우리나라 대학도서관 조직의 일 연구

김명옥,Kim, Myeong-Ok 한국도서관협회 1976 圖協月報 Vol.17 No.3

본고는 1975년도 9월 연세대학교 대학원 도서관학과 석사학위논문의 요약이다.

공수 예측 모델 요도를 위한 자료 흐름도의 실험적 평가

김명옥,백청호,양해술,Kim, Myeong-Ok,Baek, Cheong-Ho,Yang, Hae-Sul 한국정보처리학회 1995 정보처리논문지 Vol.2 No.1

소프트웨어 개발자와 사용자에게 직면한 가장 중요한 문제는 프로그래밍 시스템 의 크기와 개발 노력의 예측이라고 할 수 있다. 본 논문에서는 자료 흐름도, 자료 사 전, 소단위 명세서로 구성된 구조화 명세서에 관한 각각의 특성을 정의하고, 구조화 명세서의 정량적인 평가 요소를 프로그램 메트릭스에 적용하였다. 또한 구조화 명세 서를 구성하는 자료 흐름도에 관해서는 정량적인 평가 실험을 하였다. 그 결과 상위 공정의 분석 단계에서의 산출물에 의한 하위 공정에 관한 공수 예측 모델을 제안한다. One of the most important problems faced by software developers and users is the prediction of the size of programming system and its development effort. This article define the identical characteristics for structured specification which is consisted of Data Flow Diagram, Data Dictionary and Mini Specification and apply quantitative estimation factor of structured specification to program code metrics, Moreover, concerning DFD which is made up of component element of structured specification executed quantitative estimation experiment. In the result, we propose man/month prediction model of lower progression with production on analysis phase of upper progression.

고등학교 성지식에 관한 실태조사

김명옥,Kim, Myeong-Ok 한국지역사회간호학회 1990 지역사회간호학회지 Vol.2 No.1

Localization and Developmental Changes of Dopamine $D_1$ and $D_2$ Receptor mRNAs in the Rat Brain

김명옥,최완성,이봉희,조경재,서숙재,강성구,김경진,백상호,Kim, Myeong-Ok,Choi, Wan-Sung,Lee, Bong-Hee,Cho, Kyung-Jae,Seo, Sook-Jae,Kang, Sung-Goo,Kim, Kyung-Jin,Baik, Sang-Ho The Korean Society for Integrative Biology 1997 Korean journal of biological sciences Vol.1 No.3

Dopamine plays diverse roles in the fetal brain development and differentiation. However, the development of the dopaminergic neurons and its receptors has not been fully understood. In our studies, in situ hybridization and immunohistochemical methods were used to investigate the ontogeny of dopaminergic neurons and its receptor subtypes during the fetal development of the rat. In situ hybridization data showed that dopamine $D_1$ and $D_2$ receptor mRNAs were expressed in the ventricular and subventricular zones of ganglionic eminence, thalamus, hypothalamus, and cortical neuroepithelium on gestational day 13. Expression of dopamine $D_1$ and $D_2$ receptors during gestational days 17 and 19 reached the same or similar level of that in the adult brain. Expression of $D_1$ receptor mRNA preceded that of $D_2$ receptor mRNA in the early developmental stage, although this pattern was reversed with the sharp increase of $D_2$ receptor mRNA soon after. $D_2$ receptor mRNA was expressed in substantia nigra of mesencephalon of the fetal rat brain. However, $D_1$ receptor mRNA was not detected in substantia nigra. Our results indicate that dopamine might function in the fetal brain during the early gestational period.

동물 시의 관점 연구

김명옥(Myeong-Ok Kim) 한국외국어대학교 영미연구소 2011 영미연구 Vol.25 No.-

This article is to pursue the diverse perspectives of animal poems from the late 18th century to the 20th century. Some poets of the 18th century began to have an interest in nature, which appeared in their works as a main theme rather than as a background. In the 18th century nature meant beautiful landscapes chiefly of trees and flowers with animals excluded. But with man’s increasing awareness of the living beings in nature, the poets steadily began to write animal poems. The archtype of perspective on animals is God’s because when he made them first, he blessed with accepting them as independent living beings and taking care by feeding them. When from God’s perspective surveying the animal poems we have found two distinctive perspectives of the animal poets: the realistic description and the objective attitude toward animals. G. M. Hopkins, D. H. Lawrence and Marianne Moore and Ted Hughes share the realistic point-of-views by describing the biological and ecological traits on the basis of the keen observation, which proves their acceptance of animals as living independent beings. And in the objective perspective Moore is the most distinctive. Her view on the animals is nearest to God’s perspective in that she accepts the living animals as wonderful created beings with “grace” and “excellence”. On the other hand, the romantic poets, Keats and Shelly, show the most selfish perspective with trying to satisfy their private wishes through the birds. They failed in recognizing them as the independent identity by using them as symbolic emblems or abstracted images. Hopkins in his “The Windhover” shows the excellence in the realistic description on the flying hawk but his perspective has a limitation by replacing the mastery of the Hawk with that of Christ exposing his private faith. And Lawrence with Hughes reveals in their animal poems the man-centered perspective using animals as a medium to express their unique ideas furtively.

