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김덕환,김교준,조성환,전무형,권오덕,배규열,이영순,Kim Duck-Hwan,Kim Kyo-Joon,Cho Sung-Whan,Jun Moo-Hyung,Kwon Oh-Deog,Bae Kyu-Yul,Lee Yong-Sun 한국임상수의학회 1986 한국임상수의학회지 Vol.3 No.2
One six-year-old male Cocker spaniel with chief complaints of mandibular swelling and anorexia was referred. This dog was diagnosed into lymphosarcoma by the results of the examination with peripheral blood and fluid of the lymph nodes and bone marrow aspirated. This patient was multicentric form clinically and was cytomorphologically identified into lymphoblastic form of lymphosarcoma.
조성환,김덕환,김교준,권오덕,박노태,Cho, Sung Whan,Kim, Duck Hwan,Kim, Kyo Joon,Kwon, Oh Deog,Park, No Tai 충남대학교 농업과학연구소 1986 Korean Journal of Agricultural Science Vol.13 No.2
식욕부진(食慾不振) 및 복부팽만(腹部膨滿)을 충남대학교(忠南大學校) 농과대학부속가축병원(農科大學部屬家畜病院)에 의뢰(依賴)된 11년(年)된 암컷 잡종견(雜種犬)을 병리조직학적(病理組織學的)으로 관찰(觀察)한 바 담관세포암으로 진단(診斷)하였고 그 결과(結果)는 다음과 같다. 임상적(臨床的) 소견(所見)으로 복부팽만(腹部膨滿), 식욕부진(食慾不振), 호흡곤란(呼吸困難), 및 침울(沈鬱) 등(等)을 관찰(觀察)할 수 있었고, 혈중(血中) GOT, GPT, LDH 및 BUN등(等)은 정상치(正常値)보다 증가(增加)하였으며 총단백량 및 Albumin 은 약간 감소(減少)하였다. 육안적(肉眼的) 소견(所見)으로 간장(肝臟)은 종대, 표면(表面)에는 많은 백색(白色)의 꽃양배추양 결절(結節)이 있었으며 직경(直徑) 3~4cm의 낭형성(囊形成)이 있었다. 낭내(囊內)에는 황백색(黃白色)의 교상물질(膠狀物質)이 차 있었다. 해부학적(解剖學的)으로 본종양을 간내(肝內) 담관암으로 분류(分類)하였다. 조직학적(組織學的)으로 본종양은 관상암과 담관낭종암이 혼합(混合)되어 있었으며 관상암은 관상구조(管狀構造)가 특징(特徵)으로 내피세포(內皮細胞)는 입방형(立方形) 또는 원계형(圓桂形)이며 결합조직(結合組織)의 증식(增殖)을 볼 수 있었다. 그리고 담관낭종암은 단층(單層)및 중층입방형(中層立方形) 또는 국주형세포(國柱形細胞)로 덮혀 있었다. On 11-year-old female mixed-breed dog with chief complaints of existence of abdominal enlargement and anorexia was referred to the veterynary teaching hospital of Chungnam National University. The dog was diagnosed into cholangiocarcinoma by the result of the histopathological observation. The results observed are summarized as follows: The clinical signs were abdominal enlargement, anorexia, dyspnea and depression. There were marked increase in serum glutamic pyruvic transaminase(GPT), serum glutamic oxaloacetic transaminase(GOT), lactic dehydrogenase(LDH) and blood urea nitrogen(BUN). Serum total protein and albumin were slightly below normal. In gross finding, the liver was enlarged and friable with numerous white, cauliflower-like nodules over the surface and composed on cysts from 3 to 4 cm in diameter. The cystic lesions contained a yellow gelatinous material. Anatomically, this neoplasm was classified as intrahepatic bile duct carcinoma. Histologically, this neoplasm was combined tubular carcinoma with bile duct cystadenocarcinoma. The former were characterized by tubular structures lined by anaplastic cuboidal or columnar cells with diffuse fibrous stroma, and the latter by multiple cystic structures lined by simple and stratified cuboidal or columnar cells.
섬유성 이형성증 및 골섬유성 이형성증에서의 c-fos 단백 발현
박혜림,박용구,김덕환,Park, Hye-Rim,Park, Yong-Koo,Kim, Duck-Whan 대한근골격종양학회 1999 대한골관절종양학회지 Vol.5 No.4
The purpose of this study was to evaluate the role of c-fos oncogenes in the development of fibrous dysplasia and osteofibrous dysplasia. The immunohistochemical expression of c-fos protein was evaluated in 15 cases of fibrous dysplasia and 8 cases of osteofibrous dysplasia. Ten cases of fibrous dysplasia were weakly positive with c-fos. Six cases of osteofibrous dysplasia were weakly positive and the remaining two cases were strongly positive. The overall expression of c-fos protein is weaker than high-grade osteosarcoma, thus the implication of c-fos protein is little in the development of these tumors. Fibrous dysplasia and osteofibrous dysplasia share some features of characteristic histology and c-fos expression.
