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한약(韓藥) 복합제제(複合製劑)의 투여(投與)가 돼지의 성장(成長) 및 성장(成長)호르몬 분비(分泌)에 미치는 영향(影響)
구본홍,이태업,이병우,Koo Bon-Hong,Lee Tae-Eob,Lee Byung-Woo 대한한방소아과학회 1998 대한한방소아과학회지 Vol.12 No.1
The present study is designed that the herb medicines which are returned to kidney, pancreas and are known by efficacy in growth are supplied to pigs, thereafter the effects to growth and secretion of growth hormone in serum is investigated. For this purpose the 24 days old pigs, which are crossbreeding, castrated are used. The conclusions are that after 4 weeks' supply of herb medicinal compounds, pigs' weight gain has increased in low nutritional group with statistical meaning(p〈0.05). And one day's weight gain has increased with statistical meaning(p〈0.05) in all groups. Regarding food take, the second nutritional group has more significant increase than control group. Utilization rate of nutrition doesn't have any statistical meaning in all groups, but it has the tendency that as herb medicinal compounds are added, utilization rate of nutrition is increased. Increase of vertebra lengths and level of growth hormone in serum according to supply of herb medicinal compound don't have any statistical meaning because of small sample size, but 10 - 20 % increase of vertebra lengths and 10 - 30 % increase of level of growth hormone are observed.
우황포용환(牛黃抱龍丸)이 Rat 및 Mouse의 해열(解熱).진통(鎭通) 진경작용(鎭經作用)에 미치는 영향
원종훈,구본홍,Koo Jong-Hoon,Koo Bon-Hong 대한한방소아과학회 1986 대한한방소아과학회지 Vol.1 No.1
The Woo-Whang-po-Lyong-Whan has been used as one of the traditional medicines in the field of pediatrics so far since Song dynasty, and still it is widely being used nowadays. It might be considered to be a contribution to do further basic experimental studies on antipyretic, anticonvulsive and analgetic action of the Woo-Whang-po-Lyong-Whan. So it's pharmacological studies were carried out comparing to control drugs. ?Following conclusions were obtained. 1. It's antipyretic action was compared to that of aspirin by Writhing response using acetic acid-method. Mice were given one twentith, one tenth and one fifth tablets of the Woo-Whang-po-Lyong-Whan per Kg of body weight, respecitively. Writhing syndrome frequencies were noted as 38.4 in control group. and $18.0{\pm}12$, $13.17{\pm}2.28$, $7.33{\pm}12$ in above esperimental groups, respectively. In aspirin group it was $18.5{\pm}1.0$ when 2mg aspirin per body weight of mice was given. So it was recognized that antipyretic action of the Woo-Whang-Po-Lyong-Whan become remarkable by increasing amounts of the Woo-Whang-Po-Lyong-Whan. ?2. Antipyretic action in normal temperature mice group was not significant by increasing concentration of the Woo-Whang-Po-Lyong-Whan, but body temperature dropping in normal mice group was slightly noted than control. group, but less temperature dropping was noted than aminopyrin group. ?3. In fever provocated rats groups using Salmonella typhimurium, antipyretic action of the Woo-Whang-Po-Lyong-Whan was not observed significantly than control group. And slight antipyretic action was noted in aminopyrin group. So that antipyretic action of the Woo-Whang-Po-Lyong-Whan was not significant than those of general antipyretic used nowadays, but slower action was recognized. ?4. Anticonvulsive action of the Woo-Whang-Po-Lyong-Whan was studies comparing to that of phenobarbital. Action was not remarkable than phenobarbital, but was significant than control group. No significant intesifying action was noted by increasing amounts of the Woo-Whang-Po- Lyong-Whang.
성장치료를 위한 한약투여의 임상적 효과 및 안전성 평가
정정욱,양태규,구본홍,이세연,Cheong, Jeong-Ook,Yang, Tae-Kyu,Koo, Bon-Hong,Lee, Sea-Yun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4
Objective : Recently many studies of herbal medication to promote growth have been implemented. The purpose of this study was to identify the feasibility and safety of herbal medication on short stature. Methods : 143 patients(87 males, 56 Females)who visited with short stature at Kangnam CHA Oriental Hospital From February 1999 to January 2000 and were treated during 6 months, were available for this study. We treated with 5 herbal medications.(Soeumin hyangbujapalmultang-gagambang, Soyangin yukmijihwangtang-gagambang, Taeumin chungsimyunjatang-gagambang, Boa-tang, Boikyangwi tang) At the begining of the treatment and after 6 months treatment, We measured height, weight and body mass index(BMI). And we investigated changes of aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN), alkaline phosphatase(ALP), creatinine. Results: The distribution of ages was from 5 years old to 17 years old. After herbal treatment, mean height, mean weight, mean BMI and mean percentile grade increased $138.5{\pm}15.6$ to $141.9{\pm}15.1$, from $36.9{\pm}13.2$ to $38.9{\pm}13.2$, from $18.5{\pm}3.29$ to $18.7{\pm}3.21$, from $3.2{\pm}1.2$ to $3.4{\pm}1.2$. The contents of AST, ALT, BUN, ALP and Creatinine were not showed any significant change. Conclusions : In the results We recognized Short stature was showed prominent feasibility and safety of herbal medication. Herbal Medication in patients with short stature will improve height velocity without liver and kidney function disorders.
보익양위탕가미방(補益養胃湯加味方)으로 6개월간(個月間) 저신장증(低身長症) 환자(患者)를 치료(治療)한 치험(治驗) 2례(例)
정정욱,양태규,구본홍,이세연,Cheong, Jeong-Ook,Yang, Tae-Kyu,Koo, Bon-Hong,Lee, Sea-Yun 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4
IShort stature is two standard deviations (SD) below the mean for height (below the third percentile) in a population of children. We treated two cases below the third percentile for height with Boikyangwitang-gamibang(補益養胃湯加味方). During treatment Case I grew 4.2cm and became above the third percentile for height. Case II also grew 5.8cm and became above the third percentile for height. In the results We recognized Short status was showed prominent improvement with Boikyangwitang-gamibang(補益養胃湯加味方).
생약복합제제의 약효연구(제36보) : 십미도적산이 중추신경계 및 순환기계에 미치는 영향
홍남두(Nam Doo Hong),구본홍(Bon Hong Koo),주수만(Soo Man Joo),이성규(Sung Kyu Lee) 한국생약학회 1988 생약학회지 Vol.19 No.2
The sedative, antipyretic, analgesic and anticonvulsive action, action on the isolated ileum in mice, retricting action on edema, action on blood pressure and respiration of Sipmidojuksan were evaluated. The results were as follows: sedative effects were recognized by the unbalanced effects of spontaneous momentum by wheel cage method, muscle relaxing action by rotor rod method and prolongation of sleeping hours. In mice, a significant antipyretic effect to endotoxin was recognized. Significant anagesic effects by acetic acid and Randall-Sellito method were recognized. Significant anticonvulsive effects to strychnine and picrotoxin were recognized. Spontaneous momentum of isolated ileum in mice was restricted, and relaxing effects on smooth muscle of digestive organ were noted by anti-acetylcholine, anti-barium chloride and anti-histamine effects. Significant antiedemic effects to carrageenin and histamine were recognized. Dilatation of blood vessels and decrease of blood pressure were noted.