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당뇨병 환자의 자율신경병증 평가에 있어 24 시간 Holter Monitoring 을 이용한 Power Spectrum 의 Diurnal Variation 에 대한 연구
박순희(Sun Hee Park),박종욱(Chong Wook Park),김정식(Jeong Sik Kim),곽현철(Hyun Cheol Kwak),김광석(Kwang Suck Kim),오성주,김수길,원동준(Dong Jun Won),박정식(Jeong Sik Park) 대한내과학회 1997 대한내과학회지 Vol.53 No.4
N/A Objective: We studied the efficacy of the power spectral and nonspectral analysis and its diurnal variations for the early detection of the diabetic autonomic neuropathy. Method: The spectral and nonspectral analysis of 24hour-Holter monitoring were done for both diabetic neuropathy patients and controls. We also made a comparative analysis of the diurnal variations between the patient and control groups by means of hourly power spectral analysis. Result: 1) The power spectral density of the diabetic neuropathy patients was below than that of the normal controls (P<0.05) (Table 2, Fig. 1). 2) The nonspectral analysis of the diabetic neuropathy patients was below than that of the normal controls except for the mean RR intervals (P<0.05) (Table 3). 3) Every hour-power spectral analysis showed a diurnal variation of day time (06:00 to 16:00) decrease in high frequency area of the normal controls. On the contrary, there was a disappearance of the diurnal variation in patient group. Conclusion: The power spectral and nonspectral analyses after 24hour-Holter monitoring and its diurnal variation in the diabetic patients are considered as good means of the early detection of autonomic neuropathy, but further study of its diagnostic value will be needed.