원발개방각녹내장 환자에서 일차 치료 방법에 따른 비용과 분포 비교

곽동윤,곽지현,김연덕,임혜빈,백혜정,박치준,AmanShahB.AbdulMajid,강규동 대한안과학회 2010 대한안과학회지 Vol.51 No.6

Purpose: To perform an economic evaluation of the different treatment methods available for primary open-angle glaucoma in a Korean setting, including medication, selective laser trabeculoplasty, or surgery. Methods: Three independent Markov chains were constructed for each treatment option to simulate treatment progress and to evaluate the total treatment costs for each initial strategy. The Markov chain consisted of different stages (5, 10, 20 stages), with each stage being one year. Assuming 1000 patients, a Monte Carlo simulation was iterated 1000 times to evaluate the cost of treatment over 5, 10 and 20 years. Results: During the initial five years, medication as the initial treatment was the most expensive, whereas laser trabeculoplasty was the cheapest. After ten years, surgery became the cheapest treatment. In ten years, if the success rate of surgery is greater than 30.1%, it was more economic to choose surgery as the initial treatment. For laser trabeculoplasty, if the success rate was greater than 16.3%, laser treatment was more economical than was medication. Our model shows that only if the annual cost of medication decreases to 60,000 won or 55,000 won, then the cost of choosing medication as the initial treatment strategy will be more economical than that of laser therapy or surgery, respectively. Conclusions: The economic value of choosing laser therapy as the initial treatment strategy is the greatest over five simulated-years, whereas surgery had the greatest economic value over more than ten years. J Korean Ophthalmol Soc 2010;51(6):865-874

일본의 광역 도시경관행정에 관한 연구 -都道府縣의 경관시책을 중심으로-

곽동윤,이영석 대한국토·도시계획학회 2002 國土計劃 Vol.37 No.2

및 평가이상 일본 광역지자체인 이와떼현, 사이타마현, 나가노현의 경관행정 및 그 시책에 대해 검토하였다.

조선 산업에 있어서 디자인과 Co-work Process개발에 관한 연구

곽동윤,유상욱 한국기초조형학회 2015 기초조형학연구 Vol.16 No.3

The Republic of Korea entered world shipbuilding market in the 1970s, emerge as the world's No. 1 shipbuilding in the short term. but now the world market is losing initiative to China. corresponding to the chase of a second-tier rivals and formation of a huge new market of high-speed ship and a luxury cruise ship part, In order to keep predominance continually in the Shipbuilding industry have to develop the sophistication of shipbuilding industry and high-added value technology vessel is required. Accordingly, we look for ways to strengthen the competitiveness of Korea's shipbuilding industry through the trends of the global shipbuilding industry. Although Investment comparison yield effect is very high design's participation rate is low in the shipbuilding industry. so through appropriate and effective convergence the Co-work process was developed to secure competitiveness through comparative and analysis in differences of the ship design process and design process. the Co-work Process Developed through this research is comprehensive process as active as introduction on design field. and it is logical consequence for communicating with two sector. and the process can flexible response according to the type of ship. This study is an essential requirement in the future of Korea's shipbuilding industry is necessary to develop an ongoing basis. so it will make efforts to further develop through the empirical verification through continuous research. 대한민국은 1970년대 세계 조선시장에 진출하여 짧은 기간에 세계1위의 조선강국으로 도약하였으나 세계시장의 주도권을 중국에 빼앗기고 있다. 조선해양산업에 있어 계속적인 우위를 지키기 위해서는 후발경쟁국의 추격과 초고속, 호화유람선 부분의 거대한 신규시장 형성에 대응한 조선 산업의 고도화 및 고부가가치 선박의 기술개발이 요구되고 있다. 이에 따라 세계 조선 산업의 동향 파악을 통해 한국의 조선 산업 경쟁력강화를 위한 방법을 모색하였다. 투자대비 산출효과가 매우 높지만 조선 산업 참여도가 낮은 디자인을 조선 산업에 접목하여 경쟁력을 확보하고자 선박설계에 사용되는 프로세스와 디자인프로세스의 비교 분석을 통해 각 프로세스의 차이점을 인식하고 적절한 융합을 통해 효과적인 Co-work프로세스를 개발하였다. 본 연구를 통해 개발한 Co-work Process는 디자인 분야가 적극 도입된 종합적 프로세스이며, 두 분야의 의사소통을 위한 논리적인 결과를 가지며 선종에 따른 유연한 대응이 가능한 프로세스이다. 이러한 연구는 앞으로 한국의 조선 산업이 지속적으로 발전해 나가는데 필요한 필수적 요건이며, 지속적 연구를 통한 실증적 검증을 거쳐 더욱 발전시켜나가야 할 것이다.

