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누드마우스에 이식된 인체 대장암 모델에서 주입된 항 CEA 단세포군 항체의 종양내 집적에 관련하는 인자
궁성수(Sung Soo Koong),김승택(Seoung Taik Kim),이복희(Bok Hi Lee),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh),정홍근(Hong Keun Chung) 대한내과학회 1992 대한내과학회지 Vol.43 No.5
It has been supposed that several factors are related to the localization of antibody against tumor-associated antigen in tumors. However, the significance of these factors has not been evaluated in detail. The purpose of the present study was to analyze the effect of these factors on the localization of infused monoclonal anti-CEA (CEA 79), expressed in percent injected dose per gram (%ID/G), in human colon carcinoma grafted to nude mice. The evaluated factors in tumor were tissue weight, blood weight, vascular permeability to antibody, relative blood flow and CEA concentration (Bmax). The percent injected dose per gram of CEA 79 in tumor correlated significantly with vascular permeability (r= 0.61, p<0,001) and CEA concentration in tumor (r= 0.49, p<0.001), while tissue weight, blood weight and relative blood flow did not show a significant correlation (p>0.05) in linear regression analysis. Stepwised multiple regression analysis in tumor indicated that vascular permeability was a significant predictor of the percent injected dose per gram (multiple R=0,59, p<0,001). Inclusion of CEA concentration in tumor increased the correlation coefficient from 0.59 to 0.67 (p<0.001). Adding all the other variables was not significant (p>0.05). In conclusion, vascular permeability to antibody and CEA concentration in tumor were important factors determining the localization of CEA 79 in human colon carcinoma grafted to nude mice.
미니돼지에서 <sup>99m</sup>Tc-Tin colloid와 <sup>99m</sup>Tc-DISIDA를 사용한 간신티그라피의 비교 연구
심경미,김세은,이원국,궁성수,배춘식,이재영,최석화,한호재,강성수,박수현,Shim, Kyung-Mi,Kim, Se-Eun,Lee, Won-Guk,Koong, Sung-Soo,Bae, Chun-Sik,Lee, Jae-Yeong,Choi, Seok-Hwa,Han, Ho-Jae,Kang, Seong-Soo,Park, Soo-Hyun 한국생명과학회 2006 생명과학회지 Vol.16 No.6
동물 모델에서의 간기능의 비침습적 평가는 하나의 과제로 남아있다. 간신티그라피는 간의 크기 및 모양의 변화에 대한 정보를 제공할 뿐 아니라 간의 전체적인 기능을 파악할 수 있게 해 주며 간이식의 주요 합병증인 간염, 거부반응 및 담도계 합병증의 진단에도 편리하게 사용될 수 있다. 이에 본 연구에서는 미니돼지의 간 기능을 평가하기 위해 사람에서 주로 사용되는 방사성의약품인 $^{99m}Tc-Tin$ colloid와 $^{99m}Tc-DISIDA$를 이용하여 간 및 간담도 신티그라피를 시행하였다. 그 결과, 사람의 간신티그라피와 달리 미니돼지에서는 $^{99m}Tc-Tin$ colloid가 폐, 간, 위벽 및 신장에 섭취되고 폐와 간의 영상이 겹쳐져 간의 관심영역을 설정할 수 없었다. 그러나 $^{99m}Tc-DISIDA$를 사용한 간담도 신티그라피에서는 심장, 폐, 간, 담낭 및 십이지장으로의 연속적 방사능섭취를 관찰할 수 있었다. 따라서 미니돼지에서의 $^{99m}Tc-Tin$ colloid의 사용은 비특이적 결합력으로 인해 간 기능 평가를 위한 영상에는 적합하지 않으나 $^{99m}Tc-DISIDA$는 간담도 기능을 파악하는데 있어 좋은 수단이 될 수 있을 것으로 생각된다. Non-invasive evaluation of liver function in animal models remains a challenge. Hepatoscintigraphy provides information about changes in liver size and shape, and enables to understand general liver function. Futhermore it is readily used to diagnosis complications of liver transplantation like hepatitis, rejections and biliary complications. In this study, we investigated the usefulness of evaluating the liver function in miniature pigs with $^{99m}Tc-Tin$ colloid and $^{99m}Tc-DISIDA$ which are the most commonly used radiopharmaceuticals in human medicine. In result, $^{99m}Tc-Tin$ colloid was uptaked in lung, liver, gastric wall and kidney in miniature pigs. And $^{99m}Tc-DISIDA$ showed continuous uptake images of heart, lung, liver, gallbladder and duodenum, and it was similar to human's. Therefore we could conclude $^{99m}Tc-Tin$ colloid would not be suitable for evaluating hepatic function because of it's nonspecific affinity, however $^{99m}Tc-DISIDA$ scintigraphy would be an effective method for detecting hepatobiliary function in miniature pigs.
