스펙트럼영역 빛간섭단층촬영기를 이용한 정상인의 황반부 측정치와 측정의 반복성 및 재현성

강나희,김현진,이정희,Na Hee Kang,MD,Hyun-jin Kim,MD,Jeong-hee Lee,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.10

Purpose: We investigated reproducibility and repeatability of average macular thickness and volume measurements in normal eyes with Cirrus HD OCT (optical coherence tomography). Methods: Fifty normal eyes from twenty-five subjects without medical and ocular histories were included. Macular cube 512 × 128 combination scanning using the Cirrus HD OCT was performed for a total of three times on the same visit by an experienced technician. Then other two technicians performed one more macular scanning respectively. Within-results, the intraclass correlation coefficient (ICC) was calculated for each parameter studied to evaluate repeatability and reproducibility. The correlation between macular measurements and demographic variables (age, gender, and spherical equivalent) were also investigated. Results: The ICCs for intraoperator reproducibility were 0.99 on the average macular thickness and 0.96 on the macular volume. And the ICCs for interoperator repeatability were found to be 0.98 and 0.96, respectively. The ICCs for measurements of nine regional retinal thickness also were higher than 0.90. The retinal thickness was correlated with age, gender and refractive error. However, neither age nor refractive error affected to reproducibility and repeatability. Conclusions: The retinal thickness and macular volume measurements using Cirrus HD OCT in healthy volunteers showed excellent reproducibility and repeatability. Therefore, Cirrus HD OCT has been recognized as an useful tool for diagnosis and mornitoring of variable maculopathies. J Korean Ophthalmol Soc 2011;52(10):1182-1188

샤임플러그 전안부사진기를 이용한 눈물막의 두께 측정 및 건성안 지표와의 관계 분석

강나희(Na Hee Kang)박연꽃(Yeon Ggoch Park),전루민(Roo Min Jun) 대한안과학회 2015 대한안과학회지 Vol.56 No.11

목적: 정상안과 건성안 두 군에서 Pentacam Ⓡ (Oculus, Wetzlar, Germany)을 이용하여 측정한 각막 앞 눈물막 두께(precorneal tear film thickness, PTFT)를 포함한 전안부 계측값을 비교해 보고, 건성안 군에서 PTFT와 건성안 지표들과의 관련성을 알아보고자 하였다. 대상과 방법: 정상안 31안(23명), 건성안 31안(25명)을 대상으로 Pentacam Ⓡ을 이용하여 측정한 PTFT, 각막두께 및 난시 값을 비교하 였다. 건성안 군에서 PTFT와 플루오레신 눈물막 파괴 시간(fluorescein tear break-up time, FBUT), 쉬르머 I 검사 및 안구표면질환지 수(ocular surface disease index, OSDI)와의 관련성을 알아보았다. 결과: 평균 PTFT는 정상안에서 37.6 ± 2.0 μm, 건성안에서 21.1 ± 2.0 μm로 건성안 군의 PTFT가 정상안에 비해 유의하게 얇았다 ( p <0.01). 건성안 군에서 각막두께는 더 두꺼웠으나 임상적으로 의미 있는 차이는 없었고, 각막난시의 빈도 및 정도가 높은 경향을 보였지만 통계적으로 유의하지 않았다. 건성안 군에서 OSDI는 FBUT 및 쉬르머 I 검사와 약한 음의 상관관계를 보였으나 유의하지 않았고, PTFT와는 통계적으로 유의한 음의 상관관계를 보였다(r=-0.46, p <0.01). PTFT는 FBUT와 쉬르머 I 검사와 약한 양의 상관관 계를 보였으나 통계적으로 유의하지 않았다. 결론: 건성안에서 Pentacam Ⓡ 으로 측정한 PTFT는 정상군에 비해 유의하게 얇았으며 주관적인 증상과 연관성을 보여 건성안 환자의 진단 및 치료에 유용하게 활용될 수 있을 것으로 생각된다. Purpose: To compare the anterior segment parameters including precorneal tear film thickness (PTFT) using Pentacam ??(Oculus, Wetzlar, Germany) between normal control and dry eye groups and to examine the relationships between the PTFT and other parameters for dry eye. Methods: The present study included 23 normal controls (31 eyes) and 25 patients with dry eyes (31 eyes). We compared meas-urements including PTFT, corneal thickness and astigmatism using Pentacam ?? and analyzed the correlations among the PTFT and fluorescein tear break-up time (FBUT), Schirmer I test (without anesthesia), and ocular surface disease index (OSDI). Results: The mean PTFT in dry eyes (21.1 ± 2.0 μm) was significantly thinner than in normal eyes (37.6 ± 2.0 μm; p < 0.01). In the dry eye group, the corneal thickness was thicker than in the normal eye group but there were no clinically significant differences. The dry eye group experienced more frequent and severe corneal astigmatism compared with the normal group. OSDI scores showed a weak negative correlation with objective clinical measures of dry eye (FBUT, Schirmer I test) but was not statistically significant. However, OSDI was statistically significantly negatively correlated with PTFT (r = -0.46, p < 0.01). The PTFT showed a weak positive correlation with FBUT and Schirmer I test without statistical significance. Conclusions: The mean PTFT using Pentacam ?? in the dry eye group was thinner than in the normal group. Additionally, the PTFT was correlated with subjective symptoms. Therefore, the PTFT measurement using Pentacam ?? could be considered a useful method for diagnosis and treatment of dry eye.

