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Itraconazole 치료 중 발생한 급성 전신성 발진성 농포증 1예
강민철 ( Min Chul Kang ),김성애 ( Sung Ae Kim ),이규석 ( Kyu Suk Lee ),조재위 ( Jae We Cho ) 大韓皮膚科學會 2009 大韓皮膚科學會誌 Vol.47 No.9
A 40-year-old male had a history of tinea pedis, which had been treated with itraconazole. One week later fever and pruritic, multiple, symmetric, erythematous papules developed, some of which became confluent, producing plaques on his face, trunk, and limbs. The skin biopsy showed subcorneal and spongiform pustules. One month later we had patch tests with itraconazole and other drugs. The result of the patch test using itraconazole was a (++) reaction that showed erythematous macules, papulovesicles and patch (after 48 hours). So, we report here a rare case of acute generalized exanthematous pustulosis (AGEP) that manifests as generalized erythema, erythema multiforme and amicrobial pustules with fever due to itraconazole. (Korean J Dermatol 2009;47(9):1098∼1101)
강민철 ( Min Chul Kang ),박영도 ( Young Do Park ),이규석 ( Kyu Suk Lee ),정상립 ( Sang Lip Chung ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Dematomyositis is an idiopathic inflammatory myopathy characterized by specific skin manifestations and progressive symmetric proximal muscle weakness. Importantly, dermatomyositis is occasionally associated with the internal malignant tumor, which is clearly correlated with poor prognosis. We report two cases of dermatomyositis, showing characteristic skin lesions, that associated with small cell lung cancer in a 64-year old man and gallbladder cancer in a 54-year old man, respectively. On laboratory findings muscle enzymes and liver function markers were elevated prominently. We tried to treat these patients with systemic corticosteroid and chemotherapy. The patient with small cell lung cancer died of SAH due to head trauma and in the case of the patient with gallbladder cancer, the symptoms of the muscle weakness and the skin lesions are getting better and worse repeatedly fluctuating and regular periodic follow up is required. (Korean J Dermatol 2008;46(8):1069~1074)
강민철 ( Min Chul Kang ),김성애 ( Sung Ae Kim ),이규석 ( Kyu Suk Lee ),조재위 ( Jae We Cho ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.12
Fluorescein has been used for decades in ophthalmology for fluorescence angiography and it is the only fluorophore routinely used in experimental dermatology for in vivo study of the skin. It absorbs blue light, with peak absorption and excitation wavelengths between 465 and 490 nm and fluoresces at yellow-green wavelengths of 520∼530 nm. The most common side effects are nausea and vomiting, and other adverse events such as a vasovagal response, cardiac or respiratory effects, neurologic manifestations or allergy, including anaphylaxis, were also reported. But a photosensitive reaction to fluorescein is very rare. We report here on a case of photoallergic dermatitis due to fluorescein after fluorescence angiography. (Korean J Dermatol 2009;47(12):1368∼1370)
강민철 ( Min Chul Kang ),김성애 ( Sung Ae Kim ),정상립 ( Sang Lip Chung ),이규석 ( Kyu Suk Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6
Silmazine(R) cream is an antibiotic agent widely used in burn therapy. It consists of Propylene glycol, Stearyl alcohol, Isopropyl Myristate, Sorbitan mono-oleate, Methyl-p-hydroxybenzoate, Polyoxyl 40 stearate and varseline. A 24-year- old female presented with well-demarcated erythematous papules and vesicles with an itching sensation on the dorsal area of her right hand. She had applied Silmazine(R) cream on the dorsal area of her right handfor 4 days and the skin lesion became aggravated. A patch test with Silmazine(R) cream `as is` showed a positive reaction and propylene glycol and stearyl alcohol, ingredients in Silmazine(R) cream, revealed a positive reaction. These two agents are known as weak sensitizers that can produce allergic contact dermatitis. There are some reports of allergic contact dermatitis from propylene glycol and stearyl alcohol used topically. As far as we know, there are no reports of allergic contact dermatitis from propylene glycol and stearyl alcohol in the Silmazine(R) cream (Silver sulfadiazine) that is commonly used as topical antibiotic medication for burns. We report this rare case of allergic contact dermatitis from propylene glycol and stearyl alcohol in Silmazine(R) cream (Silver sulfadiazine). (Korean J Dermatol 2009;47(6):710∼713)
기동특성 및 효율 향상을 위한 Single-Phase LSPM의 회전자 형상 설계
강민철(Min-Chul Kang),조광진(Kwang-Jin Cho),김규탁(Gyu-Tak Kim) 대한전기학회 2016 전기학회논문지 Vol.65 No.1
In this paper, the design of rotor shape was performed for improvement of start-up characteristics and efficiency in single-phase LSPM. In order to improve the start-up characteristics, shape of rotor aluminium cage bar was changed. Through arrangement of permanent magnets and installation of flux barriers, it was performed torque ripple reduction and efficiency improvement. Cogging torque and back-EMF is calculated by the no-load analysis, start-up time is calculated by the start-up state analysis, efficiency and torque ripple is calculated by steady state analysis. The characteristics of the motor were calculated through FEM.
