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만성 골수성 백혈병에서 인터페론 및 화학요법의 병용과 화학요법 단독에 의한 치료효과
김동집(Dong Jip Kim),유진홍(Jin Hong Yoo),권혁호(Hyuk Ho Kwan),이일중(Ill Jung Lee),한치화(Chi Hwa Han),박종원(Chong Won Park),김춘추(Choon Choo Kim),김학기(Hak Gi Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.4
N/A Interferon`s ability to reduce the self-renewal capacity of leukemic Stem cells as well as the exgression of oncogens and to increase natural kilier cell cytotoxicity promptoly made ue study it`s synergistic therapeutic efficacy with chemotherapy on patients with chronic myelocytic leukemia, 29 patients with philadephia ehromos6me positivity had begun the study with protocol consisted with subcutaneous daily dose of 1 or 2 mega unit of interferon alpha and chemotherapy. Among them, 21 were on chronic phase, 8 on ndvaneed disease. 12 patients of chronic phase have had hematological complete response (57.1% ) and 4 of advanced diseases returned to chronic phase again. Also we had selected another 25 patients who have had chemotherapy only as a controls far comparison. Among 25 of them, 22 were on chronic phase, only 3 could enjoy hematological complete response (13,6%). 3 on advanced disease had no response with chemotherapy alone. There has been a significant slowing of the leukocyte doubling time and reduction of the hydroxyurea requirement in interferon responded patients A few (25 %) of them had psrtia1 cytogenetic remission in their bone marrow and peripheral blood. Even if our date is still in immature because of the short period of observation, it give us a speculation that our protocal of combi0ed modality might be another new thereapeutic option for patients with chronic myelocytic leukemia.
강성구,이광우,손호영,차봉연,홍관수,권혁호,홍현상 대한내분비학회 1988 Endocrinology and metabolism Vol.3 No.1
An unusual multisystemic syndrome of polyneuropathy, organomegaly, endocrinopathy, dysgammaglobulinemia and skin changes has been recorded in the literature since 1968. In 1980, this syndrome was designated as POEMS syndrome by Bardwick corresponding to the cardinal features. Only very little has been learned about the nature of this disorder. Recently we have had the opportunity to attend one patient with clinical features similar to this syndrome. She was a 49-years-old woman who had a progressive polyneuropathy, hepatosplenomegaly, diabetes mellitus, amenorrhea and anasarca. Hyperpigmentation and thickening of the skin, pailledema, hypothyroidism, hypoparathyroidism have also been noted. The findings of bone marrow aspiration showed that the plasma cells were increased in number. Thus, we report a case with a review of the literature.