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권용대,이홍식,박철희,진윤태,전훈재,이상우,최재현,김창덕,류호상,현진해 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.1
Auto-immune hepatitis is a chronic necroinflammatory liver disorder that is characterized by hypergamma-globulinemia, auto-antibodies in serum, and, on histological examination, the presence of periportal hepatitis. Although it can be associated with a number of other auto-immune diseases, Sjo¨gren’s syndrome is rarely associated with auto-immune hepatitis. We herein report an unusual case of auto-immune hepatitis associated with primary Sjo¨gren’s syndrome. A 39-year-old woman was admitted to our hospital due to jaundice. Laboratory data showed negative viral hepatitis marker, increased serum IgG level, positive anti-nuclear antibody, and an increased rheumatoid factor titer. The patient had no history of taking medications and alcohol. Based on characteristic clinical features, live biopsy findings, positive Schirmer’s test, and salivary scintigraph, she was diagnosed as having auto-immune hepatitis and Sjo¨gren’s syndrome. The patient achieved complete remission with steroid monotherapy.