자외선 B 조사한 HaCaT 세포에서 세포자멸사 관련 유전자 발현
강민철 ( Min Chul Kang ),이규석 ( Kyu Suk Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.7
Background: Ultraviolet B (UVB) radiation is a major harmful environmental factor causing cutaneous changes such as sunburn, skin aging and skin cancer. Excessive UVB irradiation induces apoptosis of keratinocytes through several molecular pathways. However, the precise molecular mechanisms have been underinvestigated. Objective: The purpose of this study was to investigate expression levels of apoptosis-related genes in UVB-irradiated HaCaT ketratinocyte cell lines. Methods: Cells were irradiated by UVB at various doses (0, 100, 200 and 400 mJ/cm2). Expression levels of caspases, Bax, Bcl2, and Bcl-X(L) were confirmed by RT-PCR analysis and western blotting. Results: Expression of cytochrome C was increased followed by activation of caspase-3, 8 and 9 in UVB-irradiated HaCaT cells. Furthermore, the expression of Bcl-X(L) was decreased from UVB 200 mJ/cm2 and Bcl2 was decreased weakly from UVB 400 mJ/cm2, implying that the expression of Bcl-X(L) is more sensitive to UVB. Interestingly, the down-regulation of Bcl-X(L) may be mediated by proteasome dependent pathways. Conclusion: Excessive UVB-irradiated HaCaT cells undergo apoptotic cell death following activation of caspases; degradation of Bcl-X(L) is particularly sensitive to UVB. (Korean J Dermatol 2009;47(7):790~797)
강민철(Kang, Min-chul),박은정(Park, Eun-jung),김은하(Kim, Eun-ha) 한국웰니스학회 2016 한국웰니스학회지 Vol.11 No.4
본 연구의 목적은 자기비난이 자살사고에 미치는 영향에 있어 내면화된 수치심과 우울의 매개효과를 검증하는데 있다. 본 연구는 특히 내면화된 수치심에 초점을 맞추어 내면화된 수치심이 자기비난, 우울, 자살사고와 관련하여 어떠한 역할을 하고 그 중요성이 어떠한지를 면밀히 살펴보고자 하였다. 이를 위해 대학생 343명에게 설문을 배포하고, 이 중 329명의 자료를 구조방정식모형을 통해 분석하였다. 분석결과 첫째, 자기비난이 내면화된 수치심을 통해 우울에 미치는 구조모형을 분석한 결과 완전매개모형이 채택되었으며, 내면화된 수치심은 자기비난이 우울에 미치는 영향을 유의하게 매개하였다. 둘째, 내면화된 수치심이 자살사고에 미치는 직접효과를 통제하였을 때 우울은 자살사고에 유의한 영향을 미치지 못하였으나, 내면화된 수치심은 자기비난이 자살사고에 미치는 영향을 유의하게 매개하였다. 연구결과에 따른 시사점과 제한점 및 후속연구에 대한 제언을 논의하였다. The aim of the present study was to test the mediating effects of internalized shame and depression in the relationship between self-criticism and suicidal ideation. This study focused, in particular, on the role of internalized shame in the relationship among self-criticism, depression, and suicidal ideation. For this, a questionnaire was distributed to 343 university students and 329 data were analyzed using structural equation modeling. The results were as follows: First, as the results of analyzing the pathway that self-criticism has impact on suicidal ideation via internalized shame, the model which assumes full mediation was adopted and internalized shame significantly mediated the relationship between self-criticism. Second, the effect of depression on suicidal ideation was not significant when controlling for the direct effect of internalized shame on suicidal ideation while internalized shame significantly mediated the relationship between self-criticism and suicidal ideation. Limitations, implication, and future directions of this study were discussed.
강민철(Min-chul Kang),김현식(Hyun-sik Kim),김대업(Dae-up Kim) 한국자동차공학회 2003 한국자동차공학회 지부 학술대회 논문집 Vol.2003 No.10
Magnesium alloys are attractive candidates for automotive applications due to high stiffness and damping capacity. Recently, various approaches have been investigated for improving the ductility and creep resistance. Most of the major uses of magnesium in automobiles were developed and promoted by engineers and designers for steering column housing, cylinder head cover, instrument panel, etc. The object of this study was to review the application for automotive parts of Korea, Japan, westem Europe, north America, and China.