[인터뷰] 한국과학기술연구원 뇌과학연구소 김진현 소장

김진현,김아영,양회관 대한기계학회 2022 기계저널 Vol.62 No.10

한방의료의 건강보험 적정 본인부담률 추계

김진현,유왕근,서동민 한국보건행정학회 2007 보건행정학회지 Vol.17 No.1

This study is designed to estimate an appropriate level of patient's cost-sharing for oriental medical services in the Korean National Health Insurance. The findings of this study can be summarized as follows: 1) The current co-payment system for oriental medical services does not reflect its cost structure in clinical practice due to inconsistency of cost-sharing plan in the NHI. 2) Both oriental medical institutions and their patients, as a result, are at a relative disadvantage in financial burden, compared with other services. 3) The substantial proportion of patients' cost-sharing depends on the amount of co-payment and the range of medical cost that a flat rate is applied to. 4) The extension of the range doesn't make any substantial decrease in patient's cost-sharing. 5) The fixed amount of co-payment is more sensitive than a range to total variations of patient's cost-sharing. Based on the above, the budget impacts of a new co-payment system were estimated for each co-insurance rate, according to given scenarios. The results range from -59 billion Won(-8.5%) to 16 billion Won(2.3%).

서울시 1인 가구 주택점유 형태 연구

김진현 인문사회 21 2019 인문사회 21 Vol.10 No.3

The ratio of single-person household in South Korea rose to 28.6% in 2017. The percentage represents one of the fastest growth of single-person households among OECD countries. The goal of this study is to offer suggestions by specifying elements that may have effects on the type of housing tenure of single-person households in Seoul using one-to-one survey data with 390 respondents. Correlation analysis was conducted for Jeonse, Jeon-wolse (the combination of both Joense and a monthly rent), Wolse (monthly rent) without key deposit, on the basis of ‘owned’ as a standard analysis. Multinominal logistic regression was adopted as a statistical technique. The analysis results are as follow. When log likelihood rate test (LRT) was applied to verify significance of the model, independent variables have significant effects in explaining dependent variables. Cox and Snell values and Nagelkerke values that measure explanatory power of the model were also found to be appropriate for the change of response variables. As current research was focusing on Seoul only, it was inappropriate to generalize the findings and apply them to other cities nationwide. In addition, it failed to adopt various variables. Therefore, more multi-dimensional and systematic research is needed in the future so as to validate interaction effects by combining time series variables and housing tenure forms, and applying various analysis models. 우리나라 1인 가구 비중은 2017년도 기준 28.6%까지 증가하였다. 이는 OECD 국가 중에서도 가장 빠르게 증가하는 수치다. 본 연구는 서울시 1인 가구 390명에 대한 1대1 대면 설문 데이터로 1인 가구의 주택점유 형태에 영향을 미치는 요인들을 규명하여 이에 대한 시사점을 제시하는 데 목적이 있다. 분석 시 기준범주는 ‘자가’를 기준으로 전세, 전・월세, 보증금 없는 월세에 대한 영향 관계를 분석하였다. 분석기법은 다항로지스틱 회귀모형을 활용하였다. 분석결과는 다음과 같다. 모형의 유의성 검정을 위한 우도비 검정통계량(LRT: Log Likelihood Rate Test)을 검정한 결과 독립변수가 종속변수를 설명하는 데 중요한 영향력이 있는 것으로 밝혀졌다. 또한 모형의 설명력을 평가하는 Cox and Snell 값과 Nagelkerke 값도 반응변수의 변동 정도에 적합한 것으로 나타났다. 향후 연구과제로는 전국이 아닌 서울시에 한정함으로써 일반화하는 데는 한계점이 있다. 또한 다양한 변수를 채택하지 못했다는 한계점도 있다. 분석모형도 다양화하여 시계열적인 변수들을 주택점유 형태와 결합하여 상호작용 효과(interaction effects) 등을 검증하는 다차원적이고 체계적인 후속연구들이 필요할 것이다.