수학적 모델을 이용한 반사율 기반 혼합염료의 흡광도 그래프에 관한 연구

강나희(Na-Hee Kang),김세영(Se-Young Kim),황지용(Ji-Yong Hwang),오현우(Hyun-woo Oh) 대한전자공학회 2023 전자공학회논문지 Vol.60 No.6

건성안 지표와 서로 다른 두 기기로 측정된 전면 각막 고위수차의 관계 분석

조아란,강나희,전루민.Ah Ran Cho. MD. Na Hee Kang. MD. Roo Min Jun. MD. PhD 대한안과학회 2015 대한안과학회지 Vol.56 No.1

Purpose: To compare the corneal first surface higher-order aberrations (HOAs) of normal subjects and patients with dry eye using KR-1W<SUP>Ⓡ (Topcon Corp., Tokyo, Japan) and Pentacam<SUP>Ⓡ HR (Oculus Inc., Dutenhofen, Germany). We analyzed the relationship between the aberrations and the diagnostic parameters of dry eye. Methods: We evaluated anterior corneal HOAs in 71 normal eyes and 71 dry eyes using KR-1W<SUP>Ⓡ and Pentacam<SUP>Ⓡ. Dry eye patients were examined for fluorescein staining, tear break-up time (TBUT), and Schirmer I test. Ocular Surface Disease Index (OSDI) was used for assessment of subjective symptoms in dry eye patients. Results: HOAs measured by both instruments were greater in the dry eye group than in the control group, although HOAs using KR-1W<SUP>Ⓡ only achieved statistical significance. The anterior corneal HOAs measured by the 2 instruments were significantly correlated with superficial punctate keratitis. Moreover, TBUT and the Shirmer I test negatively correlated, and OSDI positively correlated, with anterior corneal HOAs. Conclusions: The HOAs in patients with dry eye were significantly different from controls and tended to increase with disease severity. KR-1W<SUP>Ⓡ might be more useful than Pentacam<SUP>Ⓡ to detect tear film instabilities. J Korean Ophthalmol Soc 2015;56(1):6-12

염료 배합 비율 AI 추천 시스템에 관한 연구

김세영(Se-Young Kim),강나희(Na-Hee Kang),황지용(Ji-Yong Hwang),오현우(Hyun-Woo Oh) 대한전자공학회 2023 전자공학회논문지 Vol.60 No.6

두 샤임플러그 방식의 수차측정기기로 측정한 각막 고위수차 비교

최연정(Yeon Jung Choi, MD),강나희(Na Hee Kang, MD, PhD),전루민(Roo Min Jun, MD, PhD) 대한안과학회 2015 대한안과학회지 Vol.56 No.10

목적: 정상안에서 GalileiTM G4 (Zeimer, Port, Switzerland) 와 Pentacam?? (Oculus Inc., Wetzlar, Germany)으로 측정한 각막 고위수차를 비교해 보고자 한다. 대상과 방법: 정상안 41안을 대상으로 한 명의 검사자가 GalileiTM G4와 Pentacam?瑛막? 각각 3회씩 반복하여 각막 고위수차를 측정하였다. 두 수차측정기의 검사자 내 반복성을 급내상관계수(Intraclass correlation coefficient, ICC)로 평가하였으며, 두 기기로 측정된 각막 고위수차 계측치를 비교하고 상관성을 알아보았다. 결과: 정상안에서 GalileiTM G4와 Pentacam?瑛막? 측정한 각막 고위수차의 ICC는 세조각수차, 네조각수차 및 4차, 5차 총 고위수차를 제외한 모든 계측값에서 ICC가 0.81 이상으로 중등도 이상의 반복성을 보였다. 두 기기로 측정한 각막 고위수차의 root mean square (RMS) 값을 비교하였을 때, 총 각막수차(p<0.001), 구면수차(p=0.001) 및 5차 총 고위수차값(p<0.001)에서 두 기기 간에 유의한 차이를 보였다. 또한 기기 간 계측치의 일치도를 평가하였을 때 모든 고위수차 항목에서 두 기기 간에 낮은 일치도를 보였다. 총 각막수차와 구면수차는 두 기기 계측치 간에 통계적으로 유의한 상관관계를 나타내었으나, 그 외의 고위수차 계측값에서는 전반적으로 낮은 상관관계를 나타냈다. 결론: 동일한 원리의 두 기기는 각막 고위수차 측정에서 비교적 높은 재현성을 보이지만, 각막 고위수차 계측치에서 차이를 보이고 두 기기 간 낮은 일치도를 나타내므로 임상에서 상호 호환하여 사용하기에는 제한점이 있을 것으로 사료된다. Purpose: To compare the corneal higher-order aberrations (HOAs) of normal young subjects using GalileiTM G4 (Zeimer, Port, Switzerland) and Pentacam?? (Oculus Inc., Wetzlar, Germany). Methods: Corneal HOAs were measured using GalileiTM G4 and Pentacam?? in 41 healthy individuals (41 eyes). Intraclass correlation coefficients (ICCs) were obtained to evaluate the repeatability of the 2 devices. Differences in HOAs between the 2 instruments were analyzed with a paired t-test and correlations evaluated. Results: All ICCs measured using GalileiTM G4 and Pentacam?? showed more than moderate repeatability (>0.81) except trefoil, tetrafoil, 4th and 5th HOAs. When comparing the measurements obtained with GalileiTM G4 and Pentacam??, total HOAs, spherical aberration (SA), secondary astigmatism and 5th total HOAs were statistically significantly different between the 2 device (all p ≤ 0.001). In addition, GalileiTM G4 and Pentacam?? showed discrepancy among all corneal HOAs items. Although the total corneal HOAs and the SA were significantly correlated, other HOA measurements generally exhibited a low correlation. Conclusions: Corneal HOAs obtained by the 2 instruments cannot be used interchangeably due to their differences and discrepancy although corneal HOAs measured using GalileiTM G4 and Pentacam?? showed relatively high repeatability.