胃의 癌 및 良性 疾患에 있어서 胃粘膜의 細胞學的 診斷

姜大榮 충남대학교 대학원 1976 論文集 Vol.6 No.-

In order to evaluate cytologic diagnosis in benign and malignant lesions in the stomach 91 unfixed gastrectomized specimen were studied, which were submitted to department of pathology, Chungnam National University School of Medicine from January 1975 to September 1975 The cytologic smears were taken from central portions and margins of the ulcer of the lesions, and compared with that of histologic pattern with clinical considerations The results obtained were as follows 1) 91 cases were consisted of 40 carcinomas (44.0%), 39 benign peptic ulcers(42.9%) and 12 gastritis wth other diseases (13.%) 2) Among gastric carcinomas there were noted 4 early gastric cancers originated from primary chronic peptic ulcers, which were not detected clinically 3) Sec distr bution of stomach cancr was 20 malse (65%), and 14 females (35%) having 1 9 ratio Age distribution of stomach cancer was showing the highest in 6th decade, 23 cases (57.5%), 5th decade, 10 cases (25.0%) and more than 80% were noted from 40 year to 60 year-old age groups 4) Sex distribution of chronic peptic ulcer was consisted mainly of male cases showing 37 cases of a total 39 patients (94.9%) Age distribution was the highest in both 4th decade 12 cases (30.8%) and 12 cases(30.8%) in 5th decade 5) The average diameter of malignant ulcers was 3.0-3.9 ㎝ in 14 cases (35.0%), and 6 cases were mort than 5.0㎝ in diameter In benign peptic ulcer mose frequent average size was 1.0-1.9 ㎝ in 16 cases (41.0%)and there was no case meauring over 5.0 ㎝ in diameter 6) The most malignant ulcers were located along the lesser curvature of the antrum in 33 cases (82.5%), and 5 cases (12.5%) were along the greater curvature of the stomach The peptc ulcers also, were located most frequently along the lesser curvature of the antrum in 32 cases (82.1%). 7) Cytologic diagnosis smeared from center and margins of the malignant ulcers was positive in 85%, but that smeared from peripheral portions of the lesion was positive only in 27.5% of cases. 8) The positive diagnosis in well differentiated and moderately differentiated type of the stomach cancer was 100%, and showed one case of pseudonegative in 18 cases of poorly differentiated type 9) The doutful cytological diagnosis in chronic peptic ulcers was 16 cases (41.0%), and those were associated with chronic gastritis or with marked inestinal metaplasia with atypical glandular hyperplasia.

忠南地方에 있어서 唾液腺 腫瘍의 病理組織學的 硏究

姜大榮,李載欣 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

For studies on salivary gland tumors in the Chungnam areas, the specimens were collected at the department of pathology, Chungnam National University School of Medicine from January 1972 to September 1983, and a statistical analysis on clinical or histological basis was made on 96 cases of salivary gland tumors. The results were as follows: 1. Out of 96 cases, 80 cases(83.3%) occurred at the salivary glands, in order of parotid gland in 54 cases (67.5%), submandibular gland in 25 cases (31.3%) and sublingual gland in 1 case (1.2%). Among minor salivary gland tumors, palate gland was the most favorite site with 10 cases (75%) out of 16. 2. Out of 96 cases, 82 cases (85.4%) were benign and 14 cases (14.6%) were malignant. Most common benign tumor was pleomorphic adenoma in 78 cases(85.1%), while mucoepidermoid carcinoma or adenoid cystic carcinoma in 4 cases (28.6%) was most common malignant tumor. 3. Overall sex distribution of salivary gland tumors was 40 cases for male and 56 case for female (male/female ratio was 1 : 1.4). 4. Mean age of patients with salivary gland tumor was 36.9 yeats and mean age for benign pleomorphic adenoma was 36.3 years. Mean age of carcinoma patients was 44.5 years. 5. Mean size of the salivary gland tumors was about 4.9㎝ in long diameter. Average size of benign tumor was 4.2㎝ and average size of carcinoma was 5.6㎝. 6. Mean value of time interval between onset of symptoms and diagnosis was 5.1 years. For benign tumor it was 5.2 years and carcinoma was about 4.8years.

卵巢의 原發性 惡性 絨毛上皮腫 : 症例 報告

姜大榮,李泰淑 충남대학교 의과대학 지역사회의학연구소 1975 충남의대잡지 Vol.2 No.2

A case of primary choriocarcinoma of the ovary in a 18-year-old virgin is reported. This tumor was very rare in the references. The diagnosis was not made preoperatively, and the evidence of precocious sexual signs was not stated. The prognosis is poor as illustrated in the cases reported (Table 1), death occurring in all cases in less than a years, and this case was expired 23 days after first excisional operation of the left ovarian tumor with possible metastasis to the brain.

酸 및 알카리 溶液의 氣管內 注入에 依한 肺水鐘發生과 Sodium Thiosulfate의 效果에 關한 實驗的 硏究

姜大榮 부산의대 1971 부산의대잡지 - 부산대학교 의과대학 Vol.11 No.2

해적판 서적의 제작ㆍ유통과정 추적

강대영 세계평화교수협의회 1987 廣場 Vol.173 No.-

목에 發生한 放線菌症 : 1例 報告 a Case Report

姜大榮,李泰淑 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.1

Actinomycosis is a progressive, suppurative or granulomatous fungal disease, with local or systemic manifestations, and is thought to be common disease, but is relatively rare in literatures. Recently we have experienced a case of actinomycosis in the neck. A brief review of literatures and a discussion concerning actinomycosis are presented in this paper.