일본 도시경관관련의 최근 동향

곽동윤 대한국토·도시계획학회 2005 도시정보 Vol.- No.277

(주)에스앤디

곽동윤,변정희 한국식품저장유통학회 2022 식품저장과 가공산업 Vol.21 No.1

일본 정령지정도시의 도시경관행정에 관한 연구

곽동윤,기타하라 토시오 대한국토·도시계획학회 2003 國土計劃 Vol.38 No.4

홍화 ( Carthamus tinctorius L ) 씨의 열수 추출물을 이용한 쿠키제조특성과 관능평가

곽동윤,임정호,김종국,최명숙,문광덕 한국식품과학회 1999 한국식품과학회 학술대회 Vol.1999 No.1

일본 지방도시 사와라시(佐原市)의 역사경관재생을 통한 중심시가지 재생전략과 방안­ 지역관리조직의 역할과 기능을 중심으로 ­

곽동윤 대한국토·도시계획학회 2006 國土計劃 Vol.41 No.7

In the middle of 1990's, the continuous declination of city center has ignited serious discussions on the city center revitalization in Korea. Then after, local cities are searching for various revitalization strategies through administrative support or independent revitalization plans, however, adequate solution is not found. One of that reasons is that these revitalization plan don't consider the local cultural need in planning and design. In Japan, to solve the decline of city center due to reducing number of visitors, various town revitalization strategies are planned from time to time. This study analyzes the town revitalization process of historic city of Sawara. The purpose of this study is to consider roles and a function of Town Management Organization that is a driving force in the town revitalization, and propose applications of such town revitalization in Korea. For local city revitalization strategies in Korea, This study suggests the followings were; 1) Town revitalization policy in connection with local townscape revitalization policy, 2) Town Management Organization system as a comprehensive intervention, 3) Planning of multi-lateral committee system.키 워 드 역사경관, 중심시가지, 주민참여, 지역관리조직, 재생Keywords Historical Townscape, City Center, Citizen Participation, Town Management Organization,Revitalization

표재성방광암에서 Survivin과 p53 발현의 임상적 의의

곽동윤,하지용,장혁수,최미선,박철희,김천일 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.1

Purpose: The prognostic value of p53 remains controversial in transitional cell carcinomas of the bladder. Survivin, an inhibitor of apoptosis, is expressed in many human cancers. Recent studies have reported increased expression of survivin in superficial transitional cell carcinomas of the bladder. We investigated the expression of survivin and p53 and the clinical implications of this expression in superficial transitional cell carcinomas of the bladder. Materials and Methods: Immunohistochemical staining of paraffin sections using a monoclonal antibody for survivin and p53 was performed in 82 cases of superficial transitional cell carcinomas of the bladder. Correlations between the expression of survivin and p53 and clinicopathological features, such as age, multiplicity of tumor, size, recurrence, and progression, were examined. Results: Among 82 cases, positive survivin expression(greater than 20%) was observed in 59 cases. Positive p53 expression(greater than 20%) was observed in 46 cases. There were no significant differences in age, gender, multiplicity, tumor size, tumor grade, pT stage, recurrence, or progression-free survival between p53-positive and p53-negative groups(p>0.05). Also, there were no significant differences in age, gender, multiplicity, tumor size, tumor grade, or pT stage between survivin-positive and survivinnegative groups(p>0.05). However, recurrent-free and progression-free survivals were significantly lower in the survivin-positive group than in the survivin-negative group(p<0.05). Conclusions: The expression of survivin can be recommended as a useful marker for predicting disease recurrence and progression. Survivin may be superior to p53 as a prognostic factor in superficial transitional cell carcinoma of bladder. Purpose: The prognostic value of p53 remains controversial in transitional cell carcinomas of the bladder. Survivin, an inhibitor of apoptosis, is expressed in many human cancers. Recent studies have reported increased expression of survivin in superficial transitional cell carcinomas of the bladder. We investigated the expression of survivin and p53 and the clinical implications of this expression in superficial transitional cell carcinomas of the bladder. Materials and Methods: Immunohistochemical staining of paraffin sections using a monoclonal antibody for survivin and p53 was performed in 82 cases of superficial transitional cell carcinomas of the bladder. Correlations between the expression of survivin and p53 and clinicopathological features, such as age, multiplicity of tumor, size, recurrence, and progression, were examined. Results: Among 82 cases, positive survivin expression(greater than 20%) was observed in 59 cases. Positive p53 expression(greater than 20%) was observed in 46 cases. There were no significant differences in age, gender, multiplicity, tumor size, tumor grade, pT stage, recurrence, or progression-free survival between p53-positive and p53-negative groups(p>0.05). Also, there were no significant differences in age, gender, multiplicity, tumor size, tumor grade, or pT stage between survivin-positive and survivinnegative groups(p>0.05). However, recurrent-free and progression-free survivals were significantly lower in the survivin-positive group than in the survivin-negative group(p<0.05). Conclusions: The expression of survivin can be recommended as a useful marker for predicting disease recurrence and progression. Survivin may be superior to p53 as a prognostic factor in superficial transitional cell carcinoma of bladder.

