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김규언 대한의진균학회 2001 대한의진균학회지 Vol.6 No.1
The number of fungus spores in the air is greater compared to that of pollen and also is less influenced by season. Recently there is increasing interest in the role of fungus as an allergen and causative factor of sick building syndrome. There are several kinds of samplers for the collection of fungus spore in outdoor and/or indoor air such as Durham sampler, rotorod sampler, personal volumetric air sampler, seven-day recording volumetric spore trap, and portable air sampler for agar plates. Because personal volumetric air sampler is small, rechargeable and volumetric equipment it is suitable for air sampling indoors. Portable air sampler for agar plates is useful for fungus culture from indoor and outdoor air. According to the result of our study on distribution of fungus spores in indoor and outdoor air by using personal volumetic air sampler, Cladosporium and Leptosphaeria were common spores in indoor and outdoor air. The number of spores in indoor air was closely correlated with that in outdoor air. Therefore it would be necessary to establish a standard method for collecting the fungus spores. We need to perform the nationwide study on distribution of fungus spores using this method, and to evaluate the allergenicity of fungus spores. [Kor J Med Mycol 6(1): 9-16]
소아 천식환아에 대한 기관지확장제 투여시험의 진단적 가치평가
김규언,이기영,정병주 대한천식알레르기학회 1990 천식 및 알레르기 Vol.10 No.3
To evaluate the diagnostic value of bronchodilator response, 146 childhood asthmatic patients at the Pediatric Allergy Clinic of Yonsei University College of Medicine with symptoms were randomly given the following bronchodilators .' 1: 1000 epinephrine(76 cases), clenbuterol syrup (36 cases), fenoterol aerosol(18 cases), hexoprenaline aerosol(8 cases) and terbutaline syrup(8 cases). The pulmonary function(peak expiratory flow rate '. PEFR) was measured by Wrights peak expiratory flow meter before and after the administration of bronchodilators and positive reaction was defined by a 15% improvement in PEFR over the base-line PEFR after bronchodilator administration. The following results were obtained: l. Of the 146 asthmatic patients, 114 cases reacted positively to bronchodilator administration showing a 78.4% positive rate. For each bronchodilator, the positive rates were 77 6% for epinephrine, 77.8% for clenbuterol, 75.0% for terbutaline, 77.7% for fenoterol and 87.5% for hexoprenaline respectively. 2. 86.8% of total cases reacted to the administration of bronchodilators within 15 minutes. For epinephrine, fenoterol, and hexoprenaline,positive reactions occurred within 15 minutes of administration of the drugs, But only 60.7% of those treated with clenbuterol and 33.3% with terbutaline showed a positive reaction at 15 minutes. 3. The positive rates were high for patients with low base-lines(%PEFR): 93.1% of patients with a base-line below 50% and 87.9% with a 51-6 5% base-line showed a positive reaction compared to a 58.1% for a 66-85% base-line and 54.2% for those above a 86% base-line. 4. Moderate or marked impovement occurred in 90.8% and 72.4% of patients with less than a 65% base-line %PEFR. But 48.4% of patients with an above 66% base-line %PEFR showed only mild improvement. The advantage of using a bronchodilator response is that diagnosis and treatment for asthma can be carried out simultaneously. However, negative results might be obtained in cases of mild bronchoconstriction. Therefore, in cases where the base-line of pulmonary function is greater than 85% of the normal predictive value, it might be appropriate not to carry out the bronchodilator test.