Effects of host modulation by nonsteroidal anti-inflammatory drugs on periodontal disease: a systematic review and meta-analysis

강대영,조인우,신현승,안형식,김현정,박정철 대한턱관절교합학회 2017 구강회복응용과학지 Vol.33 No.1

Purpose: Nonsteroidal anti-inflammatory drugs that prohibit biosynthesis of arachidonic acid metabolites have been considered potent host modulation agents. The aim of this review was to determine the effect of nonsteroidal anti-inflammatory drugs adjunctive with nonsurgical periodontal treatment in patients with periodontal disease. Materials and Methods: Three electronic databases were searched to identify relevant studies. The methodological quality and mean differences of the change in clinical attachment level and probing depth were analyzed according to Cochrane review methods. Results: Twelve studies were included in the methodological assessment and nine studies were suitable for inclusion in the meta-analysis. The mean difference in the clinical attachment level gain did not differ significantly between the nonsteroidal anti-inflammatory drugs and control groups at any observation time. The highest mean difference in clinical attachment level gain was 0.30 mm at 4 weeks (95% confidence interval = -0.37 to 0.97). There was a significant mean difference in the probing depth reduction, of 0.34 mm (95% confidence interval =0.29 to 0.40) at 6 weeks. Conclusion: Therefore, nonsteroidal anti-inflammatory drugs have additional therapeutic effect when administrated with nonsurgical periodontal treatment.

兩側 卵巢에 轉移한 충垂의 原發性 腺癌 : 症例 報告

姜大榮,金源式 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.2

Priniary adenocarcinomas of the appendix are very rare neoplasms in the references. The first instance of a primary adenocarcinoma of the appendix was reported by Berger in 1882. Since that report, about 200 additional cases have appeared in the world literatures and in the domestic area. Recently, we experienced a case of adenocarcinoma arising from the appendix with metastasis to both ovaries in a 31 years old female, who complained abdominal pain, abdominal adistension, and palpable masses. A brief review of literatures pertinent to this case was done.

사염화탄소 중독이 신장에 미치는 영향에 대한 연구

강대영 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

In an attempt to elucidate the nephrotoxic effects of carbon tetrachloride (CCl_4) administration, the present study was undertaken in male Sprague Dawlev rats. All animals were fasted for 16 to 18 hours prior to CCI_4, administration. Rats were administered 0.4ml/kg of carbon tetrachloride (CCl_4-olive oil 1 : 4 solution) intraperitoneally and were sacrificed at the 3rd, 6th, 12th, 24th, 36th, 48th and 96th hour after CCl_4 injection. The histopathological changes in the liver and kidney were noted as follows : 1. Light microscopically, the epithelial cells of the proximal convoluted tubules showed cellular swelling and vacuolation. They were prominent, especially at the 24th or 36th hour after CCl_4, administration. 2. Electron microscopically, the mitochondrial changes were characteristic, and then they revealed variations in shape, cristae fragmentation or loss, and segmental loss of membrane with myelin figure formation. 3. Electron microscopically. some mitochondria showed single membrane bound cyst formation with or without myelin figures at the 24th or 36th hour, but it was not noted at the 96th hour. 4. Light microscopically. the liver showed moderate to severe necrosis in the lobules at the 24th or 36th hour, but it was unremarkable at the 96th hour. In conclusion, the results obtained the present study indicate carbon tetrachloride induced moderate to severe hepatic necrosis and subtle lesions of the kidney at the level of light microscopy. This asynchrony suggests that the tubular lesions were related to CCl_4, but it does not exclude the possibility that the toxic substance was a metabolite of CCl_4 which could have been produced in the liver.

만성 B형 간염 환자의 간 생검 소견과 HBsAg 및 HBcAg 발현 양상 관계

강대영,최정목 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To elucidate the significance of HBsAg and HBcAg expression patterns in the liver, 36 cases of chronic hepatitis(19 CAH, 16CPH) were studied by immunohistochemical method and clinical laboratory data such as GOT and GPT. The results were as follows ; 1. With immunohistochemical staining, HBcAg was expressed in the 25 out of 36 cases(69.4%), and HBsAg was expressed in the total cases(100.0%) 2. The incidence of cytoplasmic HBcAg expression in chronic active hepatitis(15 cases; 78.9%) was similar to that. of nuclear HBcAg(12 cases, 63.2%), whereas that of chronic perisistent hepatitis was higher in the nucleus(58.9%) than in the cytoplasm (29.4%). 3. With tissue expression pattern of HBcAg and HBsAg according to pathological diagnosis, the pattern IV was predominant in the chronic active hepatitis (63.2%), whereas the pattern II(47.1%) and III(35.3%) were predominant in the chronic perisistent hepatitis. 4. The high serum transaminase levels was coincided with the decreasing nuclear HBcAg expression and with the increasing cytoplasmic HBcAg expression. The results suggest that expression of HBcAg correlates with prognosis of chronic hepatitis B virus infection.