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권민수 대한이비인후과학회 2022 대한이비인후과학회지 두경부외과학 Vol.65 No.3
The locoregional recurrence rate after treatment of head and neck cancer (HNC) is known tobe about 40%, and recurrence of cancer is the major factor directly related to the survival ofpatients. Recurrent HNC has different biological characteristics and tumor microenvironmentfrom those of index cancer. And it subsequently exhibits pro-tumoral and treatment-resistanttraits, which leads to difficulties in selecting salvage treatments and followed by dismal prognosis. Furthermore, since which salvage treatment can be selected and what the result of itwill be determined by the prior treatment, there should be careful consideration in the initialtherapeutic strategy. In this review, currently used treatment methods and results for locoregionallyrecurrent HNC are summarized, and considerations for each treatment based on theclinical and biomolecular characteristics of recurrent HNC are discussed. In addition, this reviewcontains introductions of new therapeutic strategies including recent clinical trials and aperspective on the future direction for treatment of locoregionally recurrent HNC.
권민수,장용주,이봉재,정유삼 대한이비인후과학회 2010 Clinical and Experimental Otorhinolaryngology Vol.3 No.3
Objectives. This study investigated the outcomes of uvula-preserving palatopharyngoplasty (UPPPP) in patients with obstructive sleep apnea syndrome (OSAS). Methods. Twenty men with obstructive sleep apnea syndrome received the UPPPP operation at our institution. We measured symptom changes after UPPPP using a visual analog scale (VAS), and all patients were examined with polysomnography pre- and post-operatively. ‘Surgical success’ was defined as reduction in apnea-hypopnea index (AHI) to below 20 events per hour and more than 50% post-operative reduction. Results. Snoring decreased significantly (6.7±2.3 to 3.7±2.9 on VAS, P=0.002) but the postoperative globus sense did not differ from that preoperatively (2.0±2.4 to 2.1±2.7 on VAS, P=0.79). Apnea and apnea-hypopnea indices were significantly reduced after UPPPP (34.7±20 to 24.2±17.2 events/hour, P=0.029). The surgical success rate was 40% regardless of Friedman stage. There was significant reduction in the AHI on supine sleep in both surgically successful and unsuccessful patient groups. Conclusion. UPPPP may minimize postoperative globus sense and other complications, with a success rate comparable to that of previously reported surgical methods in OSAS patients. In addition, it may reduce the apnea-hypopnea index in the supine sleep position.
고실 내 저농도 젠타마이신 주입술을 통한 메니에르병의 치료
권민수,이성부,안중호,윤태현,정종우 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.4
Background and Objectives:Intratympanic gentamicin injection is used as one of the treatment modalities for medically intractable Meniere’s disease. But the ideal dosage and concentration of gentamicin were not established in consideration of therapeutic efficacy and the risk of postoperative hearing loss. We analyzed the clinical outcome of low-concentration intratympanic gentamicin injection in patients with Meniere’s disease. And we also tried to find factors anticipating for the response to treatment. Subjects and Method:A retrospective review was conducted on 45 subjects who had been diagnosed as ‘definite’ Meniere’s disease (AAO-HNS, 1995) and had no response to medical treatment over 3 months in our clinic. The concentration of gentamicin was 7 mg/cc, which was very low compared with previous studies. We reviewed postoperative changes on vertigo, tinnitus and hearing by questionnaire and pure tone audiometry. We also analyzed preoperative patients’ characteristics for acquisition of predictive factors of treatment response. Results:Vertigo was completely disappeared in 37 (82%) patients and there was no vertigo improvement in 8 (18%) patients despite multiple injections. Tinnitus was controlled in 11 (24%) patients, and aggravated in 4 (8%) patients. A significant postoperative hearing loss over 10 dB occurred in only 6 (13%) patients. Preoperative patients’ hearing threshold, frequency of vertigo, functional level and finding in electrical test, such as electrocochleogram, were not different regarding treatment response. Conclusion:Low-concentration gentamicin was enough to control vertigo and could reduce the risk of postoperative hearing loss in patients with Meniere’s disease.