관상동맥질환에서 심장풀 스캔의 육안적 평가에 대한 ROC 분석
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),문대혁(Dae Hyuk Moon),궁성수(Sung Soo Koong),이범우(Bum Woo Lee),최윤호(Yoon Ho Choi),이경한(Kyun Han Lee) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.2
N/A Visual assessment of regional wall motion abnormality (RWMA) by gated blood pol scan (GBPS) serves as an useful parameter in thc diagnosis, functional evaluation, and follow up in various clinir.al settings, but are still subject to some inherent limitations. On important problem may be the interobserver as well as intraobsever variation that may well be present due to the subjective nature of the interpretations. This study was carried out to determine the reliability and reproducibility of visual assessments made in GBPSs, and to observe the degree to vihich the results would be influenced by observer variation. Fifty two patients with coronary heart disease had resting GBPS and contrast ventriculography v;ithin 4 days appart. Contrast ventriculography showed normal wall motion in 6 patients and the remaining 46 had RWMA in one or more segments. The anterior and left anterolateral views of all 52 GBPSs were analyzed by three independent observers, who selected from 5 scales, their 1nel of confidence that there was RWMA in that segment. Reciever operating characteristic (ROC) curves for each analysis was plotted and the area under the curue (B) was used as a parameter representing each observers perf<nrnance in his interpretations. The findings of contrast ventriculographies were used as the standard for RWMA. The apical and inferoapical segments showed the best Visual assessment of regional wall motion abnormality (RWMA) by gated blood pol scan (GBPS) serves as an useful parameter in thc diagnosis, functional evaluation, and follow up in various clinir.al settings, but are still subject to some inherent limitations. On important problem may be the interobserver as well as intraobsever variation that may well be present due to the subjective nature of the interpretations. This study was carried out to determine the reliability and reproducibility of visual assessments made in GBPSs, and to observe the degree to vihich the results would be influenced by observer variation. Fiftv two patients with coronary heart disease had resting GBPS and contrast ventriculography v;ithin 4 days appart. Contrast ventriculography showed normal wall motion in 6 patients and the remaining 46 had RWMA in one or more segments. The anterior and left anterolateral views of all 52 GBPSs were analyzed by three independent observers, who selected from 5 scales, their level of confidence that there was RWMA in that segment. Reciever operating characteristic (ROC) curves for each analysis was plotted and the area under the curue (&) was used as a parameter representing each observers perf<nrnance in his interpretations. The findings of contrast ventriculographies were used as the standard for RWMA. The apical and inferoapical segments showed the best correlation with contrast ventriculography (0=-0.90-0.94, 0,81-0,94, respectively), and the inferior wall showed the poorest correlation (0=0,70-0.74), The interpretations of the inferior, septal, apical, and posteroinferior, segments showed no differcnce betsveen the observers, but there was significantly better perfor- mance in assessment by observer A compared to that hy B or C for the anterolateral segments (0=0.87, 0.78, 0,76, respectively. p<0,01 for A vs B, p<0,05 for A vs C), as well as when all segments were considred altogether (0=0,88, 0.83, 0.82, respectively. both p<0 05). This was also true for the infero-apical segment between A and C (0=0.09, 0.81, p<0,05). The intraobsener variation, how- ever, did not appear significant, with only the inferior segment for observer B showing any significant difference when observer A and R repeated the analysis 10 days latter. There was no difference in assessing dyskinesia, with ail observers showing a high performance (0=0.98, 0.87, 0.97, respectively). The visual assessment of left ventricular ejection fraction by all three observers correlated well with the calculated value from a semiautomated method (Spearmans r 0.91, 0.83, 0,83. p<0.01, p<0.05, p<0
99mTc - HMPAO SPECT를 이용한 정상인 국소뇌혈류의 정량적 분석
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),문대혁(Dae Hyuk Moon),궁성수(Sung Soo Koong),노재규(Jae Kyu Roh),명호진(Ho Jin Myung),이범우(Bum Woo Lee),이경한(Kyung Han Lee),최윤호(Yoon Ho Choi),윤병우(Byung Wo 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.2
N/A Regional cerebral perfusion was evaluated in 15 normal controls by single photon emission comput- ed tomography using Tc HM-PAO. For quantitative analysis, 13 pairs of hornologous region of interest (ROI) were drawn on three transverse slices matching the vascular territories and cerebral cortices, and normal values of '3 semiqunatitative indices including Right to left ratio (R/L ratio), 'Regional index' (RI), and 'Region to cerebellum ratio (R/cbll ratio) were calculated. Mean values of R/L ratios of homologous regions were ranged frorn 0.985 to 1.023, and mean +- 2 s.d. of ali regions did not exceed 11% of mean. Significant difference of Rls (mean count per voxel of a ROJ/mean count per voxel of total ROls) between regions were found (p<0.001) with highest values in occipital cortex and cerebellum. After attenuation correction, Rls in deep gray, cranial portion of anterior cerebral artery and vascular territories in the 2nd siice increased significantly (p< 0.05 0.001). hut vise versa in other ROIs. Reginn to cerebellum ratios also showed regional difference siinifar to Rls.