Purification of homoharringtonine and removal of residual solvents by spray drying

김진현,Byung-Sik Kim 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.1

Homohamingtonine was purified from Cephalotaxus koreanaadsorbent treatment, low-pressure chromatography, and high performance liquid chromatography (HPLC). A crudeextract was obtained by methanol extraction of biomass, followed by liquid-liquid extraction using chloroform. Thewaxy compounds were efficiently removed by adsorbent (active clay P-1) treatment. The extract was purified to greaterthan 52% with an 86.4% step yield by silica gel low-pressure chromatography. High performance liquid chromatog-raphy steps, which were composed of an HPLC step with silica column and an HPLC step with ODS column, wereapplied to give 98% purity with high yield. Amorphousby dissolving homoharringtonine in methylene chloride/methanol (98/2, v/v), followed by spray drying. Residual sol-vents, methylene chloride and methanol, could be reduced to 250 ppm and 1,160 ppm by spray drying and successivedrying in a vacuum oven.

A Clinical Trial and Extension Study of Infliximab in Korean Patients with Active Rheumatoid Arthritis despite Methotrexate Treatment

김진현,류희정,유대현,박성환,송관규,박원,조철수,송영욱 대한의학회 2013 Journal of Korean medical science Vol.28 No.12

Currently, infliximab is given for disease control for active rheumatoid arthritis (RA) patients despite methotrexate treatment. However, the efficacy and safety of infliximab in Korean patients has not been assessed appropriately. Therefore, we performed placebo-controlled, double-blind, randomized study and extension study. One-hundred forty-three patients with active RA were randomized to receive placebo or infliximab 3 mg/kg intravenously at week 0, 2, 6, 14, and 22 with methotrexate maintenance. Primary endpoint was American College of Rheumatology 20% improvement criteria (ACR20) at 30 week. After the clinical trial, patients on placebo (Group 1) and patients on infliximab who showed ACR20 response (Group 2) were treated with infliximab through another 84 week for evaluation of safety. During clinical trial, patients in infliximab group showed higher ACR20 at week 30 than patients in placebo group (50.1% vs 30.6%, P=0.014). A total of 92 patients participated in the extension study. The maintenance rate of infliximab was 62.0% at 84 weeks of extension study. The overall rate of adverse events was not different between Group 1 and Group 2. In Korean patients with active RA despite methotrexate treatment, infliximab in combination with methotrexate is effective and the long-term treatment with infliximab is well tolerated. (ClinicalTrials.gov No. NCT00202852, NCT00732875)

음악, 제스처, 인터액션 컴퓨터 시스템을 매개로 한 동작과 사운드의 인터액션에서 표현성에 대한 연구

김진현 한국전자음악협회 2004 에밀레 Vol.- No.3

Optimization of Micellar Extraction for the Pre-purification of Paclitaxel from Taxus chinensis

김진현,Keum-Young Jeon 한국생물공학회 2007 Biotechnology and Bioprocess Engineering Vol.12 No.4

Currently, there are many reports in the literature regarding technological methods for paclitaxel purification. However, there have been few reports on the purification of paclitaxel using a micellar system. This method is based on the transfer of paclitaxel within the crude extract to an aqueous surfactant solution as a micelle, allowing the use of organic solvents to be used for the removal of lipids and non-polar impurities. In this study, we optimized the important process parameters of micellar extraction to obtain a high purity and yield of paclitaxel in a pre-purification step. The optimal surfactant (N-cetylpyridinium chloride, CPC) concentration, initial crude paclitaxel concentration, organic solvents (methyl t-butyl ether/hexane) ratio, extraction temperature, and extraction time were 7.5% (w/v), 16.4 mg/mL, 1.5/1 (v/v), 25℃, and 30 min, respectively. The crude extracts from the liquid-liquid extracts were efficiently pre-purified by micellar extraction, increasing in purity from 6% to over 21%, with a yield of 92%. Overall, the use of micellar extraction in the pre-purification process allowed for rapid and efficient separation of paclitaxel from interfering compounds, and dramatically increased the yield and purity of the crude paclitaxel for subsequent purification steps.

大慧禪에 溶解된 華嚴思想에 對한 小考

김진현 한국불교학회 2006 韓國佛敎學 Vol.46 No.-

Affective computing에 기반한 시스템 EyesWeb

김진현 한국전자음악협회 2001 에밀레 Vol.- No.1

언론인이라는 것

김진현 관훈클럽 2006 관훈저널 Vol.- No.100