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Effects of Raphani Semen Ethanol Extracts on Skin Inflammation in HaCaT Keratinocytes
김근립,홍철희,이규영 대한한방안이비인후피부과학회 2022 한방안이비인후피부과학회지 Vol.35 No.2
목적 : 본 연구는 인간피부각질형성세포(HaCaT keratinocytes) 모델을 TNF-α와 IFN-γ로 자극하여 萊菔子의 피부염증 감소및 만성 염증성 질환에 미치는 영향을 알아보고자 하였다. 방법 : 萊菔子 에탄올 추출물(RSE)이 세포생존율에 미치는 영향을 확인하기 위하여 MTT assay를 시행하였다. 또한 RSE가 TNF-α와 IFN-γ로 자극한 HaCaT 세포에서 p-IκBα, p-ERK, p-JAK2, p-STAT1, p-STAT6의 발현과 periostin, TSLP 단백질 발현에 미치는 영향을 확인하였다. 결과 : RSE는 200㎍/㎖ 이하에서 세포 독성을 보이지 않았고, HaCaT keratinocytes에서 TNF-α와 IFN-γ자극에 의하여 증가된 IκBα, ERK의 인산화를 억제하였다. 또한 JAK2와 STAT1, STAT6의 인산화를 억제하였으며, periostin과 TSLP의 발현을 감소시켰다. 결론 : RSE는 HaCaT keratinocytes에서 pro-inflammatory cytokines 및 transcription factors의 발현을 감소시켜 피부 염증 감소 효능을 보였고, 만성 염증성 질환에서 萊菔子의 사용 가능성을 확인하였다.
양성 발작성 자세변환성 현훈에 대한 반하백출천마탕(半夏白朮天麻湯)의 효과: 체계적 문헌고찰과 메타분석
김근립,홍철희,이규영,Kim, Geun-Lip,Hong, Chul-Hee,Lee, Kyou-Young 대한한방안이비인후피부과학회 2021 한방안이비인후피부과학회지 Vol.34 No.4
Objectives : The purpose of this study is to evaluate the effect of Banhabaeckchulchunm a-tang(BBCT) for Benign Paroxysmal Positional Vertigo(BPPV) Methods : We searched randomized controlled trials(RCTs) which assess the effect of BB CT for BPPV through 8 electronic databases from their inception to July 2021. RevMan 5.4 was used to evaluate the risk of bias. Results : 12 RCTs with 901 subjects were included. The BBCT treatment group had significantly higher total effetive rate(TER) than the western medicine treatment group(P=0.0001), and the Dizziness Handicap Inventory(DHI) score(P=0.003), traditional chinese medicine syndrome(TCM syn.) score(P<0.00001), and Visual analog scale(VAS)(P=0.0006) were significantly lower than the western medicine treatment group. The combined treatment of BBCT and canalith repositioning procedure(CRP) group had significantly higher TER than only CRP treatment group(P=0.02), and there was no significant difference in DHI score(P=0.12). TG(P=0.006) and TC(P=0.04) were significantly lower, and ApoA1 was significantly higher(P=0.0001). There was no significant difference in LDL(P=0.24). Conclusions : These results demonstrate that BBCT could be effective for BPPV especially after CRP. However, because of limits of included studies such as high heterogeneity between the literatures, unclear risk of bias, insufficient reports of adverse events(AEs), a well-designed RCTs with a low risk of bias in more diverse countries are needed in the future.
김근립,이규영,홍철희 대한한방안이비인후피부과학회 2020 한방안이비인후피부과학회지 Vol.33 No.2
Objectives : The purpose of this study is to report the effectiveness of using korean medical treatment on ulcer occurred in Anus and Vulva. Methods : We treated the patient with Taglisodog-eum(托裏消毒飮), acupuncture, and korean medical treatment using herb such as ointment and fumigation therapy. VAS score, Photographs were used to evaluate the effects of treatment. Results : After the total treatments, VAS score decreased from 7 to 1. In this case, we treated ulcer and checked regeneration of new tissue. Conclusions : The result suggests that Korean medical treatment including Taglisodog-eum(托裏消毒飮) can be effective in treatingulcer.
김근립,홍철희,이규영,Kim, Geun-Lip,Hong, Chul-Hee,Lee, Kyou-Young 대한한방안이비인후피부과학회 2021 한방안이비인후피부과학회지 Vol.34 No.1
Objectives : The purpose of this study is to report the effectiveness of Korean medical treatment on ptosis in myasthenia gravis. Methods : We treated the patient who had suffered from rt. ptosis and was diagnosed with myasthenia gravis with acupuncture, electropuncture, herbal acupuncture, cupping therapy, herbal medicines and western medicine such as corticosteroids and acetylcholinesterase inhibitors. The effectiveness of treatment was evaluated through Relative Interpalpebral Fissure(IPF) and photography. Results : After the treatments, relative Interpalpebral Fissure(IPF) was increased and improvement remained for three months after the treatment was finished. Conclusions : The result indicates that combination therapy of Korean medical treatment and western medicine had an effect on treatment of ptosis with myasthenia gravis.
山白菊 열수추출물이 HaCaT 피부각질세포에서 미치는 항염증 효과
김세중,이규영,김근립,홍철희 대한한방안이비인후피부과학회 2022 한방안이비인후피부과학회지 Vol.35 No.2
Objectives : This study was conducted to verify the anti-inflammatory effects of Aster glehni water extracts in HaCaT keratinocytes. Methods : In this study, cell viability was confirmed by MTT assay. Production of TNF-α and IL-6 was determined by ELISA. mRNA expression of TARC and MDC were measusred by qRT-PCR. Also, expressions of p-JNK, JNK, p-ERK, ERK, p-p38, and p-38 were investigated by using western blot assay. Results : Aster glehni water extracts were not shown any significant cytotoxicity at 15.625-500㎍/㎖ in HaCaT keratinocytes. Aster glehni extracts inhibited the TNF-α and IL-6 production in HaCaT keratinocytes treated with TNF-α and IFN-γ. Also, expression of TARC, MDC, p-ERK, and p-STAT1 was decreased. Conclusions : These results suggest that Aster glehni water extracts have anti-inflammatory effects in HaCaT keratinocytes and can be applied to the development of anti-inflammatory treatment substances.