Differential Effects of Antipsychotic Drugs on Dopamine D1 and D2 Receptor mRNAs in the Rat Brain

김명옥(Myeong Ok Kim),김윤숙(Yoon Sook Kim),박창환(Chang Hwan Park),양영애(Young Ae Yang),강상수(Sang Soo Kang),조경제(Gyeong Jae Cho),노구섭(Gu Seob Roh),최완성(Wan Sung Choi) 대한해부학회 2005 Anatomy & Cell Biology Vol.38 No.4

본 연구는 흰쥐 뇌의 조가비핵 (CPu), 기댐핵 (NAc), 후각결절 (OTu) 부위에서 항정신병약물(antipsychotics)에 의한 도파민 D1, D2 수용체 mRNA 발현양상의 변화를 알아보고자 하였다. Sprague-Dawley계의 흰쥐를 대상으로 정상군은 물, 실험군은 물을 대신하여 haloperidol (1mg/mL), sulpiride (40 mg/mL), clozapine(20 mg/mL)을 4주 동안 지속적으로 공급하였다. 이러한 약물의 처리는 도파민 D1, D2 mRNA 유전자 발현에 있어서 다른 결과를 나타내었다. Haloperidol, sulpiride는 흰쥐 뇌의 CPu, NAc, OTu 부위에서 도파민 D1, D2 수용체 mRNA 발현 증가를 유발하였고, Haloperidol 처리군이 sulpiride 처리군 보다 도파민 D1, D2 수용체 mRNA 발현양상이 증가한 것으로 관찰되었다. 하지만, clozapin의 처리는 동일한 부위에서 도파민 수용체 mRNA 발현양상이 적었다. 항정신병약물의 처리는 흰쥐 뇌에서 도파민 D1, D2 수용체 mRNA 발현에 차이 있는 결과를 나타내었다. 이상의 결과로 항정신병약물 처리는 도파민 농도 변화에 부분적으로 관여하는 것으로 생각된다. The principal aim of this study was to determine the effects of antipsychotics (haloperidol, sulpiride, and clozapine) on regulating dopamine (DA) D1 and D2 receptor mRNA levels in the rat caudate putamen (CPu), nucleus accumbens (NAc), and olfactory tubercle (OTu). Twenty male Sprague-Dawley rats (250 g) were treated with haloperidol (1mg/mL), sulpiride (40 mg/mL), clozapine (20 mg/mL), and the control group received only water. Drugs were administered orally for 4 weeks. Antipsychotic drugs had differential effects on DA D1 and D2 receptor gene expression. Haloperidol and sulpiride induced an increase of DA D1 and D2 receptor mRNA levels in the rat CPu, OTu, and NAc; haloperidol caused a greater increase than sulpiride. However, clozapine treatment had less effect on DA receptor mRNAs levels in the same area. Antipsychotic drugs differentially upregulated the expression of DA D1 and D2 receptor mRNAs in the rat brain. These changes may be related, at least in part, to changes of DA concentration following antipsychotics treatment.

일부 흡연 남성의 식사섭취와 대사증후군 위험도

김명옥(Myeong Ok Kim),이혜진(Hye Jin Lee),박은주(Eun Ju Park),이경혜(Kyung Hea Lee) 대한지역사회영양학회 2010 대한지역사회영양학회지 Vol.15 No.6

This study was intended to investigate the risk of metabolic syndrome (MS) in healthy 92 male smokers (mean age: 44.4 ± 7.8 yrs). We investigated the anthropometric assessment and dietary intake survey for 2 days by 24-recall method, also blood pressure and serum lipids were measured. The average numbers of cigarettes smoking a day were 21.3/d, smoking duration were 21.5 years. The proportion of fat energy was 24.9% and intakes of vitamin B2, folate, calcium, potassum and fiber were lower than KDRI. The body mass index (BMI) and body fat % were 24.8, 23.9% respectively. The systolic (134.1 ± 1.4 mmHg) and the diastolic blood (87.9 ± 1.1 mmHg) pressure were in borderline hypertension. Among biochemical parameters, TG (173.6 ± 9.4 mg/dL) and fasting blood glucose (109.0 ± 2.4 mg/dL) levels were out of normal values. The most occurred problem among the risk factors related to MS was the borderline hypertension (63%) in subjects. Regarding the correlations of anthropometric data with biochemical factors, TG was significantly correlated with the BMI, body fat % and waist circumference. Smoking years showed positive correlation with AI. These results suggest that the smoking habit has significant relations with the risk factors of MS. Therefore, quitting is necessary to prevent MS, and nutrition education and dietary management program are required to prevent the degenerative disease. (Korean J Community Nutr 15(6): 783~795, 2010)

