IWA DipCon 2003 학술대회 참가기

김건하 대한토목학회 2003 대한토목학회지 Vol.51 No.9

Neuroprotective Effect of Lacosamide on Hypoxic-Ischemic Brain Injury in Neonatal Rats

김건하,변정혜,은백린 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.2

Background and Purpose Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of sodium channels and modulates collapsin response mediator protein-2. LCM was recently demonstrated to exert a neuroprotective effect in a murine model of trau¬matic brain injury and status epilepticus. Assuming the same underlying excitotoxicity-related brain injury mechanism, we hypothesized that LCM would have a neuroprotective effect in hypoxic-ischemic brain injury. Methods We divided rats into three groups at each testing session: pre- or postfed with LCM, fed with normal saline, and sham. A hypoxic-ischemic brain injury was induced by subjecting 7-day-old rats to right carotid artery coagulation followed by 2.5 h of exposure to 8% oxygen. The animals were killed on postnatal day 12 to evaluate the severity of brain damage. Open field testing was also performed between week 2 and week 6, and the Morris water maze test was performed in week 7 after hypoxia-ischemia. Results The incidence of liquefactive cerebral infarction was lower in rats prefed with LCM at 100 mg/kg/dose, with the mortality rate being higher at higher doses (200 and 300 mg/kg/dose). The infarct areas were smaller in LCM-prefed rats in several brain regions including the hemisphere, hippocampus, cortex, and striatum. Spatial learning and memory function were better in LCM-prefed rats (p<0.05). No effect was observed in postfed rats. Conclusions This study suggests that LCM pretreatment exerts a neuroprotective effect on hypoxia-ischemia in neonatal rats. The obtained results suggest that LCM pretreatment could be used as an effective neuroprotective method for neonates under hypoxic-ischemic condi¬tions including heart surgery.

물환경분야 남북한 협력방안

김건하 대한상하수도학회 2020 상하수도학회지 Vol.34 No.1

With growing expectations for economic cooperation between the two Koreas, there is much interest in participating in the construction of infrastructure in North Korea. In particular, water and wastewater infrastructure is the four major social infrastructures in addition to housing, transportation, electricity and telecommunications. North Korea is known to have severe water pollution and ecosystem destruction in major rivers, water pollution and soil pollution in mining areas are serious, and water and sewage infrastructures in cities other than Pyongyang are known to be weak. Preemptive investment in water supply and drainage in North Korea is the foundation for securing the quality of life of the North Korean people and is the foundation of public health and industry. It is a leading investment to reduce the cost of unification and is a new growth engine for the construction industry. In this study, we proposed a plan to exchange and cooperate in water environment for building water infrastructure of North Korea by examining the data related to water quality, water resources, water disaster, related legal system and manpower exchange situation in North Korea.

하천・호소 질소, 인 존재형태 및 피복을 이용한 수질영향 저감

김건하 한국퇴적환경준설학회(구 한국환경준설학회) 2014 한국환경준설학회 학술대회논문집 Vol.2014 No.-

Development and Application of Total Coliform Load Duration Curve for the Geum River, Korea

김건하,윤재영 대한토목학회 2011 KSCE JOURNAL OF CIVIL ENGINEERING Vol.15 No.2

The load duration curve methodology was developed as a useful protocol to estimate the exceedence probability of pollutant loading to a river. The technique was applied to estimate the Total Coliform (TC) loading to a monitoring location in the Geum River,Korea. The daily mean flow rate and TC concentration data from January, 1996 to July, 2004 from a monitoring station in Gongju were used. A procedure to construct flow and load duration curves for the TC loading for Gongju is presented. A standard duration curve reflecting the water quality criteria was constructed to determine water quality compliance. A comparison of the load duration curve with the standard duration curve for Gongju revealed that the water quality did not meet the desired water quality for about 47% of the exceedance probability. From the analysis of the TC load duration curve and standard load duration curve, it could be inferred that diffuse pollution was mainly responsible for the water quality degradation at Gongju.

