http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
백서 재생간의 DNA topoisomerase Ⅰ 에 관한 연구
권기량,임규,황병두 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1
The study was performed to evaluate changes of activity of DNA topoisomerase I that controls and modifies the topological state of DNA according to postoperative days after partial hepatectomy. The results of this experimental study were summarized as follows : 1. The liver mass doubles during the first 48 hours, and the rate of regeneration is greatest between first and second days after partial hepatectomy. 2. 25% of enzyme activity was increased in the first 12 hours in comparison with that of control after partial hepatectomy. The second days showed maximal increment. 200% in comparison with that of control. Later, enzyme activity was decreased till the seventh days after partial hepatectomy. 3. DNA Topo I was inhibited very slightly be camptothecin but 50% of enzyme activity was inhibited at 50μM of 10-hydroxycamptothecin. 4. In the case of spermine. 0.1mM. Complex formation was highest as 0.1mM spermine. 5. The enzyme shows a pH optimum around 6.4, but enzyme activity is seen within a broad range between pH 5.8 and 9.0. 6. The enzyme is completely inactivated by heat treatment for 5 minutes at 50℃. 7. 2mM Mg^2+ activates the enzyme activity over 3-folds. Cu^2+, Zn^2+ completely inhibit it and Mn^2+, Co^2+, and Se^2+ inhibit upto 40%, 40% and 60% at 2mM respectively. 8. There was no sighificant difference between resection and regeneration liver. These results suggested that the role of DNA topoisomerase I is related to 2nd peak of DNA synthesis in regeneration of liver after partial hepatectomy.
권기량(Kwon Kiryang),변융태(Byeon Yoong-Tae),김진오(Kim JinO) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
The railway is required to be highly reliable, which carries a lot of passenger and baggage. Presently, the reliability prediction method is based on independent failure. If the common cause failure affecting many components simultaneously in a system occurs, the system has seriously an aptitude to be broken out. Therefore, for raising the reliability of the railway power system, it is introduced that the analysis is conducted to use the common cause failure. The common cause failure is modeled and is combined with independent failure. Furthermore in order to examine the method, it is applied to the railway power substation. If this method is used to the power system, the reliability of the railway power system will be highly improved.
Free-rider and Independent Feature Checking
Kwon, Ki Yang 신한영미어문학회 1998 새한영어영문학 Vol.39 No.-
본 소고에서는 Chomsky (1995)의 Minimalist Program (최소이론)에서 가정되어지고 있는 자질의 무임승차이론(free-rider strategy)이 영어의 there-구문과 일본어의 비양도 소유구문 (inalienable possession construction)에서 문제점을 야기시킬 수 있다는 것을 보이고, 이에 대한 해결방안으로 개별자질 점검이론(Independent Feature Checking)을 제안한다. Chomsky (1995)는 하나의 어휘항목에서 한 형식자질(formal feature)이 유인(attract)될 때 그 어휘 항목의 다른 모든 형식자질이 무조건 무임승차되어 따라 간다고 주장한다. 그러나 본 고에서는 이러한 가정은 wh-이동과 conjuct associate를 포함한 there-구문에서 문제점을 야기시킨다고 제안한다. 즉 C의 강한 wh-자질이 관련 명사구(associate)의 wh-자질을 유인할 때, 관련 명사구의 나머지 형식 자질들이 무임승차되어 유인된다고 가정하면, there의 [D]-자질이 visible하게 되어 그 구문은 crash를 일으키게 된다. 그러나, 이러한 구문은 실제로 정문으로 나타난다. 이러한 문제점을 해결하기 위하여, 본 고에서는 "자질의 유인 과정에서는 도출 과정의 각 단계의 convergence에 꼭 필요한 최소한의 형식 자질들만 이동하며, 자질 점검은 각각의 개별적인 형식 자질로 이루어질 수 있다"는 제안을 한다. 개별자질점검이론의 또다른 증거로서 본 고에서 일본어의 비양도 소유구문을 제안하고 있다. 일본어의 비양도 소유구문는 T의 outer Spec으로 이동한 possessor DP가 subject-oriented anaphor인 'zibun'을 bind 해주지 못한다. 무임승차 이론에 따르면 일본어의 비양도 소유구문에서는 T의 case-자질이 multiple feature checking에 의해 possessor DP의 case-자질을 유인할 때 possessor DP의 다른 형식 자질이 무임승차되어 따라간다면 T의 outer Spec으로 이동한 possessor DP는 'zibun'을 꼭 bind해주어야 한다. 이것은 subject-oriented anaphor는 T의 EPP-자질과 점검을 이룬 DP에 의해 license 받을 수 있다는 주장에 근거한다. 그러므로 일본어의 비양도 소유구문애서 자질의 무임승차이론은 어떤 문제점을 가진다고 할 수 있겠다. In this paper, we will suggest that it is not required that when the operation move-F affects a FF, all FFs associated with F move to the target as free riders. Rather, we will assume that only the necessary formal feature of the moved element individually enters into a checking relation with the target that has matching features for a convergence at the relevant stage of derivation, and that the feature checking may hold between individual formal features that have matching features that can enter into checking relations. This suggestion is based on the there-constructions involving wh-movement and the conjunct associate, and the subject properties of the raised possessor DP in inalienable possession constructions of Japanese
사람 태반조직 DNA Topoisomerase Ⅰ에 관한 연구
이정복,권기량,임규,황병두 ( Jeong Bok Lee,Gi Ryang Kweon,Kyu Lim,Byung Doo Hwang ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.4
DNA topoisomerase I has been purified from human term placenta approximately 520-folds with a 10% yield. The enzyme shows a broad pH optimum from pH 6 to 9 and is heatlabile, being completely inactivated by heat treatment at 50℃ for 5 min. The enzyme is activated by K^+ and Na^+ approximately 20 and 8-folds respectively. Magnesium ion (Mg^(2+)) is the most potent activator, the activity being 20 and 40-folds activated at 2 mM and 10 mM respectively. But copper ion (Cu^(2+)) is a potent inhibitor. In the presence of Mg^(2+) and K^+, the enzyme is inhibited by physiologic concentration of ATP and GTP. Inhibitory mechanism of ATP is considered to be a inhibition of readoptation of active enzyme conformation and that of GTP is to be a inhibition of the prior step of DNA rejoining. The molecular weight is around 68,000. Camptothecin and 10-hydroxycamptothecin inhibit this enzyme, and the inhibitory action of 10-hydroxycamptothecin is potentiated by Mg^(2+) and K^+. DNA fragmentation by 10-hydroxycamptothecin is more potent than that by camptothecin in the DNA cleavage assay. Heparin and Cu^(2+) inhibit the prior step of DNA rejoining by this enzyme. From the above results, the inhibitory action mechanism of ATP, GTP, heparin, Cu^(2+) and the possible role of Mg^(2+) and K^+ for potentiating the inhibitory action of 10-hydroxycamptothecin, and the development the anticancer drug against DNA topoisomerase I as a target enzyme are discussed.