사람 태반에서 GnRH와 GnRH-receptor mRNAs의 발현

김명옥(Myeong Ok Kim),고필옥(Phil Ok Koh),조경제(Gyeong Jae Cho),김해석(Hae Suk Kim),이종학(Jong Hak Lee),김종화(Jong Hwa Kim),백원영(Won Young Paik),최완성(Wan Sung Choi) 대한체질인류학회 1998 해부·생물인류학 (Anat Biol Anthropol) Vol.11 No.1

본 연구는 사람 태반에서 GnRH 와 CnRH -receptor mRNAs 가 어느 세포에서 양현되는지 조사하고, 발현세포의 분포가 임신시기에 따라 어떻게 변화하는지를 조사하기 위하여 수행되었다. 임신중의 각 시기별 태반조직을 대상으로 GnRH 와 CnRH -receptor cDNA 에 대한 cRNA probe 흘 이용하여 tn Stf hybndlzation 을 시행 한 결과에서 다음과 갇은 소견을 얻었다. GnRH mRNA 는 모든 임신시기의 태반 조직내의 cytotrophoblasts, syncytiotrophoblasts, villous stromal cells 에서 동정되었다. GnRH mRNA signals 은 맡기로 갈수록 villous stromas 에서 강한 양성 반응이 관찰되었다. GnRH- receptor mRN A signals는 9-10주의 cytotrophoblasts 와 syncyhotrophoblasts 에서 강한 발현을 나타내었고 말기로 갈수록 감소되었다. GnRH 도 사람의 태반내에서 trophoblasts 에서 극소적 으로 생성되고, CnRH -receptor 는 GnRH 와 유사하게 태반융모의 trophoblast 에서 발현 된다. 또한, CnRB -receptor 가 임신유지에 필요한 융모악 성샘자극호르몬의 분비양상과 유사하게 생성되는 것으로 보아 GnRH 가 융오악 성생자극호르몬의 망성 벚 분비에 있어 조정인자로 작용할 가능성이 있있며, 그 작용에 있어 paracnne 또는 autocnne 역할을 항 것으로 생각된다.

발효 칠피의 생리활성 및 Hedgehog 신호기작과 싸이토카인에 의한 직장암 세포 증식 억제

김명옥(Myeong-ok Kim ),김연주(Younjoo Kim),김주성(Ju Sung Kim),허성일,김명조(Myong Jo Kim) 한국약용작물학회 2012 한국약용작물학회 학술대회논문집 Vol.2012 No.1

오이 균핵병에 대한 몇 가지 살균제의 방제 효과와 살균제에 대한 균핵병균의 감수성 정도 조사

김명옥(Myeong Ok Kim),민지영(Ji Young Min),최우봉(Woo Bong Choi),강범관(Beum Kwan Kang),박성우(Sung Woo Park),최경자(Gyung Ja Choi),박창식(Chang Sik Park),조광연(Kwang Yun Cho),김흥태(Heung Tae Kim) 한국농약과학회 2005 농약과학회지 Vol.9 No.4

As Sclerotinia sclerotiorum causing cucumber sclerotinia rot was the fastest in the mycelial growth at 25℃, its pathogenicity was strong at the same temperature among several temperatures. All the isolates of Sclerotinia sclerotiorum showed a strong pathogenicity against cucumber fruits, which was confirmed by a disk assay and a wound assay. A wound assay was superior to a disk assay to develop the assay system for assessing the fungicidal activity of several fungicides against Sclerotinia sclerotiorum. In a disk assay, it was very difficult to assess the fungicidal activity, because the pathogenicity of isolates used in the experiment was very strong. At 500 and 3.0 ㎍/mL, the activity of dichloflouanid and the mixture of carbendazim and diethofencarb against cucumber sclerotinia rot was 14.3 and 42.3%, respectively, by using a disk assay. However, at same concentration two fungicides showed the high controlling activity as 100 and 92.5%, through a wound assay in a laboratory. Also, the activity of two fungicides was good against cucumber sclerotinia rot in the greenhouse where cucumber plants were cultivated in the field, showing the control value as 91.1 and 82.9% at 100 and 825 ㎍/mL, respectively. All the isolates of Sclerotinia sclerotiorum from cucumber fruits sampled in the polyvinyl house were subjected to monitoring for the resistance to 7 fungicides. The EC?? value of 7 fungicides was as follows: fenhexamid; 0.13 ㎍/mL, procymidon and iprodione; 0.18 and 0.24 ㎍/mL, carbendazim and the mixture of carbendazim and diethofencarb; 0.13과 0.05 ㎍/mL, iminoctadine and dichlofluanid; 1.94 and 8.95 ㎍/mL. Ultimately it was not found that resistant isolates of Sclerotinia sclerotiorum were appeared in the field.