천식 환아에서 메타콜린 기관지 과민성의 추적 관찰

김건하,서강진,변정혜,송대진,유영,정지태,고영률 대한 소아알레르기 호흡기학회 2007 Allergy Asthma & Respiratory Disease Vol.17 No.3

Purpose : The aim of this study was to investigate changes in bronchial hyperresponsiveness, total IgE, blood total eosinophil counts and serum eosinophil cationic protein (ECP), after treatment with inhaled corticosteroids or leukotriene modifiers in children with asthma. Methods : Methacholine bronchoprovocation tests were repeated at 12 months of follow-up in 37 children with atopic asthma and eight children with non-atopic asthma, who regularly attended the Allergy Clinic of Korea University Anam Hospital and Seoul National University Hospital over one year from their initial visit. A serum total IgE, peripheral blood eosinophil counts, and serum ECP levels were measured on their initial visits and at 12 months of follow-up. Results : Following six to 12 months of inhaled corticosteroids or leukotriene modifiers treatment, the geometric mean (range of 1 SD) of methacholine PC20 was significantly changed in the atopic asthma group [2.20 mg/mL (0.41-11.82) vs. 6.69 mg/mL (1.25-35.87), P=0.000] but not in non-atopic asthma group [2.41 mg/mL (0.90-6.42) vs. 2.46 mg/mL (0.62-9.78), P=0.065]. Blood total eosinophil counts and serum ECP levels decreased significantly over one year in atopic asthma, while these changes were not observed in non-atopic asthma. Significantly higher FEV1 %predicted values (98.3±6.6%) were noted at 12 month follow-up compareed to the initial values (92.9±11.4%, P=0.023) in the non-atopic asthma group. Conclusion : Inhaled corticosteroids or leukotriene modifiers treatment resulted in a significantly decreased bronchial hyperresponsiveness in children with atopic asthma. This effect was reflected primarily by reduced blood eosinophilic inflammation. The persistence of bronchial hyperresponsiveness in children with non-atopic asthma might be related with genetic factors or airway remodeling other than eosinophilic inflammation. 목 적 : 아토피성 천식 환아와 비아토피성 천식 환아에서 천식 치료 후 기관지 과민성을 측정하고, 기관지 과민성의 변화와 관계된 요소에 관하여 알아보고자 본 연구를 시행하였다. 방 법 : 2005년 3월부터 2006년 2월까지 고려대학교 안암병원 소아 알레르기 크리닉과 서울대학교병원 소아 알레르기 크리닉을 방문하여 혈액검사, 피부단자시험, 메타콜린 유발시험을 시행 후 기관지 천식으로 진단받은 7세 이상 소아 중에서 진단 이후 6개월에서 1년 동안 크리닉을 정기적으로 방문하여 흡입용 스테로이드와 류코트리엔 길항제 등으로 치료 받은 후 1년 후에 폐기능 검사, 메타콜린 기관지 유발시험, 피부단자시험 및 알레르기 염증 지표들에 대한 혈액 검사를 반복 시행하였다. 결 과 : 대상 환아는 총 45명으로 나이(중간값, 범위)는 아토피성 천식(37명)이 10.1년(6.6-15.2), 비아토피성 천식(8명)이 9.7년(6.9-14.7)이었으며, 규칙적으로 흡입용 스테로이드를 사용한 환아는 아토피성 천식군 86.5% (32/37), 비아토피성 천식군75.0% (6/8)으로 두 군간에 유의한 차이는 없었다. 아토피성 천식군에서 진단 시와 추적 검사 시 메타콜린 PC20의 기하평균(1 SD의 범위)은 각각 2.20 mg/mL (0.41-11.82)와 6.69 mg/mL (1.25- 35.87)로 유의한 차이가 있었고, 혈청 IgE치는 약간 감소하였으나 유의하지 않았고[459.6 IU/mL (79.1-778.5) vs. 332.1 IU/mL (61.2-599.8)], 말초혈액 총 호산구수[324.8/µL (136.1-550.9) vs. 256.0/µL (101.8-442.8)]와 혈청 ECP값[47.8 µg/ L (11.4-57.2) vs. 18.9 µg/L (5.7-39.5)]은 유의한 감소를 보였다. 비아토피성 천식군에서는 FEV1의 정상 예측치에 대한 비율(92.9±11.4% vs. 98.3±6.6%)은 진단 시에 비해 추적 검사 시에 유의한 호전을 보였으나, 메타콜린 기관지 과민성과 혈중 호산구성 염증지표의 유의한 변화는 관찰되지 않았다. 아토피성 천식군의 메타콜린 기관지 과민성의 변화는 평균 1.533 배가선량(DD)으로 비아토피성 천식군의 0.056 DD 보다 크게 나타났다. 결 론 : 아토피성 천식 환아들에서 스테로이드 및 류코트리엔 길항제 등으로 천식 치료 1년 후에 측정한 기관지 과민성은 유의한 감소를 보였으며 이는 기도 염증의 감소에 기인하는 것으로 해석할 수 있다. 그러나 비아토피성 천식 환아들은 치료 후 폐기능의 호전은 있었으나 기관지 과민성과 호산구성 염증 지표들은 감소하지 않았고 따라서 비아토피성 천식 환아의 기관지 과민성은 기도 염증 이외에 다른 유전적 요소나 기도 개형과도 같은 요인과 관련이 있는 것으로 생각할 수 있다.

