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권기한,민양기 대한근전도전기진단의학회 2016 대한근전도 전기진단의학회지 Vol.18 No.1
Primary cancers evolving from neuromuscular system are rare. However, neuromuscular system involvement is common in cancer patients. All part of neuromuscular system including motor neurons in the spinal cord, sensory dorsal root ganglia, nerve roots, plexuses, cranial nerve, peripheral nerves and neuromuscular junctions. These include metastasis, paraneoplastic syndrome, toxicity of cancer treatment, infection due to immune suppression and metabolic/nutritional issue. . In this review we discuss the different causes and mechanisms of disorders of the neuromuscular system in patients with cancer.
권기한,민양기 대한근전도전기진단의학회 2013 대한근전도 전기진단의학회지 Vol.15 No.2
Intensive care unit-acquired weakness (ICUAW) is common in patients with critical illness. Critical illness neuropathy (CIN), critical illness myopathy (CIM), and critical illness neuromyopathy (CINM) are the main parts of ICUAW. It is associated with delayed weaning from ventilation, delayed discharge from intensive care unit (ICU) and hospital, and increased in-hospital mortality. It also causes chronic disabilities in survivors. But it is hard to diagnose because of various patients' conditions. Endotracheal intubation, sedation or coexistent encephalopathy, neuromuscular blockade, and electrical equipments in ICU prevent careful examination. And other neuromuscular diseases can also mimic ICUAW. Muscle excitability loss, muscle atrophy, loss of myosin and neuropathy are mainly involved in its pathogenesis. Main risk factors which are related with ICUAW are sepsis, multiorgan failure, hyperglycemia. Steroids, neuromuscular blocking agents, and immobility, which are controversial are also thought as risk factors. I would like to review the pathogenesis, clinical features, and diagnostic criteria of each of ICUAW.
권기한 대한근전도전기진단의학회 2012 대한근전도 전기진단의학회지 Vol.14 No.1
Since Hoch et al reported the presence of antibodies to muscle specific receptor tyrosine kinase (MuSK) in seronegative myasthenia gravis (MG), MG with MuSK antibodies (MuSK-MG) has been reported to have unique clinical features, diagnostic problems and response to treatment. Patients with MuSK-MG have a tendency of early and frequent involvement of bulbar muscles, often associated with prominent facial or tongue atrophy. Diagnostic yields of edrophonium test, and electrophysiologic tests, such as repetitive nerve stimulation test (RNS) and single fiber electromyography (SFEMG) are lower than in patients with acetylcholine receptor antibodies (AChR-MG). When doing edrophonium test or treating with acetylchoinesterase inhibitors, they often show intolerance (muscarinic and nicotinic side effects) and even show worsening of muscle weakness (hypersensitivity). However, because most of studies included small numbers of MuSK-MG patients, there have been some discrepancies among reports. And there have been questions about pathogenesis of MuSK antibodies to induce muscle weakness.I would like review the pathogenesis, clinical features, diagnosis, and treatment of MuSK-MG
권기한,서민식,민승재 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.6
An electric vehicle (EV) powertrain is comprised of a motor and reduction gear. Thus, it must be designed by considering both components to improve its dynamic and economic performances. To obtain the optimal design of powertrain components for an EV, this study employs a two-stage analysis model focusing on the motor and vehicle at each stage for accuracy and efficiency. In the first stage, a motor system model analyzes the motor characteristics, such as the maximum and minimum torque and motor losses. Using the motor design parameters, these characteristics are converted to torque curves and an efficiency map. In the second stage, a vehicle system model analyzes the target performance using converted motor data for efficient analysis of the performance. An optimization problem is formulated to minimize the maximum motor power, acceleration time, and energy consumption with dynamic constraints, including the maximum vehicle speed and ascendable gradient. To reduce the excessive computational effort when conducting the multi-objective optimization, surrogate models with respect to performance are effectively constructed by using the adaptive sampling method. From the optimization results, a Pareto front having various solutions among the objective functions is obtained.