권민수,Eon-Jeong Shim,서영준,Seong-Soo Choi,Jin-Young Lee,Han-Kyu Lee,서홍원 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.5
The present study was designed to characterize the possible roles of spinally located cholera toxin (CTX)- and pertussis toxin (PTX)-sensitive G-proteins in pro-inflammatory cytokine induced pain behaviors. Intrathecal injection of tumor necrosis factor-a (TNF-α; 100 pg), interleukin- 1β (IL-1β; 100 pg) and interferon-γ (INF-γ; 100 pg) showed pain behavior. Intrathecal pretreatment with CTX (0.05, 0.1 and 0.5 mg) attenuated pain behavior induced by TNF-α and INF-γ administered intrathecally. But intrathecal pretreatment with CTX (0.05, 0.1 and 0.5 µg) did not attenuate pain behavior induced by IL-1β. On the other hand, intrathecal pretreatment with PTX further increased the pain behavior induced by TNF-α and IL-1β administered intrathecally, especially at the dose of 0.5 µg. But intrathecal pretreatment with PTX did not affect pain behavior induced by INF-γ.Our results suggest that, at the spinal cord level, CTX- and PTX-sensitive G-proteins appear to play important roles in modulating pain behavior induced by pro-inflammatory cytokines administered spinally. Furthermore, TNF-α, IL-1β and INF-γ administered spinally appear to produce pain behavior by different mechanisms.
소목 천연 염색에 관한 연구 I-정제 알루미늄 화합물들의 매염효과에 대하여-
권민수,전동원,최인려,김종준 복식문화학회 2004 服飾文化硏究 Vol.12 No.5
Currently, as mordants, heavy metals are being used in dyeing process in order to improve dye uptake and dye fastness. These chemicals, however, are mostly harmful to human body and the environment along with the pollution by effluent. Traditionally, rice straw ash solution, lime, etc. have been used as mordants in order to improve the effects on dye uptake and color fastness of dyestuffs. The study of natural mordants would, therefore, be vital to the development and succession of our traditional dyeing methods. In this study, as a preliminary step toward the use of rice straw ash solution for the nautral dyeing using Caesalpinia sappan, several aluminum compounds were employed as mordants. When the purified aluminum compounds were used, on the basis of unmordanted cotton fabric, the K/S values of the pre-mordanted and simultaneously mordanted fabrics increased by 2 or 3 times, while those of the post-mordanted fabrics decreased.
CFRP 철근으로 보강된 콘크리트 부재의 비선형 유한요소해석
권민수,모르타자비 세예드 자바드,허종완 한국콘크리트학회 2023 콘크리트학회논문집 Vol.35 No.2
철근콘크리트 구조물의 철근부식은 구조물의 유지관리 및 보수비용의 증가, 구조물의 수명 단축, 나아가 구조물의 파괴까지 초래한다. 강철 철근의 부식을 방지하는 가장 적합한 방법 중 하나는 강철 철근을 탄소섬유강화폴리머(CFRP) 철근으로 교체하는 것입니다. CFRP 철근은 강철보다 저항이 높지만 강철과 달리 부서지기 쉬우며 콘크리트 구조에서 그 효과를 조사해야 한다. 본 연구에서는 CFRP bar를 적용한 철근콘크리트 기둥의 보, 기둥, 전단벽 이원슬래브 및 보-기둥 접합부의 거동을 조사하기 위하여 각각 1개의 모형을 적용하중하에서 유한요소법을 이용하여 분석하였으며, 그 결과를 제시하였다.
권민수,안중호 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.3
Skull base osteomyelitis is originated from inappropriately treated chronic infections near the skull base. If diagnosis and treatment are delayed, it occasionally causes multiple cranial nerve palsy, with the mortality rate being as high as 60%. Skull base osteomyelitis typically evolves as a complication of external otitis in diabetic patients, so it has been thought as a synonym for malignant external otitis. However, the routes of infection are diverse. We experienced two patients of atypical skull base osteomyelitis after mastoidectomy. It is an unusual complication of mastoidectomy, so we report about these cases.
권민수,이진구,박수현,심윤범,정준섭,서홍원,원무호,김선미 대한약리학회 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.5
Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition of calcium influx into blood cells. However, the neuroprotective effect of visnagin was not clearly known until now. Thus, we investigated whether visnagin has a neuroprotective effect against kainic acid (KA)-induced neuronal cell death. In the cresyl violet staining, pre-treatment or post-treatment visnagin (100 mg/kg, p.o. or i.p.) showed a neuroprotective effect on KA (0.1 μg) toxicity. KA-induced gliosis and proinflammatory marker (IL-1β, TNF-α, IL-6, and COX-2) inductions were also suppressed by visnagin administration. These results suggest that visnagin has a neuroprotective effect in terms of suppressing KA-induced pathogenesis in the brain, and that these neuroprotective effects are associated with its anti-inflammatory effects.