좌측 방사관 경색에 의해 발생한 자동-수의적 조절 해리를 보이는 하부 뇌신경마비와 조음불능증: Foix-Chavany-Marie증후군

김건하,윤영신,김용재,김정은,박기덕,최경규,정지향 대한신경과학회 2008 대한신경과학회지 Vol.26 No.4

Foix-Chavany-Marie Syndrome (FCMS) is characterized by anarthria and bilateral facio-pharyngo-glosso-masticatory paralysis with an automatic-voluntary dissociation, which usually develops in bilateral opercular lesions. We present a case of FCMS caused by unilateral subcortical lesion. A 54-year-old man was admitted due to acute right hemiparesis with anarthria. He had voluntary facial paresis but automatic-involuntary facial movements were preserved. MRI showed an acute left corona radiata infarction and PET revealed decreased glucose metabolism in left basal ganglia and fronto-parietal lobe.

Sustainability of the In Situ Bio-barriers for Contaminant Containment in Residual Soils

김건하,Jong Heun Kim 대한토목학회 2004 KSCE JOURNAL OF CIVIL ENGINEERING Vol.8 No.2

An iterative dynamic condensation method for the model reduction is presented in this paper. Dynamic condensation method has been widely applied to large finite element models for faster computation of the natural frequencies and mode shapes. It has also been used in correlation of test-analysis models, vibration control, and structural dynamic optimization. Based on the subspace iteration method, an iterative dynamic condensation technique is employed. The proposed method has three advantages compared with other iterative schemes proposed in the past: (1) The convergence is much faster than all these methods, especially when the eigenpairs of the reduced model are close to those of the full model. (2) Since the dynamic condensation matrix is independent of the eigenpairs of the reduced model, it is unnecessary to calculate the stiffness and mass matrices in every iteration. (3) The convergence of the iterative scheme can be proved simply. Two iteration schemes, which are based on the convergence of the eigenvalues of the reduced model, are introduced. Numerical examples are presented to verify the effectiveness of this technique.

오염퇴적물 관리방향 및 처리공법

김건하,정우혁,Kim, Geon-Ha,Jeong, Woo-Hyeok 한국지하수토양환경학회 2007 지하수토양환경 Vol.12 No.3

수질오염 총량제가 시행됨에 따라 깨끗한 수자원을 확보하기 위한 오염퇴적물의 관리 및 처리 필요성이 더욱 높아지고 있다. 본 논문에서는 오염퇴적물의 발생원과 오염퇴적물이 수질에 미치는 영향을 살펴보고, 오염퇴적물의 관리방향을 제시하였다. 오염퇴적물을 처리하기 위한 공법으로 준설공법과 자연정화법, 현장고정화/안정화, 생물학적 현장처리, 화학적 현장처리 공법에 대하여 요약 제시하였다. 또한 새롭게 대두되고 있는 캡핑공법을 소개하고, 오염퇴적물 처리를 위한 복합공법의 적용에 대한 개념을 제시하였다. As Total Maximum Daily Load program is being implemented, needs for the management and treatment of contaminated sediment are rising to attain cleaner water resources. In this paper, impacts and management methods of contaminated sediment were reviewed. Remediation technologies for contaminated sediment including dredging, natural attenuation, in situ solidification/stabilization, in situ biological remediation, in situ chemical remediation and capping were reviewed. Integrated remediation scheme was presented as well.

Clopidogrel 투여 후 발생한 급성 혈소판 감소증

김건하,권주영,박기덕,주은연 대한신경과학회 2007 대한신경과학회지 Vol.25 No.4