180~200 g, b,w.) exhibiting normoglycemia (80~120mg/dL). Blood glucose concentrations were measured at intervals of 30 minutes for 2 hours after drug treatment. The pancreatic tissues were taken out at 30 and 90 minutes following drugs administration for insulin immunocytochemistry and in situ hybridization. Results: Both NAME and L-arginine treatments diminished blood glucose levels. The decrease of blood glucose level was more prominent in NAME-treated rats than that of L-arginine. Insulin immunoreactivity in drugs-treated rat pancreas decreased compared to that in normal control, while the expression of insulin mRNA was significantly increased. Conclusion: On the basis of present study, it is concluded that the transient changes of NO con- centration, regardless of increase or decrease, in Langerhans islet might act as a potent stimulant in insulin secretion and its synthesis (J Kor Soc Endocrinol 14:719-72S, 1999).
김명준 한국고시가문학회 2005 한국시가문화연구 Vol.0 No.15
Until now in the history of researches, <Ganghosasiga(江湖四時歌)> was conclusively considered as a work of Maeng Sa Sung in his later years; therefore the awareness this work intends to implicate was viewed as the product of a harmonized and leisurely world view, whether it is the result of actual experiences or notion from Nacherleben. However, there is no definite evidence to prove that <Ganghosasiga> is a work of Maeng Sa Sung's later years, and as a matter of fact, there is a stronger possibility of <Ganghosasiga> being written in Maeng Sa Sung's youthful days when he was suffering from frustration. Moreover, different point of views can give lead to divergent interpretations of the world reflected in this work; therefore, this became the initiative of my argument. The fact that <Ganghosasiga> was published with works of Lee Saek and Jung Mong Joo in [Chunggooyoungeon] which included <Ganghosasiga> early, implies that [Chunggooyoungeon] projects three human types in a time of turning point through literary works. In addition, the period of actual experience of Gangho for Maeng Sa Sung during his life, that is, his retirement period in Asan, was the end of Koryo and beginning of Chosun Dynasty. In this period, the exile of his master Kwon Keun and banishment of himself also occurred. Just as Kwon Keun expressed his pain of frustration and volition of returning by writing the chapters of <Yeonjaroo> and <Poongyo>, Maeng Sa Sung has created another <Yeonjaroo> and <Ganghosasiga>, following his master. Therefore, the period <Ganghosasiga> was written can be estimated to be between the foundation of Chosun(1392) and his return to the government service(1394). As above, when we consider the period when <Ganghosasiga> was written in his banishment days, the world view of the work leaves a distance from optimism. To Maeng Sa Sung who seceded from the royal road of government service, the four seasons in Gangho would have been so painful. However, for he had heard the news of his master's return to the government in Gangho, Gangho can be regarded as the stage for his comeback. Maeng Sa Sung described Gangho, which enabled the hope of return despite the failures and ordeals, with aesthetics of duplex linguistics by 'nothing to do,'and 'grace of the great lord.' Conclusively, the world of <Ganghosasiga> would be a world where the actuality, which shows the reality of pain, and ideology which desires Nacherleben, meet in harmony.