용적이 큰 전립선비대증에서 경요도전립선절제술의 효용성과 안전성: 장기추적결과

곽동윤,장혁수,박철희,김천일 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.1

Purpose: We compare the effectiveness and safety of transurethral resection of the prostate(TURP) with those of open prostatectomy for large benign prostatic hyperplasia(BPH), that was over 70cc of prostate volume. Materials and Methods: Seventy-one patients with a prostate volume of more than 70cc and who received TURP were classified to group A, while 41 patients who received open prostatectomy were classified to group B. The International Prostate Symptom Score(IPSS), maximal flow rate(Qmax) and post-voiding residual urine(PVR) volume were evaluated preoperatively and at 1, 3, 5 and over 5 years postoperatively. Results: The postoperative IPSS, Qmax and PVR were significantly improved after 1 year(p<0.05). The IPSS and Qmax showed no significant differences between the two groups for 1, 3, 5 and over 5 years after operation(p>0.05). The PVR was significantly lower in group B at 1 year post-operation(p<0.05), but there were no significant difference between the groups for 3, 5 and over 5 years after operation(p>0.05). There were 7 cases(9.8%) of re-operation and 3 cases(4.2%) of re-medication after 5 years of operation. There were no major complications for each group. Conclusions: On comparison between TURP and open prostatectomy for the patients with large BPH, there were no significant difference in effectiveness and safety for 5 years. Even for the patients with BPH that showed a high volume, TURP is an effective operation that can replace open prostatectomy. (Korean J Urol 2008;49:31-36) Purpose: We compare the effectiveness and safety of transurethral resection of the prostate(TURP) with those of open prostatectomy for large benign prostatic hyperplasia(BPH), that was over 70cc of prostate volume. Materials and Methods: Seventy-one patients with a prostate volume of more than 70cc and who received TURP were classified to group A, while 41 patients who received open prostatectomy were classified to group B. The International Prostate Symptom Score(IPSS), maximal flow rate(Qmax) and post-voiding residual urine(PVR) volume were evaluated preoperatively and at 1, 3, 5 and over 5 years postoperatively. Results: The postoperative IPSS, Qmax and PVR were significantly improved after 1 year(p<0.05). The IPSS and Qmax showed no significant differences between the two groups for 1, 3, 5 and over 5 years after operation(p>0.05). The PVR was significantly lower in group B at 1 year post-operation(p<0.05), but there were no significant difference between the groups for 3, 5 and over 5 years after operation(p>0.05). There were 7 cases(9.8%) of re-operation and 3 cases(4.2%) of re-medication after 5 years of operation. There were no major complications for each group. Conclusions: On comparison between TURP and open prostatectomy for the patients with large BPH, there were no significant difference in effectiveness and safety for 5 years. Even for the patients with BPH that showed a high volume, TURP is an effective operation that can replace open prostatectomy. (Korean J Urol 2008;49:31-36)