노견(老犬)에 발생(發生)한 질섬유종(膣纖維腫)의 외과수술(外科手術) 1예(例)
김명철,김교준,김덕환,조성환,권오덕,Kim, Myung Cheol,Kim, Kyo Joon,Kim, Duck Hwan,Cho, Sung Whan,Kwon, Oh Deok 충남대학교 농업과학연구소 1987 Korean Journal of Agricultural Science Vol.14 No.2
질내(膣內)에 발생(發生)한 종양(腫瘍)으로 인하여 내원(來院)한 13년생(年生) terrier견(犬)에 대하여 회음부(會陰部)를 통한 종탕절제술(腫蕩切除術)을 실시(實施)한 증례(症例)를 보고(報告)한다. 1. 조직학적(組織學的)으로 관찰(觀察)한 결과 섬유종(纖維腫)으로 인정(認定)되었다. 2. 외음순(外陰脣)의 배측연접(背側連接) 상부(上部)의 1cm 폭(幅)을 남겨놓고 질부(膣部)의 배벽(背壁)까지 피부(皮膚) 및 근층(筋層)을 절개(切開)한 후절개창공(後切開創孔)을 통하여 종양물(腫瘍物)들을 절제(切除)한 결과(結果) 외음부(外陰部)의 형태에 변화(變化)를 일으키지 않고 원상(原狀)을 유지(維持)하였다. 3. 절제후(切除後) 현재(現在)까지 (약(約)6개월(個月)) 재발미후(再發微候)는 인정(認定)되지 않았다. A 13 years old terrior dog with vaginal tumor was referred to the animal hospital of Chungnam National University. Resection of vaginal tumor through perineal area was performed. The results obtained were as follows. 1. Histologically, tumor was classified with fibroma. 2. The skin and musculature of the perineal area was incised to the dorsal area of the vaginal wall except I em of width over the dorsal commissure of the vulvar cleft. Through the opening of the wound, pedunculated tumors were amputated and diffused tumors were removed by submucosal resection. After the surgical operation, the original shape of the external area of vulva was not changed. 3. After the resection recurrent sign was not observed up to nowadays for about 6 months.
깊은 구멍 가공을 위한 가공액 초음파 가진 미세 방전가공
제성욱(Sung Uk Je),김덕환(Duck Whan Kim),이해성(Hae Sung Lee),주종남(Chong Nam Chu) Korean Society for Precision Engineering 2005 한국정밀공학회지 Vol.22 No.7
Microholes with high aspect ratio are required in microstructures. Among various methods for producing the microhole, micro electrical discharge machining (MEDM) is very effective and useful process. But, it is difficult to machine the high aspect ratio holes below 100 ㎛ in diameter because machining condition becomes unstable due to bad removal of debris at deep hole. In this paper, ultrasonic vibration is applied to MEDM work fluid to make a high aspect ratio micro hole. It is shown that the vibration is effective in circulating the debris and increasing the machining rate. As a result, produced was a micro hole with 92 ㎛ entrance diameter, 81 ㎛ exit diameter and aspect ratio 23.
이수진,이재일,김명철,홍성혁,김덕환,조성환,Lee, Soo-jin,Lee, Jae-il,Kim, Myung-cheol,Hong, Sung-hyuk,Kim, Duck-hwan,Cho, Sung-whan 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.3
This study was performed to determine the optimal dose of ozone for wound healing. Twenty Korean black goats were allocated to 4 groups. The skin wound with $1{\times}1cm$ was induced over the hoof. For 5 minutes per day, 0.1 ppm (Group I), 1 ppm (Group II) and 6 ppm (Group III) ozone gas was applied. In control group, 5 ml of normal saline was applied daily on the wound. Wound square was determined using color image analyzer at day 0, 4 and 14. Soft tissue depth of wound was determined using radiograph. Before the application of ozone gas, $1{\times}1cm$ of skin tissue was resected and observed for histopathologic findings. To determine the healing effect, $2{\times}1cm$ of wound tissue was resected and observed for histopathologic findings at day 14. In mean squares of wound, all experimental groups revealed more reduced mean squares than control group at day 4, and especially Group II (p<0.05) and Group III (p<0.05) revealed significant reduction. At day 14, Group I and Group II (p<0.05) revealed more reduced mean squares than control group, but Group III revealed less reduced mean squares than control group. In soft tissue depth of wound, all experimental groups and control group revealed swelling at day 4, compared with day 0. At day 14, all experimental groups and control group revealed reduction, compared with day 4, and especially Group II (p<0.05) revealed significant reduction. In histopathological findings, inflammation findings in epidermis and dermis, hemorrhagic finding in epidermis were revealed in control group. In Group I, inflammation finding was reduced, compared with control group. Formation of scab and many reepithelialization of epidermis were revealed. In Group II, inflammation findings in epidermis and dermis which were observed in control group were not found, normal skin tissue was revealed. In Group III, inflammation findings in epidermis and dermis were revealed, reepithelialization of epidermis was not founded. Slow healing process was observed, compared with Group I and II. It was concluded that Group II has excellent promotion effect of wound healing.