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Enhanced Bioavailability of Paclitaxel by Bamboo Concentrate Administration
강건욱,최준식 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.4
The purpose of this study was to investigate the effect of a cotreatment of bamboo concentrates (Jukcho solution; 0.75, 1.5, and 3.0 mL/kg) with the chemotherapeutic agent paclitaxel on the bioavailability of orally administered paclitaxel (50 mg/kg) in rats. The effect of a pretreatment of bamboo concentrates (1.5 and 3.0 mL/kg for 1.0 h or a consecutive 3 day) was also examined. The paclitaxel plasma concentrations of rats orally administered paclitaxel plus bamboo concentrates (coadministration, 3.0 mL/kg and pretreatment, 1.5 and 3.0 mL/kg) were significantly higher than those of rats treated with paclitaxel alone. Plasma concentrations of paclitaxel in groups pretreated with bamboo concentrates for 3 day were markedly higher than those of a paclitaxel control group at the measured time points. The areas under plasma concentration- time curves (AUCs) of paclitaxel in groups pretreated with bamboo concentrates were elevated and the absolute bioavailability (AB%) and relative bioavailability (RB%) of paclitaxel were also significantly higher than those in the control group. The peak concentration (Cmax), half-life (t1/2), and the elimination rate constant (Kel) of paclitaxel after 3 day of pretreatment with bamboo concentrates were also significantly higher than those in the control, but the time required to reach the maximum plasma concentration (Tmax) of paclitaxel was unaffected by the bamboo concentrates. Western blot analyses demonstrated that the level of CYP3A4 was increased in the livers of rats treated orally with paclitaxel, but this was reversed by pretreating with bamboo concentrates. These results show that bamboo concentrates enhance the bioavailability of orally administered paclitaxel and this effect may be associated with a diminished expression of CYP3A4 in the liver.
강건욱 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.6
PACS (Picture Archiving and Communication System) is being rapidly spread and installed in many hospitals, but most of the system do not include nuclear medicine field. Although additional costs of hardware for nuclear medicine PACS is low, the complexity in developing viewing software and little market have made the nuclear medicine PACS not popular. Most PACS utilize DICOM 3.0 as standard format, but standard format in nuclear medicine has been Interfile. Interfile should be converted into DICOM format if nuclear images are to be stored and visualized in most PACS. Nowadays, many vendors supply the DICOM option in gamma camera and PET. Several hospitals in Korea have already installed nuclear PACS with DICOM, but only the screen captured images are supplied. Software for visualizing pseudo-color with color lookup tables and expressing with volume view should be developed to fulfill the demand of referring physicians and nuclear medicine physicians. PACS is going to integrate not only radiologic images but also endoscopic and pathologic images. Web and PC based PACS is now a trend and is much compatible with nuclear medicine PACS. Most important barrier for nuclear medicine PACS that we encounter is not a technical problem, but indifference of investor such as administrator of hospital or PACS. Now it is time to support and invest for the development of nuclear medicine PACS.
강건욱,김철성,고경신,고흥선,김삼진,박성호,박승일,신창언,심일운,이준영 한국물리학회 2006 새물리 Vol.52 No.4
Among the various social problems in Korea, students sociality of science and engineering majors has become one of the most urgent problems to be solved. So far a number of studies have been performed from the view point of society, government, and education, but there has been little study to solve the crisis of science and engineering from the view point of education. In this research, we studied about the causes of and the proper solutions to the problems in the curricula of Science and of Engineering in the university. To find the problems with scientific and engineering education, we performed the survey of the mathematics and science curricula at several universities. From an analysis of survey data provided by researchers in mathematics, physics, chemistry, and biology, we found problems in the subjects and curricula in the four basic scientific fields, compared with the cases of foreign universities in the USA, Japan, Taiwan, Europe, etc. 이공계 기피현상으로 시작된 이공계 위기 관련한 여러 가지 문제들이 현재 사회 문제로 대두되고 있다. 이러한 이공계 문제를 해소하기 위한 다양한 연구가 사회적인 측면, 경제적인 측면, 교육적인 측면에서 이루어지고 있지만, 정작 본질적인 분야인 교육적 측면에서 이공계 문제를 해결하기 위한 방안은 미미하다. 따라서 이공계 문제를 해결하기 위한 교육 분야에서 이공계 대학의 기초과학 과목에 대한 교육 및 교과운용방법의 문제점과 그에 대한 개선방안에 대하여 연구하였다. 국내외 대학의 이공계 기초 과학 분야에 대한 국내외의 설문 조사 및 실태조사가 실시되었고, 각 분야별 전문가 그룹에 의하여 현재 국내 대학에서의 기초 과학 교과목에 대한 문제점과 교육과정의 활용상의 문제점을 파악했으며 연구결과의 분석을 통하여 연구결과의 활용방안을 여러 부문에서 효과적으로 운용할 수 있는 토대를 마련하였다.
경도의 안구건조증 환자에서 굴절교정수술 전후 0.05% 사이클로스포린 사용의 효과
강건욱,김홍균,Kun Wook Kang,Hong Kyun Kim 대한안과학회 2014 대한안과학회지 Vol.55 No.12
Purpose: To evaluate the efficacy of pre- and post-operative use of topical 0.05% cyclosporine A (CsA) in mild dry eye patients having refractive surgery. Methods: This randomized prospective study included 40 patients with mild dry eye syndrome who were scheduled for laser in situ keratomileusis (LASIK). All patients were divided into 2 groups. Patients in the CsA group used both 0.1% sodium hyaluronate (HA) and 0.05% CsA from 2 weeks before to 8 weeks after the surgery, while patients in the control group used 0.1% HA only. Ocular surface disease index (OSDI), tear film break-up time (TF-BUT), Oxford Stain Score (OSS), and tear osmolarity were evaluated before surgery and 1, 4, and 8 weeks after surgery. Results: TF-BUT was significantly longer in the CsA group at 1 and 4 weeks post-operatively (<EM>p </EM>= 0.024, <EM>p </EM>= 0.036) compared to the control group. Tear osmolarity was significantly lower in the CsA group at 1 week post-operatively (<EM>p </EM>= 0.004) compared to the control group. Conclusions: The pre- and post-operative use of topical 0.05% CsA is effective in alleviating dry eye symptom after LASIK in patients with dry eye syndrome. J Korean Ophthalmol Soc 2014;55(12):1752-1757