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- 저자 : 강형철 ( So Yun Cho (검색결과 4 건)
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조소연,강형철 ( So Yun Cho,Hyung Chul Kang ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4
Background: Vitiligo is a distressing skin condition in which acquired destruction of melanocytes causes depigmented patches of various shapes & sizes by as yet unclear mechanisms. Its classification is as varied and unresolved as the theories on its pathogenesis, the most plausible of which are autoimmune, neurohumoral and self-destruction theories. Objective . Our purpose was to devise a classification scheme which would correlate well with the disease course and prognosis. Method: We classified vitiligo into 3 types(symmetric: type 1, segmental; type 2, localized; type 3) based on different proposed pathogenetic mechanisms and analyzed the differences between these types in the clinical manifestations of 502 Korean cases. Results : 1. There were 203 males(40.4% ) and 299 females(59.6%). 2. The most frequent clinical type was the symmetric type(49.8%), followed by the localized type(34.1%) and the segmental type(16.1%). 3, The male-to-female ratio was highest in type 2, but not significantly so. 4. Poliosis and halo nevus were associated in 22.3% and 3.8%, respectiuely. 5. The mean age at the first visit was 32.7 years(male, 29.2 years, female; 27.5 years), and there was a significant difference between the clinical types(type 1; 41.0 years, type 2; 20.5 years, type 3; 26.2 years). 6. The mean age of onset was 25.6 years(male; 23.0 years, female; 27.5 years), and there was a significant difference between the clinical types(type 1; 31.3 years, type 2; 15.7 years, type 3; 22.1 years). 7. A family history of vitiligo was observed in 11.2% of patients, whose sisters were most frequently affected, and there was no significant difference between the clinical types. 8. Associated diseases were seen in 12.1% of the patients, the frequency of which was significantly higher in type 1 vitiligo. 9. Abnormal laboratory findings were found in 14.7% and were significantly more common in type 1 vitiligo. Conclusions . The 3 types differ significantly in the mean age at the first visit, the mean age of onset, disease association and abnormal laboratory findings. Type 1 develops by autoimmune mechanisms, as shown by the continuous progression and the close association with other diseases and abnormal laboratory findings, Types 2 and 3 have a different disease course, becoming stationary after initial progression, Thus, the 3 clinical types classified by the authors are thought to be useful in predicting the course and prognosis of vitiligo and in determining the appropriate therapy. For a more optimal classification, further study on the pathogenesis of vitiligo seems to be in order. (Kor J Dermatol 1997;35(4): 827-637)
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이민재,임연순,조소연,강형철,함정희 梨花女子大學校 醫科大學 醫科學硏究所 1994 EMJ (Ewha medical journal) Vol.17 No.2
Merkel cell carcinoma is a rare aggressive tumor of uncertain origin. The tumor occurres most commonly in the head and neck region of the eldery. The patient was a 62-year-old female with a reddish nonulcerative movable hard nodule on her left temple area for 2 months. Histopathologically, the tumor cells with large vesicular nuclei and scanty cytoplasm were arranged in trabecular and cord-like pattern in the dermis. The majority of the tumor cells were positive for neuron specific enolase, chromogranin and neurofilament.
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Interferon-a 치료로 호전을 보인 소방성 혈관종 1예
김지현,김연진,함정희,이미애,강형철,조소연 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.3
A 13-month-old boy had irregularly shaped, erythematous to dusky red, slightly raised patches and plaques on the left antecubital fossa and arm for 7 months. The lesions were firm and tender. Histopathologically the lesion consisted of small, circumscribed, angiomatous tufts and lobules with a cannonball appearance scattered throughout dermis, a characteristic feature of tufted angioma. For 15 weeks, interferon-a intralesional injections have been performed and the lesions showed an improvement.
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