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권태은,정윤선,하위호,진영우 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.8
Administration of stable iodine has been considered a best measure to protect the thyroid from internal irradiation by radioiodine intake, and its efficacy on thyroid protection has been quantitatively evaluated in several simulation studies on the basis of simple iodine biokinetic models (i.e., three-compartment model). However, the new iodine biokinetic model adopted by the International Commission on Radiological Protection interprets and expresses the thyroid blocking phenomenon differently. Therefore, in this study, the new model was analyzed in terms of thyroid blocking and implemented to reassess the protective effects and to produce dosimetric data. The biokinetic model calculation was performed using computation modules developed by authors, and the results were compared with those of experimental data and prior simulation studies. The new model predicted protective effects that were generally consistent with those of experimental data, except for those in the range of stable iodine administration 72 h before radioiodine exposure. Additionally, the dosimetric data calculated in this study demonstrates a critical limitation of the three-compartment model in predicting bioassay functions, and indicated that dose assessment 1 d after exposure would result in a similar dose estimate irrespective of the administration time of stable iodine
권태은,권오상,정진호,조광현,윤재일 대한피부과학회 1999 대한피부과학회지 Vol.37 No.4
Background: Chronic cutaneous lupus erythematosus(CCLE) is a well-known disease entity. But there has been no data about its clinical behavior and histopathologic features in Korea. Objectives: This study was conducted to elucidate the clinical, laboratory, and histopathologic features of CCLE, and the relationship between CCLE and SLE. Materials and Methods: We investigated 48 cases of CCLE that visited the department of dermatology at the Seoul National University Hospital from January 1990 to June 1997. Medical records and biopsy slides were reviewed. Results : The results were as follows: 1. Clinical manifestations and laboratory findigns: DLE lesions were well defined erythematous scaly patches and plaques. LE profundus lesions were presented as atrophic patches, indurations, and subcutaneous nodules. Photosensitivity was the most common associated clinical finding. ANA and leukopenia showed high positive rates. 2. Histopathologic findings of DLE: Epidermal abnormalities such as epidermal atrophy, epidermal colloid bodies were found in rather a few cases. Dermal mucin deposition was found in 53.8% of cases and can be an important patholohgic finding. 3. Histopathologic findings of LE profundus: Epidermal changes (liquefation degeneration of the basal layer) were found in 44.4% of cases. There were no consistent findings except lymphocyticlpanniculitis and hyaline fat necrosis. 4. Twenty one percent of patients who were presented with DLE were diagnosed as SLE. There was no difference between DLE and LE profundus. Widespread DLE patients fulfilled the SLE criteria in twice as many cases as that of localized DLE. 5. Seventy four percent of CCLE patients were treated with hydroxychloroquine alone or in combination with other agents. Seventy nine percent of them showed clinical improvements. Conclusion: Photosensitivity, oral ulcer, arthralgia were associated with CCLE. ANA and leukopenia were the most common laboratory abnormalities. CCLE patients fultilled the diagnostic creiteria of SLE in 21.4% of cases. Pathological findings were similar to those of previous resports, but DLE showed less epidermal changes and more mucin deposition.