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정신분열증에서 전반적 장애수준에 영향을 미치는 증상에 관한 연구
고문경,신석철,왕성근 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
This study was attempted to clarify the effects of the symptoms which determine the overall evel of disability after twelve months among various aspects of short-term prognosis in schizo phrenia. 100 Schizophrenic patients on Screening Schedule were applied Present State Examination, Psychological Impairment Rating Schedule, Scale for the Assessment of Negative symptoms and Diagnostic and Prognostic schedule. Overall level of disability after twelve months was classified in 3 groups as the group of improvement with less disability(56 patients), the group of no change(21 patients), and the group of deterioration with more disability(23 patients). To investigate differentiating components among 3 groups, the autlor selected 25 significant variables(p<0.005)with the X^2-test of independence and then tried factor analysis using SPSS/ PC+ based on the scores of each variable. The results of factor analysis were as follows. 1. In the group of improvement with less disability, 2 factors were extracted as lack of emotion factor and poverty of content of speech factor. In the group of no change, 3 factors were extracted as lack of emotion factor, lack of interest factor and poverty of content of speech factor. In the group of deterioration with more disability, 4 factors were extracted as lack of emotion and abnormal expression factor, lack of interpersonal relationship factor, lack of selfinterest factor and poverty of content of speech factor. 2. In the group of improvement with less disability, the contents of lack of emotion factor and poverty of content of speech factor were consistent with the contents of the factor extracted in the other 2 groups, but the severity of the symptoms was minimal and the symptoms of lack of interest or lack of interpersonal relationship were not revealed 3. In the group of no change, the contents of lack of emotion factor and poverty of content of speech factor were consistent with the contents of the factors extracted in the other 2 groups, but the severity of the symptoms was moderate and the contents of lack of interest was characteristic additional symptoms. 4. In the group of deterioration with more disability, the contents of lack emotion factor and poverty of content of speech factor were consistent with the contents of the factor extracted in the other 2 groups, but the severity of the symtoms was severe. The contents of lack of selfinterest factor were consistent with the contents of the factor extracted in the group of no change but the severity of the symptoms was severe. And the contents of lack of interpersonal relationship and abnormal expression were characteritsic additional symptoms.
제비꽃속 제비꽃아절의 유전적 다양성과 RAPD 분석에 의한 계열별 marker의 개발
진연희,오병준,이철희,고문경 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 1996 연구보고서 Vol.1 No.-
제비꽃아절에 속하는 종들의 유전적 근연관계를 구명하기 위하여 30 종류의 종들과 그들의 교잡종을 사용하여 RAPD 분석을 실시하였다. 선발된 13개의 primers는 56개의 informative marker를 증폭하였으며, 이를 바탕으로 UPGMA 분석을 하여 Group A와 B로 집괴하였다. 제비꽃계열에 속하는 대부분의 종들(19종)과 남산제비꽃계열에 속한 남산제비꽃이 A그룹에 속했으며, A그룹은 A-Ⅰ, A-Ⅱ, A-Ⅲ의 3개의 아그룹으로 구분되었다. 이 dendrogram을 분석한 결과 각각의 아그룹들은 어느 정도 형태적인 특성과 일치하였다. 그러나 형태적 분류에 의해서는 다른 계열에 속하는 태백제비꽃, 단풍제비꽃과 남산제비꽃은 높은 유사도지수를 보이며 아그룹 A-Ⅲ에 함께 집괴되었다. 알록제비꽃계열에 속하는 7종류의 식물들과 뫼제비꽃계열에 속하는 자주잎제비꽃은 B그룹으로 집괴되었다. 화업제비꽃과 자주잎제비꽃의 양친을 구명하기 위하여 선발된 10개의 random primers로 RAPD 분석을 하여 44개의 informative bands를 얻었다. 이를 바탕으로 한 UPGMA 분석의결과 화업제비꽃은 자주잎제비꽃의 한쪽친으로 생각되는 남산제비꽃과 상대적으로 높은 유사도지수를 보였다. 또한 제비꽃과 호제비꽃 중의 하나가 화업제비꽃이나 자주잎제비꽃의 한쪽친인 것으로 생각된다. RAPD 분석에 의한 제비꽃속 식물의 유전적 분류는 전통적인 방법인 형태적 특성에 의한 분류와 대체적으로 일치하는 경향이었다 The genetic relationships of Viola in the Subsection Patellares were analyze using random amplified polymorphic DNA (RAPD) method. A total of 56 PCR products amplified by 13 random primers were used to perform for the cluster analysis with UPGMA. Nineteen Viola from the series Chinensis and V. chaerophylloides from the series Pinnatae were clustered into group A, and were subdivided into subgroups, A-Ⅰ, A-Ⅱ, and A-Ⅲ. Each subgroups to some extent corresponding to morphological characteristics were readily distinguished on this dendrogram. However, V. albida, V. albida var. takahasii, and V. chaerophylloides were clustered into A-Ⅲ with a high similarity coefficient, although they are classified into different series by morphological characteristis. Seven Viola species in he series Variegatae and V. violacea in the series Patellares were clustered into group B. In order to deduce putative parents of V. ibukiana and V. vioacea, ten primers selected from the previous study amplified 44 informative polymorphic products. From the cluster analysis, V. ibukiana had a relative high similarity coefficienct with V. chaerophylloides which might be one of putative parents of V. violacea. One of V. mandshurica and V. yedoensis may serve as another putative parents of V. ibukiana and V. violacea. Genetic relationships of Viola derived using data from RAPD analysis might be in agreement with conventional taxonomy from morphological characteristics
고문경,신석철 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.3
In order to differentiate the deficits of attention and cognitive function between schizophrenia and organic brain syndrome, the author tested simple visual reaction time and mini-mental state for 30 schizophrenics, 30 patients with organic brain syndrome and 30 controls who were matched for age and sex with the schizophrenic group. These patients hand been admitted to Neuropsychiatric ward of Chungnam National University Hospital and were selected by research criteria of Feighner et al. The data were statistically analysed and the results were obtained as follows. 1. Reaction time of the patients with organic brain syndrome was slower than that of the schizophrenics. And reaction time of the schizophrenics was slower than that of the controls. 2. The score of mini-mental state of the patients with organic brain syndrome was lower than that of the schizophrenics. And the score of mini-mental state of the schizophrenics was lower than that of the controls. 3. Both the organic brain syndrome and the control groups showed significant negative correlation between reaction time and score of mini-mental state but schizophrenic group didn't show the correlation.