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Antiapoptotic Fusion Protein Delivery Systems
김용희,Cheau Yih Tan 한국고분자학회 2008 Macromolecular Research Vol.16 No.6
Apoptosis is a natural cell suicide mechanism to maintain homeostasis. However, many of the diseases encountered today are caused by aberrant apoptosis where excessive apoptosis leads to neurodegenerative disorders, ischemic heart disease, autoimmune disorders, infectious diseases, etc. A variety of antiapoptotic agents have been reported to interfere with the apoptosis pathway. These agents can be potential drug candidates for the treatment or prevention of diseases caused by dysregulated apoptosis. Obviously, world-wide pharmaceutical and biotechnology companies are gearing up to develop antiapoptotic drugs with some products being commercially available. Polymeric drug delivery systems are essential to their success. Recent R&D efforts have focused on the chemical or bioconjugation of antiapoptotic proteins with the protein transduction domain (PTD) for higher cellular uptake with antibodies for specific targeting as well as with polymers to enhance the protein stability and prolonged effect with success observed both in vivo and in vitro. All these different fusion antiapoptotic proteins provide promising results for the treatment of dysregulated apoptosis diseases.
김용희 한국음악교육학회 2020 음악교육연구 Vol.49 No.4
The purpose of this study is to examine the contents of sociology of music education of Regelski and to suggest implications for Korean music education. To this end, his views on music and music education based on his praxis theory, criticism on traditional music education, and his suggestions regarding music curriculum were examined. The implications of Regelski’s perspectives for Korean music education are the following: The consideration of the practical results of music education, the active use of technologies, the balance in music education repertoire, and the dialogues and communications between experts in designing a national music curriculum.
김용희 한국음악교육학회 2011 음악교육연구 Vol.40 No.3
This study investigated the perceived environments and perception differences between subgroups of 202 musically talented students enrolled in 12 public institutes for the musically gifted and talented in Korea. The subgroups are divided based on the variables of major instruments, initial age of music education, initial age of professional training, and practice time per day. It was found that the students showed positive perception about the economical and emotional support from their families and musical and emotional help from their teachers. However, they did not have positive perception about direct musical help from their families and social chances such as music camp and master classes. The ANOVA analysis of the subgroups suggested that the variables of age, major instrument, the initial age of music education, the initial age of professional training and practice time had influences on their environmental perceptions. Findings of this study also have implication that the social chances for the musically talented need to be expanded.