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강호림,In-Kyu Park,Na-Ri Shin,유한상,Toshihiro Akaike,조종수 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.3
Chitosan microspheres were prepared by ionic gelation process with sodium sulfate for nasal vaccine delivery. Bordetella Bronchiseptica Dermonecrotoxin (BBD) as a major virulence factor of a causative agent of atrophic rhinitis (AR) was loaded to the chitosan microspheres for vaccination. Morphology of BBD-loaded chitosan microspheres was observed as spherical shapes. The average particle sizes of the BBD-loaded chitosan microspheres were about 2.69 mm. More BBD was released with an increase of molecular weight of chitosan and with an increase of medium pH in vitro due to weaker intermolecular interaction between chitosan and BBD. Tumor necrosis factor-a (TNFa) and nitric oxide (NO) from RAW264.7 cells stimulated with BBD-loaded chitosan microspheres were gradually secreted, suggesting that released BBD from chitosan microspheres had immune stimulating activity of AR vaccine.
강호림,Seog-Jin Seo,Takashi Hoshiba,Toshihiro Akaike,조종수 한국생체재료학회 2008 생체재료학회지 Vol.12 No.3
Galactose moiety was covalently coupled with chitosan to improve hepatocyte adhesion and heparin was immobilized to the galactosylated chitosan (GC) to enhancing hepatocyte function. Hepatocyte adhesion to heparin immobilized GC (GCH)-casted polystyrene (PS) dish was higher than that to chitosan-casted PS dish although it was slightly lower than GC-casted PS dish owing to the hydrated GCH-casted PS dish. Spreading of hepatocytes attached onto GCH-casted PS dish was increased with an increase of heparin for the GCH in the presence of hepatocyte growth factor (HGF). Also, DNA synthesis of the hepatocyte adhered to GCH-casted PS dish was increased with an increase of heparin in the GCH. Higher levels of albumin secretion were maintained on the GCH-casted PS dish than chitosan- or GC-casted PS dishes.